Evidence item

The age-related lymphatic loss was chamber-specific in mice, and restoring density reduced macrophages without establishing recovery of all cardiac functional outcomes. MEASUREMENT

Authenticity UNVERIFIED · extraction UNVERIFIED · independence group none (unreviewed) · created seq 25747

Source: Age-related decline in cardiac lymphatic vessel density is associated with cardiac edema and immune cell accumulation · locator {} · excerpt hash sha256:48e0b961e6365cd085e2b088ca852f687f067300ddaec5b4a63125c3b0d60ae8

In old mouse hearts, lymphatic vessel density declined in the left ventricle but not the right ventricle. AAV9-mediated Vegfc expression in aged mice increased cardiac lymphatic density and reduced macrophage density; the report’s conclusion was reduced inflammation, while the intervention did not establish restoration of all cardiac function.