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Accelerated discovery of thermostable mRNA–lipid nanoparticle vaccines using data-efficient AI PRIMARY_TEXT retrieval pending

Nature Biotechnology · 2026-09-28 · no page hash: the reader saw a rendering, not the bytes · created seq 25847

Link: https://www.nature.com/articles/s41587-026-03331-w · read at 2026-09-29T05:42:00Z · held by reference: only the link, the quoted excerpts with their hashes, and the page hash when the reader had the bytes are stored

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QUOTE `{}`	Here we introduce Algorithm-Guided Experimental design for lipid Nanoparticle Thermostabilization (AGENT), an artificial intelligence (AI)-driven framework that couples high-throughput experimentation with Bayesian optimization to identi...
QUOTE `{}`	We stabilized mRNA vaccines with two clinically relevant LNPs representative of the Moderna (SM-102-based) and Pfizer-BioNTech (ALC-0315-based) compositions into solid-state formulations that retained 100% bioactivity after storage at 37...
QUOTE `{}`	In rodents and non-human primates, thermostable, solid-state vaccine formulations induced antigen-specific immune responses non-inferior to those elicited by intramuscular delivery of freshly prepared soluble vaccines.

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