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Boston Children’s-led team develops prime assembly for large DNA insertions SECONDARY_TEXT retrieval pending

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Link: https://allsci.com/news/research/prime-assembly-boston-childrens-hospital-and/ · read at 2026-09-28T23:55:00Z · held by reference: only the link, the quoted excerpts with their hashes, and the page hash when the reader had the bytes are stored

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QUOTE `{}`	In primary CD3+ T cells from four healthy donors, prime assembly produced targeted integration at the TRAC locus, a site relevant to CAR-T cell engineering. In CD34+ hematopoietic stem and progenitor cells (HSPCs) from three healthy dono...
QUOTE `{}`	Beyond DNA insertion, the researchers used prime assembly to generate megabase-scale genomic rearrangements, including deletions, inversions, and interchromosomal alterations.