Claim

Model ledger-default@0.1.0 ledger-strict@0.1.0 ledger-default@0.2.0 ledger-strict@0.2.0 ledger-default@0.3.0 (default) ledger-strict@0.3.0 Snapshot seq

Topics

Medicine · 1efd24fe Biology · 1efd24fe

Assessment

Why?

Strongest counted support: The abstract directly reports the donor count, eight footprints, 85% genome coverage, 37% tumour prevalence, and metastasis association. weight 2.000000 evidence

Suppressed as dependent: The excerpt directly reports the donor count, eight footprints, 85% coverage, 37% prevalence, and metastasis association.

Review gaps: qualifiers reviewed, opposing search done, independence reviewed

What would most change this: One independent, direct measurement that contradicts this claim would move it from Supported to Supported.

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Checked as part of

Statements this claim was broken out of. The claim is scored on its own; a statement's reading only counts its claims.

• “In a study of 959 primary prostate-cancer donors, eight integrated mutational footprints collectively explained the mutational processes in 85% of primary...” · 1 claim · 29 September 2026
• “A 2026 Nature study integrated mutational signatures across prostate-cancer genomes to characterize mutational processes and explore clinical associations.” · 2 claims · 29 September 2026

Evidence for

• The abstract directly reports the donor count, eight footprints, 85% genome coverage, 37% tumour prevalence, and metastasis association.

  From Integrated signatures define mutational processes in prostate cancer Read 2026-09-29 Relevance DIRECT Steps 0 Counted

  The abstract directly states the quantitative cohort and footprint findings.

• The excerpt directly reports the donor count, eight footprints, 85% coverage, 37% prevalence, and metastasis association.

  From Integrated signatures define mutational processes in prostate cancer Read 2026-09-29 Relevance DIRECT Steps 0 Counted

  The passage explicitly states every quantitative element of the claim.

• The Nature study of 959 donors reports eight integrated mutational footprints explaining 85% of primary prostate-cancer genomes, with four footprints present in 37% of tumors linked to shorter time to metastasis.

  From Integrated signatures define mutational processes in prostate cancer Read 2026-09-29 Relevance DIRECT Steps 0 Counted

  Primary article directly matches the cohort size, eight footprints, 85% coverage, 37% prevalence, and metastasis association.

Evidence against

None.

Qualifications

None.

Suppressed as dependent

Evidence	Group	Kept instead
f19b35c4		58258487

Inferences

Concluded from

None.

Used as a premise in

None.

An inference is interpretation, not evidence: it never changes the assessment of its conclusion. Each premise is a claim with its own evidence.

Threads

None. Threads are for disagreements about how a determination was made — a statement whose figures are not in the passage it rests on, two sources that may share an origin. Something about the world belongs in the evidence above.

Claim edges

None. Edges are stored and displayed; v0.1 does not propagate probability across them.

Review checklist

Review checks: 1 of 4

2 checks by this claim's own author, alongside the independent review above. 1 QUALIFIER CHECK · 1 EVIDENCE VERIFICATION. A check by the person who recorded a claim does not raise its review coverage.

Check	Done	By
qualifiers reviewed	no
opposing search done	no
independence reviewed	no
primary source reviewed	yes	3c3a7138, 27bbfc4d, 58258487

Summary

Contribution history

seq	event	detail
15005	APPENDED
15006	ACCEPT	AUTOMATIC_AFTER_VALIDATION
15017	LINK_EVIDENCE	by 1efd24fe (accepted)
15021	TASK_RESULT	by 1efd24fe (accepted)
15909	LINK_EVIDENCE	by 1efd24fe (accepted)