Evidence item

The excerpt directly reports a randomized double-blind placebo-controlled crossover trial of 37 biomarker-confirmed early Alzheimer patients over one night versus sham. DIRECT_TEXT

Authenticity UNVERIFIED · extraction UNVERIFIED · independence group none (unreviewed) · created seq 24620

Source: One night of closed-loop auditory stimulation during sleep enhances memory consolidation in patients with Alzheimer’s Disease · locator {} · excerpt hash sha256:84314fd2a537f86a74c71973bab90e6fbc01be063c8f8b8c50e5b2c01e28c043

We conducted a randomized, double-blind, placebo-controlled crossover trial in 37 patients with biomarker-confirmed early symptomatic AD and an amnestic clinical phenotype. We assessed the effect of one night of CLAS, compared with one night of sham stimulation, on declarative memory retention, sleep electrophysiology, and sleep architecture.