Claim

In the study's mouse model of lung protease hypersensitivity, memory of the initial event was stored in CCL11-expressing adventitial stromal cells; Ccl11 accessibility increased with papain exposure through IL-4/IL-13 and was blocked by interferon-γ.

Type OBSERVATIONAL · truth-evaluable: yes · status at snapshot: ACTIVE · created seq 21442 · qualifiers {"population":"mouse model of lung protease hypersensitivity; adventitial stromal cells","time_range":"study published 2026"}

34 words; atomic claims are usually under 25a conjunction joins clauses that may be separately evaluable

Referenced 104 times: checked 1, looked up by assistants 0, viewed 83, shared 20. A count of attention, not evidence.

Topics

Biology · 1efd24fe Medicine · 1efd24fe

Assessment

Supported

Score: 0.8581 under ledger-default@0.3.0 at snapshot 27745

2 of 4 review checks done · 1 counted · 1 by the author only

1 independent evidence lineage · review checks 1 of 4 · stability MEDIUM

Main unresolved issue: 3 counted evidence items have no independence review; repeats of one origin may be counted as several coverage:0a04b4cb-43ee-80e0-93e3-27f10e2aa87b

Not yet independently audited.Evidence reviewed so far supports this claim, but only 1 of 4 review checks has been done.Every quoted passage was confirmed on the page when Galedra fetched it.

Why?

Strongest counted support: The abstract directly identifies CCL11-expressing adventitial stromal cells as the memory site and states the IL-4/IL-13 and interferon-γ dependence of Ccl11 accessibility. weight 1.800000 evidence

Suppressed as dependent: The abstract directly identifies CCL11-expressing adventitial stromal cells as the memory site and gives the IL-4/IL-13 and interferon-γ regulation of Ccl11 accessibility.

Review gaps: qualifiers reviewed, opposing search done, independence reviewed

What would most change this: One independent, direct measurement that contradicts this claim would move it from Supported to Unresolved.

Hide calculation

0.8581 under ledger-default@0.3.0 at snapshot 27745 · state Supported · Review checks: 1 of 4 · stability MEDIUM · 3 sources, 1 independent lineage

Model ledger-default@0.3.0 (the default model, not the answer) · snapshot 27745 · trace sha256:b51a768ad575476b6d9a8f8b09e6fa786a8f163a534ce3eb0fa3ae61a2bf0ab4

Last changed at entry seq 25598; nothing logged since has borne on this claim.

How the number was reached

Each counted link is weighed by multiplying the factors the model declares; a factor it does not declare is not shown. Every factor name below links to what that number means.

Link	Working	Weight	Counted as
24d2e3b2 qualify	relevance MODERATE 0.6 × observation DIRECT_TEXT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	0.540000	0.000000 (non directional)
624079b3 support	relevance DIRECT 2.0 × observation DIRECT_TEXT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.800000	1.800000
9a25f3d5 support	relevance DIRECT 2.0 × observation DIRECT_TEXT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.800000	0.000000 (dependent strongest only, kept 624079b3)

prior 0.50 → log-odds 0.000000 + 1.800000 (the counted weights) = 1.800000 → probability 0.8581

Under neighbouring settings of the same model: 0.7790 to 0.9121, a spread of 0.1331.

Half-even rounding, six places for weights and four for the probability. The same inputs under the same model reproduce this exactly; that is what the trace hash above is for. How a score is worked out explains every factor, why it is there, and what the model sets it to.

Your view

Registered views

Nobody has registered a view yet.

Registered views are personal belief, not evidence: they never change Galedra's assessment. Affiliations are self-declared and shown only for groups of 5 or more.

Checked as part of

Statements this claim was broken out of. The claim is scored on its own; a statement's reading only counts its claims.

“A 2026 Nature Immunology mouse study reported that memory of an initial lung protease-hypersensitivity event was stored in CCL11-expressing adventitial...” · 1 claim · 29 September 2026

Evidence for

The abstract directly identifies CCL11-expressing adventitial stromal cells as the memory site and states the IL-4/IL-13 and interferon-γ dependence of Ccl11 accessibility.

From Long-term inhibition of protease hypersensitivity by initial immunological cross-regulation and epigenetic memory in lung stromal cells Read 2026-09-29 Relevance DIRECT Steps 0 Counted
The abstract directly identifies CCL11-expressing adventitial stromal cells as the memory site and gives the IL-4/IL-13 and interferon-γ regulation of Ccl11 accessibility.

