Evidence item

A secondary scientific report corroborates the SRPX2–IRP1 interaction, disrupted iron regulation, and reduced UUO-induced fibrosis after therapeutic iron-dextran supplementation. DIRECT_TEXT

Authenticity UNVERIFIED · extraction UNVERIFIED · independence group none (unreviewed) · created seq 20502

Source: 苏州大学团队发现肾纤维化新轴：SRPX2劫持IRP1致铁失调 · locator {} · excerpt hash sha256:af3e25897e5623d43a56951eff55e534ede46135222bc7309905625ce92ac2c1

SRPX2与铁调控蛋白1（IRP1）...发生物理相互作用。这种相互作用破坏了IRP1/铁响应元件调控系统...最终触发细胞内铁稳态失调...治疗性右旋糖酐铁补充减轻了UUO诱导的肾纤维化。