Galedra
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Claim

In this real-world case-control study, prior metformin use was not associated with a statistically distinguishable difference in SARS-CoV-2 susceptibility (aOR 0.97, 95% CI 0.81–1.16).

Type QUANTITATIVE · truth-evaluable: yes · status at snapshot: ACTIVE · created seq 15952 · qualifiers {"population":"Population-based case-control study subjects","source_edition":"993d5734-c837-88d0-9417-98c46b2bdaee"}

a comma-separated series may list several propositions

Referenced 102 times: checked 1, looked up by assistants 0, viewed 82, shared 19. A count of attention, not evidence.

Topics

Public health · 1efd24fe Medicine · 1efd24fe

Assessment

Supported

Score: 0.8581 under ledger-default@0.3.0 at snapshot 27745

3 of 4 review checks done · 1 counted · 2 by the author only

1 independent evidence lineage · review checks 1 of 4 · stability MEDIUM

Main unresolved issue: 2 counted evidence items have no independence review; repeats of one origin may be counted as several coverage:3299d500-c492-850f-9d5a-963b4b2edab8

Not yet independently audited.Evidence reviewed so far supports this claim, but only 1 of 4 review checks has been done.Every quoted passage was confirmed on the page when Galedra fetched it.

Why?

Strongest counted support: The study reports no statistically distinguishable susceptibility difference, with adjusted odds ratio 0.97 and 95% confidence interval 0.81–1.16. weight 1.800000 evidence

Suppressed as dependent: The passage directly reports no susceptibility difference and gives the adjusted odds ratio and confidence interval.

Review gaps: qualifiers reviewed, opposing search done, independence reviewed

What would most change this: One independent, direct measurement that contradicts this claim would move it from Supported to Unresolved.

Hide calculation

0.8581 under ledger-default@0.3.0 at snapshot 27745 · state Supported · Review checks: 1 of 4 · stability MEDIUM · 2 sources, 1 independent lineage

Model ledger-default@0.3.0 (the default model, not the answer) · snapshot 27745 · trace sha256:3b9de4885322368474ebb1315076fa0bdd4165648bdc1d8652a6e5faa3bde015

Last changed at entry seq 15987; nothing logged since has borne on this claim.

How the number was reached

Each counted link is weighed by multiplying the factors the model declares; a factor it does not declare is not shown. Every factor name below links to what that number means.

LinkWorkingWeightCounted as
91cf3f85 support relevance DIRECT 2.0 × observation DATASET_RESULT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1 1.800000 1.800000
079a2027 support relevance DIRECT 2.0 × observation DATASET_RESULT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1 1.800000 0.000000 (dependent strongest only, kept 91cf3f85)

prior 0.50 → log-odds 0.000000 + 1.800000 (the counted weights) = 1.800000 → probability 0.8581

Under neighbouring settings of the same model: 0.7790 to 0.9121, a spread of 0.1331.

Half-even rounding, six places for weights and four for the probability. The same inputs under the same model reproduce this exactly; that is what the trace hash above is for. How a score is worked out explains every factor, why it is there, and what the model sets it to.

Your view

Sign in to register whether you agree or disagree. A view is yours alone and never changes the assessment.

Registered views

Nobody has registered a view yet.

Registered views are personal belief, not evidence: they never change Galedra's assessment. Affiliations are self-declared and shown only for groups of 5 or more.

Checked as part of

Statements this claim was broken out of. The claim is scored on its own; a statement's reading only counts its claims.

Evidence for

Evidence against

None.

Qualifications

None.

Suppressed as dependent

EvidenceGroupKept instead
948cabdb91cf3f85

Inferences

Concluded from

None.

Used as a premise in

None.

An inference is interpretation, not evidence: it never changes the assessment of its conclusion. Each premise is a claim with its own evidence.

Threads

None. Threads are for disagreements about how a determination was made — a statement whose figures are not in the passage it rests on, two sources that may share an origin. Something about the world belongs in the evidence above.