From Long-term inhibition of protease hypersensitivity by initial immunological cross-regulation and epigenetic memory in lung stromal cells Read 2026-09-29 Relevance DIRECT Steps 0 Counted

Evidence against

None.

Qualifications

The counted passage establishes the cellular and cytokine mechanism but does not explicitly state the mouse-model population in the excerpt.

From Long-term inhibition of protease hypersensitivity by initial immunological cross-regulation and epigenetic memory in lung stromal cells Read 2026-09-29 Relevance MODERATE Steps 0 Counted

The passage supports the mechanism but is narrower on the experimental model.

Suppressed as dependent

Evidence	Group	Kept instead
961e95cc		624079b3

Inferences

Concluded from

None.

Used as a premise in

None.

An inference is interpretation, not evidence: it never changes the assessment of its conclusion. Each premise is a claim with its own evidence.

Threads

None. Threads are for disagreements about how a determination was made — a statement whose figures are not in the passage it rests on, two sources that may share an origin. Something about the world belongs in the evidence above.

Claim edges

None. Edges are stored and displayed; v0.1 does not propagate probability across them.

Review checklist

Review checks: 1 of 4

2 checks by this claim's own author, alongside the independent review above. 1 QUALIFIER CHECK · 1 EVIDENCE VERIFICATION. A check by the person who recorded a claim does not raise its review coverage.

Check	Done	By
qualifiers reviewed	no
opposing search done	no
independence reviewed	no
primary source reviewed	yes	24d2e3b2, 624079b3, 9a25f3d5

Summary

Supported. The main support is: The abstract directly identifies CCL11-expressing adventitial stromal cells as the memory site and states the IL-4/IL-13 and interferon-γ dependence of Ccl11 accessibility. b89fa2fb

1 further item repeats the same origin and is not independent evidence. 961e95cc

Qualifier: The counted passage establishes the cellular and cytokine mechanism but does not explicitly state the mouse-model population in the excerpt. e1322973

Review checks: 1 of 4. coverage:0a04b4cb-43ee-80e0-93e3-27f10e2aa87b

Generated by stub-v0.1; every sentence cites graph ids.

Contribution history

seq	event	detail
21442	APPENDED
21443	ACCEPT	AUTOMATIC_AFTER_VALIDATION
21448	LINK_EVIDENCE	by 1efd24fe (accepted)
21450	TASK_RESULT	by 1efd24fe (accepted)
25597	TASK_RESULT	by 1efd24fe (accepted)

Score trace

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  "claim": "0a04b4cb-43ee-80e0-93e3-27f10e2aa87b",
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    {
      "kept": "a754b456-1e15-8dd9-abb7-1d2f624079b3",
      "link": "d7676121-2d2f-8d66-8571-c6c09a25f3d5",
      "group": null,
      "reason": "dependent_strongest_only",
      "edition": "NAMED_OR_UNRELATED",
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      "direction": "SUPPORT",
      "magnitude": "1.800000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
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      "audit_confirmed": false,
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  ],
  "model": "ledger-default@0.3.0",
  "prior": "0.50",
  "variants": {
    "spread": "0.1331",
    "permissive": "0.9121",
    "conservative": "0.7790"
  },
  "code_hash": "sha256:c61a6fdf35a754a0d7e958df149036a083c0eaeb7d2d2e52704ec32b0c36def7",
  "contested": false,
  "stability": "MEDIUM",
  "claim_type": "OBSERVATIONAL",
  "config_hash": "sha256:86768038080b8ab5233f1e4b7aba10af05b5bb44caa432095150b90e81209809",
  "probability": "0.8581",
  "provisional": true,
  "evidence_sum": "1.800000",
  "snapshot_seq": 25598,
  "prior_log_odds": "0.000000",
  "support_groups": 1,
  "model_dependent": false,
  "review_coverage": "0.25",
  "truth_evaluable": true,
  "assessment_state": "SUPPORTED",
  "review_checklist": {
    "qualifiers_reviewed": {
      "by": [],
      "ok": false
    },
    "opposing_search_done": {
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      "ok": false
    },
    "independence_reviewed": {
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      "ok": false
    },
    "primary_source_reviewed": {
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        "3d1404f0-0ed4-8550-aaa5-d22224d2e3b2",
        "a754b456-1e15-8dd9-abb7-1d2f624079b3",
        "d7676121-2d2f-8d66-8571-c6c09a25f3d5"
      ],
      "ok": true
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  },
  "contradict_groups": 0,
  "rounding_boundary": false,
  "posterior_log_odds": "1.800000",
  "not_applicable_reason": null,
  "independence_unreviewed": 3
}