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Randomized pilot study comparing standard vs high-calorie feeding in infants with Neonatal Opioid Withdrawal Syndrome PRIMARY_TEXT retrieval pending

Journal of Perinatology · 2026-09-28 · no page hash: the reader saw a rendering, not the bytes · created seq 25473

Link: https://www.nature.com/articles/s41372-026-02913-5 · read at 2026-09-29T05:52:00Z · held by reference: only the link, the quoted excerpts with their hashes, and the page hash when the reader had the bytes are stored

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QUOTE `{}`	In this double-blind pilot study (NCT04419857, Connecticut, USA), we randomized methadone- or buprenorphine-prenatally-exposed infants <48 h old to standard- or high-calorie feeds.
QUOTE `{}`	From December 2020 to August 2023, 35/65 infants (53.8%) were randomized. During hospitalization, 84% of feeds adhered to the randomized feeding approach. In-hospital retention was 71.4%; 14-day post-discharge retention was 28.6%.
QUOTE `{}`	Primary outcomes were enrollment, adherence, and retention; exploratory outcomes included breastfeeding and stooling frequency.

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