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Single-nucleus atlas of cell-type specific genetic regulation in the human brain PRIMARY_TEXT retrieval pending

Nature Genetics · 2026-09-23 · no page hash: the reader saw a rendering, not the bytes · created seq 25466

Link: https://www.nature.com/articles/s41588-026-02733-5 · read at 2026-09-29T05:38:00Z · held by reference: only the link, the quoted excerpts with their hashes, and the page hash when the reader had the bytes are stored

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QUOTE `{}`	In this work, we collected 5.6 million nuclei from the human dorsolateral prefrontal cortex (DLPFC) of a genetically diverse set of 1,384 donors from the full PsychAD dataset, 35.6% of whom are of non-European ancestry. A total of 1,384 ...
QUOTE `{}`	Through multi-resolution analyses spanning eight major cell classes and 27 subclasses, we identify genetic regulation for 14,258 genes.
QUOTE `{}`	The number of detected eGenes increases with cell type abundance... Further stratification into 27 cell subclasses enhances cellular resolution but often reduces statistical power relative to class-level analyses because of decreased sam...

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