Galedra
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Broadly neutralizing antibodies in adult males living with HIV undergoing analytical treatment interruption: secondary and exploratory outcomes of the phase II randomized controlled RIO trial PRIMARY_TEXT retrieval pending
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| Locator | Excerpt |
|---|---|
QUOTE {} | Sixty-eight adult men living with human immunodeficiency virus (HIV), who were predominantly white and initiated antiretroviral therapy (ART) during primary or early-stage infection, underwent treatment interruption and were randomly ass... |
QUOTE {} | To determine how the bNAbs impact the size of the proviral reservoir in arm A, we compared the intact and defective proviral reservoirs at baseline with prerebound samples collected at a mean of 52 weeks after the initial infusion (n = 2... |
QUOTE {} | Therefore, these associations are correlative and based on a limited number of individuals, but the observed reservoir decay is suggestive of altered reservoir dynamics in this cohort of PLWH undergoing ATI under LS-bNAb exposure. |