Claim

Model ledger-default@0.1.0 ledger-strict@0.1.0 ledger-default@0.2.0 ledger-strict@0.2.0 ledger-default@0.3.0 (default) ledger-strict@0.3.0 Snapshot seq

Topics

Medicine · 1efd24fe

Assessment

Why?

Strongest counted support: The primary study reports seven TF-responsive promoter classes and testing in primary CD8 T cells plus a melanoma xenograft model. weight 1.800000 evidence

Suppressed as dependent: The quoted passage directly reports testing synthetic promoters in primary human CD8 T cells and characterizing NR4A2-responsive promoters in melanoma xenograft T cells.

Review gaps: qualifiers reviewed, opposing search done, independence reviewed

What would most change this: One independent, direct measurement that contradicts this claim would move it from Supported to Unresolved.

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Checked as part of

Statements this claim was broken out of. The claim is scored on its own; a statement's reading only counts its claims.

• “A Nature Communications study developed synthetic promoters responsive to T-cell transcription factors and tested selected promoters in primary CD8 T cells...” · 2 claims · 29 September 2026

Evidence for

• The primary study reports seven TF-responsive promoter classes and testing in primary CD8 T cells plus a melanoma xenograft model.

  From A modular synthetic promoter toolkit for programmable gene control in activated and chronically stimulated T cells Read 2026-09-29 Relevance DIRECT Steps 0 Counted

  The abstract directly reports tests in primary CD8 T cells and engineered T cells in melanoma xenografts.

• The quoted passage directly reports testing synthetic promoters in primary human CD8 T cells and characterizing NR4A2-responsive promoters in melanoma xenograft T cells.

  From A modular synthetic promoter toolkit for programmable gene control in activated and chronically stimulated T cells Read 2026-09-29 Relevance DIRECT Steps 0 Counted

  The excerpt states both experimental systems and the NR4A2-responsive subset.

Evidence against

None.

Qualifications

• The study used HEK293 and Jurkat cell lines, primary human CD8 T cells, in-vitro assays, and a melanoma xenograft model.

  From A modular synthetic promoter toolkit for programmable gene control in activated and chronically stimulated T cells Read 2026-09-29 Relevance DIRECT Steps 0 Counted

  Limits cell populations, assay settings, model system, and clinical generalization.

Suppressed as dependent

Evidence	Group	Kept instead
e911b39b		bf1e4398

Inferences

Concluded from

None.

Used as a premise in

None.

An inference is interpretation, not evidence: it never changes the assessment of its conclusion. Each premise is a claim with its own evidence.

Threads

None. Threads are for disagreements about how a determination was made — a statement whose figures are not in the passage it rests on, two sources that may share an origin. Something about the world belongs in the evidence above.

Claim edges

From	Relationship	To
4c76c1ad	NARROWS	b249122a

Review checklist

Review checks: 1 of 4

2 checks by this claim's own author, alongside the independent review above. 1 QUALIFIER CHECK · 1 EVIDENCE VERIFICATION. A check by the person who recorded a claim does not raise its review coverage.

Check	Done	By
qualifiers reviewed	no
opposing search done	no
independence reviewed	no
primary source reviewed	yes	b54c0b68, 43955d4f, bf1e4398

Summary

Contribution history

seq	event	detail
21754	APPENDED
21755	ACCEPT	AUTOMATIC_AFTER_VALIDATION
21762	LINK_EVIDENCE	by 1efd24fe (accepted)
24565	TASK_RESULT	by 1efd24fe (accepted)
25626	TASK_RESULT	by 1efd24fe (accepted)

Score trace

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  "claim": "233fa232-5523-8a55-9809-b420b249122a",
  "links": [
    {
      "link": "1810685a-6e74-82e2-92fc-50d6b54c0b68",
      "group": null,
      "reason": "non_directional",
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "2037c925-0c5f-87f0-8632-55a4b9dd9acf",
      "direction": "QUALIFY",
      "magnitude": "1.800000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "DIRECT_TEXT",
      "source_type": "PRIMARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "0.000000",
      "interpretive_steps": 0
    },
    {
      "kept": "a4144c4c-5cfb-8e05-a69b-3cb1bf1e4398",
      "link": "532c423f-4e41-8f94-97ac-d4ce43955d4f",
      "group": null,
      "reason": "dependent_strongest_only",
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "634d0456-2a17-86c5-bc94-aeede911b39b",
      "direction": "SUPPORT",
      "magnitude": "1.800000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "DIRECT_TEXT",
      "source_type": "PRIMARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "0.000000",
      "interpretive_steps": 0
    },
    {
      "link": "a4144c4c-5cfb-8e05-a69b-3cb1bf1e4398",
      "group": null,
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "dd388139-d65f-8307-8206-47a786cf3f92",
      "direction": "SUPPORT",
      "magnitude": "1.800000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "DIRECT_TEXT",
      "source_type": "PRIMARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "1.800000",
      "interpretive_steps": 0
    }
  ],
  "model": "ledger-default@0.3.0",
  "prior": "0.50",
  "variants": {
    "spread": "0.1331",
    "permissive": "0.9121",
    "conservative": "0.7790"
  },
  "code_hash": "sha256:c61a6fdf35a754a0d7e958df149036a083c0eaeb7d2d2e52704ec32b0c36def7",
  "contested": false,
  "stability": "MEDIUM",
  "claim_type": "OBSERVATIONAL",
  "config_hash": "sha256:86768038080b8ab5233f1e4b7aba10af05b5bb44caa432095150b90e81209809",
  "probability": "0.8581",
  "provisional": true,
  "evidence_sum": "1.800000",
  "snapshot_seq": 25627,
  "prior_log_odds": "0.000000",
  "support_groups": 1,
  "model_dependent": false,
  "review_coverage": "0.25",
  "truth_evaluable": true,
  "assessment_state": "SUPPORTED",
  "review_checklist": {
    "qualifiers_reviewed": {
      "by": [],
      "ok": false
    },
    "opposing_search_done": {
      "by": [],
      "ok": false
    },
    "independence_reviewed": {
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      "ok": false
    },
    "primary_source_reviewed": {
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        "532c423f-4e41-8f94-97ac-d4ce43955d4f",
        "a4144c4c-5cfb-8e05-a69b-3cb1bf1e4398"
      ],
      "ok": true
    }
  },
  "contradict_groups": 0,
  "rounding_boundary": false,
  "posterior_log_odds": "1.800000",
  "not_applicable_reason": null,
  "independence_unreviewed": 3
}