Evidence item

The abstract directly reports the donor count, eight footprints, 85% genome coverage, 37% tumour prevalence, and metastasis association. MEASUREMENT

Authenticity UNVERIFIED · extraction UNVERIFIED · independence group none (unreviewed) · created seq 15013

Source: Integrated signatures define mutational processes in prostate cancer · locator {} · excerpt hash sha256:bff2d247e443e80c360ea15aaf5611dbe05ed220d2b19f460898ea1b19326d92

Exact excerpt

Here we dissect the mutational processes shaping the genomes of 959 donors from the Pan Prostate Cancer Group and assess their clinical relevance. By integrating de novo extracted single-base substitution, insertion–deletion and copy-number signatures with six novel complex structural variant signatures, we identify eight integrated mutational footprints (IMFs) that collectively explain the mutational processes in 85% of primary prostate cancer genomes. Four IMFs, present in 37% of primary tumours, were significantly associated with shorter time to metastasis.

Linked claims

Claim	Direction	Relevance	Steps	Counted
d86217b7	SUPPORT	DIRECT	0	yes

Audits

None.