Claim edges

None. Edges are stored and displayed; v0.1 does not propagate probability across them.

Review checklist

Review checks: 1 of 4

3 checks by this claim's own author, alongside the independent review above. 1 OPPOSING EVIDENCE SEARCH · 1 QUALIFIER CHECK · 1 EVIDENCE VERIFICATION. A check by the person who recorded a claim does not raise its review coverage.

CheckDoneBy
qualifiers reviewedno
opposing search doneno
independence reviewedno
primary source reviewedyes91cf3f85, 079a2027

Summary

Supported. The main support is: The study reports no statistically distinguishable susceptibility difference, with adjusted odds ratio 0.97 and 95% confidence interval 0.81–1.16. 4ea8654c

1 further item repeats the same origin and is not independent evidence. 948cabdb

A search for evidence in the opposing direction found none. aa54156a

Review checks: 1 of 4. coverage:3299d500-c492-850f-9d5a-963b4b2edab8

Generated by stub-v0.1; every sentence cites graph ids.

Contribution history

seqeventdetail
15952APPENDED
15953ACCEPTAUTOMATIC_AFTER_VALIDATION
15962LINK_EVIDENCEby 1efd24fe (accepted)
15966TASK_RESULTby 1efd24fe (accepted)

Score trace

{
  "claim": "3299d500-c492-850f-9d5a-963b4b2edab8",
  "links": [
    {
      "link": "45526a09-6066-8f4f-aed1-510291cf3f85",
      "group": null,
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "bb52bd90-b514-8cff-ba9b-c6004ea8654c",
      "direction": "SUPPORT",
      "magnitude": "1.800000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "DATASET_RESULT",
      "source_type": "PRIMARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "1.800000",
      "interpretive_steps": 0
    },
    {
      "kept": "45526a09-6066-8f4f-aed1-510291cf3f85",
      "link": "b044a041-e237-8430-8f37-5451079a2027",
      "group": null,
      "reason": "dependent_strongest_only",
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "2cf24cbd-5e72-8bc3-9a3f-f8ac948cabdb",
      "direction": "SUPPORT",
      "magnitude": "1.800000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "DATASET_RESULT",
      "source_type": "PRIMARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "0.000000",
      "interpretive_steps": 0
    }
  ],
  "model": "ledger-default@0.3.0",
  "prior": "0.50",
  "variants": {
    "spread": "0.1331",
    "permissive": "0.9121",
    "conservative": "0.7790"
  },
  "code_hash": "sha256:c61a6fdf35a754a0d7e958df149036a083c0eaeb7d2d2e52704ec32b0c36def7",
  "contested": false,
  "stability": "MEDIUM",
  "claim_type": "QUANTITATIVE",
  "config_hash": "sha256:86768038080b8ab5233f1e4b7aba10af05b5bb44caa432095150b90e81209809",
  "probability": "0.8581",
  "provisional": true,
  "evidence_sum": "1.800000",
  "snapshot_seq": 15987,
  "prior_log_odds": "0.000000",
  "support_groups": 1,
  "model_dependent": false,
  "review_coverage": "0.25",
  "truth_evaluable": true,
  "assessment_state": "SUPPORTED",
  "review_checklist": {
    "qualifiers_reviewed": {
      "by": [],
      "ok": false
    },
    "opposing_search_done": {
      "by": [],
      "ok": false
    },
    "independence_reviewed": {
      "by": [],
      "ok": false
    },
    "primary_source_reviewed": {
      "by": [
        "45526a09-6066-8f4f-aed1-510291cf3f85",
        "b044a041-e237-8430-8f37-5451079a2027"
      ],
      "ok": true
    }
  },
  "contradict_groups": 0,
  "rounding_boundary": false,
  "posterior_log_odds": "1.800000",
  "not_applicable_reason": null,
  "independence_unreviewed": 2
}