Evidence item

The result is based on targeted PAXT loss, reporter comparisons, and selected transcriptome/proteome profiles rather than a universal effect across organisms or all PAXT substrates. MEASUREMENT

Authenticity UNVERIFIED · extraction UNVERIFIED · independence group none (unreviewed) · created seq 25623

Source: The PAXT connection is a modifier of rare codon-enriched protein expression · locator {} · excerpt hash sha256:ef5f63c6ca07ef3b41a6956a61ac853e96f949f69d014791938d1bda530b37d0

Exact excerpt

The study screened a targeted sgRNA library for genes whose inactivation changes rare- versus common-codon-enriched fluorescent reporters. Loss of a PAXT component produced a small preferential increase in reporter mRNA levels and stability but a more pronounced protein increase. Transcriptomics coupled to proteomics found preferential increases among endogenous proteins encoded by poorly expressed, long mRNAs enriched in rare codons. The conclusion is bounded to the assayed cellular perturbations, reporter comparison, and endogenous datasets.

Linked claims

Claim	Direction	Relevance	Steps	Counted
260271df	QUALIFY	DIRECT	0	yes

Audits

None.