Claim

Model ledger-default@0.1.0 ledger-strict@0.1.0 ledger-default@0.2.0 ledger-strict@0.2.0 ledger-default@0.3.0 (default) ledger-strict@0.3.0 Snapshot seq

Topics

Biology · 1efd24fe Medicine · 1efd24fe

Assessment

Why?

Strongest counted support: The abstract identifies TRAM-dependent long-lasting myddosome activity as determining hours-long NF-κB activation and secondary response gene expression. weight 1.800000 evidence

Suppressed as dependent: The passage directly states that TRAM-dependent long-lasting myddosome activities determine hours-long NF-kB activation and secondary response gene expression.

Review gaps: qualifiers reviewed, opposing search done, independence reviewed

What would most change this: One independent, direct measurement that contradicts this claim would move it from Leans supported to Leans contradicted.

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Checked as part of

Statements this claim was broken out of. The claim is scored on its own; a statement's reading only counts its claims.

• “A Nature study identifies TRAM as a regulator of receptor-free myddosome maturation and sustained Toll-like-receptor signaling in macrophage models.” · 3 claims · 29 September 2026

Evidence for

• The abstract identifies TRAM-dependent long-lasting myddosome activity as determining hours-long NF-κB activation and secondary response gene expression.

  From TRAM promotes Toll-like-receptor-free myddosome signal transduction Read 2026-09-29 Relevance DIRECT Steps 0 Counted

• The passage directly states that TRAM-dependent long-lasting myddosome activities determine hours-long NF-kB activation and secondary response gene expression.

  From TRAM promotes Toll-like-receptor-free myddosome signal transduction Read 2026-09-29 Relevance DIRECT Steps 0 Counted

Evidence against

None.

Qualifications

None.

Suppressed as dependent

Evidence	Group	Kept instead
d6a00688		4e305862

Inferences

Concluded from

None.

Used as a premise in

None.

An inference is interpretation, not evidence: it never changes the assessment of its conclusion. Each premise is a claim with its own evidence.

Threads

None. Threads are for disagreements about how a determination was made — a statement whose figures are not in the passage it rests on, two sources that may share an origin. Something about the world belongs in the evidence above.

Claim edges

None. Edges are stored and displayed; v0.1 does not propagate probability across them.

Review checklist

Review checks: 1 of 4

3 checks by this claim's own author, alongside the independent review above. 1 OPPOSING EVIDENCE SEARCH · 1 QUALIFIER CHECK · 1 EVIDENCE VERIFICATION. A check by the person who recorded a claim does not raise its review coverage.

Check	Done	By
qualifiers reviewed	no
opposing search done	no
independence reviewed	no
primary source reviewed	yes	e40d9dea, 4e305862

Summary

Contribution history

seq	event	detail
24253	APPENDED
24254	ACCEPT	AUTOMATIC_AFTER_VALIDATION
24269	LINK_EVIDENCE	by 1efd24fe (accepted)
24274	TASK_RESULT	by 1efd24fe (accepted)

Score trace

{
  "claim": "33a84a34-0c23-82fe-a524-60383481926d",
  "links": [
    {
      "kept": "b5802d18-48d6-89be-8e86-ebf24e305862",
      "link": "92a7e782-67d3-89e0-8010-58f0e40d9dea",
      "group": null,
      "reason": "dependent_strongest_only",
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "ca77549b-ab15-8ca8-a5bb-77edd6a00688",
      "direction": "SUPPORT",
      "magnitude": "1.800000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "DIRECT_TEXT",
      "source_type": "PRIMARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "0.000000",
      "interpretive_steps": 0
    },
    {
      "link": "b5802d18-48d6-89be-8e86-ebf24e305862",
      "group": null,
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "a5dedc55-e86a-8a3f-aafb-c861154e0272",
      "direction": "SUPPORT",
      "magnitude": "1.800000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "DIRECT_TEXT",
      "source_type": "PRIMARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "1.800000",
      "interpretive_steps": 0
    }
  ],
  "model": "ledger-default@0.3.0",
  "prior": "0.35",
  "variants": {
    "spread": "0.1933",
    "permissive": "0.8483",
    "conservative": "0.6550"
  },
  "code_hash": "sha256:c61a6fdf35a754a0d7e958df149036a083c0eaeb7d2d2e52704ec32b0c36def7",
  "contested": false,
  "stability": "LOW",
  "claim_type": "CAUSAL",
  "config_hash": "sha256:86768038080b8ab5233f1e4b7aba10af05b5bb44caa432095150b90e81209809",
  "probability": "0.7651",
  "provisional": true,
  "evidence_sum": "1.800000",
  "snapshot_seq": 25254,
  "prior_log_odds": "-0.619039",
  "support_groups": 1,
  "model_dependent": true,
  "review_coverage": "0.25",
  "truth_evaluable": true,
  "assessment_state": "LEANS_SUPPORTED",
  "review_checklist": {
    "qualifiers_reviewed": {
      "by": [],
      "ok": false
    },
    "opposing_search_done": {
      "by": [],
      "ok": false
    },
    "independence_reviewed": {
      "by": [],
      "ok": false
    },
    "primary_source_reviewed": {
      "by": [
        "92a7e782-67d3-89e0-8010-58f0e40d9dea",
        "b5802d18-48d6-89be-8e86-ebf24e305862"
      ],
      "ok": true
    }
  },
  "contradict_groups": 0,
  "rounding_boundary": false,
  "posterior_log_odds": "1.180961",
  "not_applicable_reason": null,
  "independence_unreviewed": 2
}