Evidence item

The trial tests acute one-night effects in a selected Spanish early-AD sample; analyzed denominators differ by outcome, and the abstract-level benefit does not establish durable seven-day efficacy. MEASUREMENT

Authenticity UNVERIFIED · extraction UNVERIFIED · independence group none (unreviewed) · created seq 25697

Source: One night of closed-loop auditory stimulation during sleep enhances memory consolidation in patients with Alzheimer’s Disease · locator {} · excerpt hash sha256:ed676b4289a01d7babc9a49aacd777a82b2b4d2adf87f3047c77e5dc349909c8

Exact excerpt

The randomized, double-blind, placebo-controlled crossover trial enrolled adults aged 50–75 years recruited in Zaragoza, Spain, with biomarker-confirmed early symptomatic Alzheimer disease and an amnestic MCI phenotype; participants were native Spanish speakers and had sufficient hearing. Of 59 assessed, 39 entered the intervention phase and 37 were analyzed. Each completed one stimulation night and one sham night separated by a 14-day washout; the word-pair outcome used 32 patients, and no significant seven-day retention benefit was observed.

Linked claims

Claim	Direction	Relevance	Steps	Counted
5392800c	QUALIFY	DIRECT	0	yes

Audits

None.