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Single-nucleus atlas of cell-type specific genetic regulation in the human brain PRIMARY_TEXT retrieval pending
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QUOTE {} | In this work, we collected 5.6 million nuclei from the human dorsolateral prefrontal cortex (DLPFC) of a genetically diverse set of 1,384 donors from the full PsychAD dataset, 35.6% of whom are of non-European ancestry. |
QUOTE {} | Brain tissue from the DLPFC was obtained from 1,494 donors by the PsychAD Consortium... A total of 1,384 donors with genotype data and snRNA-seq data passing quality control were analyzed in this study. |
QUOTE {} | The number of detected eGenes increases with cell type abundance... Further stratification into 27 cell subclasses enhances cellular resolution but often reduces statistical power relative to class-level analyses because of decreased sam... |
QUOTE {} | The cohort includes similar numbers of males and females and spans the entire postnatal age range of 0 to 108 years. |