Claim

In that study, 6 of the 9 cancer-predisposition diagnoses were previously unrecognized; findings prompted tailored surveillance in 8 of 9 patients and treatment modifications in 4 of 9.

Type QUANTITATIVE · truth-evaluable: yes · status at snapshot: ACTIVE · created seq 14422 · qualifiers {"population":"Patients with identified cancer-predisposition diagnoses in the Swedish childhood acute-leukemia cohort.","denominator":"Nine patients with pathogenic germline alterations."}

28 words; atomic claims are usually under 25a conjunction joins clauses that may be separately evaluable

Referenced 134 times: checked 1, looked up by assistants 0, viewed 103, shared 30. A count of attention, not evidence.

Topics

Medicine · 1efd24fe Biology · 1efd24fe

Assessment

Supported

Score: 0.8581 under ledger-default@0.3.0 at snapshot 27745

3 of 4 review checks done · 1 counted · 2 by the author only

1 independent evidence lineage · review checks 1 of 4 · stability MEDIUM

Main unresolved issue: 3 counted evidence items have no independence review; repeats of one origin may be counted as several coverage:36c14eb0-1188-88bc-995e-3ba32d78a0cf

Not yet independently audited.Evidence reviewed so far supports this claim, but only 1 of 4 review checks has been done.A quoted passage from nature.com was not found on the page when Galedra fetched it.

Related: NARROWS incoming: Supported

Why?

Strongest counted support: The abstract reports the 181-child cohort, nine pathogenic germline findings, six previously unrecognized diagnoses, and clinical actions. weight 1.800000 evidence

Suppressed as dependent: The excerpt directly reports six previously unrecognized diagnoses, surveillance in 8 of 9 patients, and treatment modifications in 4 of 9.

Review gaps: qualifiers reviewed, opposing search done, independence reviewed

What would most change this: One independent, direct measurement that contradicts this claim would move it from Supported to Unresolved.

Hide calculation

0.8581 under ledger-default@0.3.0 at snapshot 27745 · state Supported · Review checks: 1 of 4 · stability MEDIUM · 3 sources, 1 independent lineage

Model ledger-default@0.3.0 (the default model, not the answer) · snapshot 27745 · trace sha256:08fcc477dbf4fc1c958bea8c4e9c253106a5480d707b2b45bf187b4b1b9f7c9e

Last changed at entry seq 24992; nothing logged since has borne on this claim.

How the number was reached

Each counted link is weighed by multiplying the factors the model declares; a factor it does not declare is not shown. Every factor name below links to what that number means.

Link	Working	Weight	Counted as
f43efaf3 support	relevance DIRECT 2.0 × observation DIRECT_TEXT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.800000	0.000000 (dependent strongest only, kept b1048e87)
b1048e87 support	relevance DIRECT 2.0 × observation DIRECT_TEXT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.800000	1.800000
cbb085a9 qualify	relevance DIRECT 2.0 × observation DIRECT_TEXT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.800000	0.000000 (non directional)

prior 0.50 → log-odds 0.000000 + 1.800000 (the counted weights) = 1.800000 → probability 0.8581

Under neighbouring settings of the same model: 0.7790 to 0.9121, a spread of 0.1331.

Half-even rounding, six places for weights and four for the probability. The same inputs under the same model reproduce this exactly; that is what the trace hash above is for. How a score is worked out explains every factor, why it is there, and what the model sets it to.

Your view

Registered views

Nobody has registered a view yet.

Registered views are personal belief, not evidence: they never change Galedra's assessment. Affiliations are self-declared and shown only for groups of 5 or more.

Checked as part of

Statements this claim was broken out of. The claim is scored on its own; a statement's reading only counts its claims.

“A Swedish nationwide prospective study of 181 children with acute leukemia found pathogenic germline alterations in 9 patients (5%), including six previously...” · 2 claims · 28 September 2026

Evidence for

The abstract reports the 181-child cohort, nine pathogenic germline findings, six previously unrecognized diagnoses, and clinical actions.

From Diagnostic yield of cancer predisposition in a nationwide prospective childhood acute leukemia cohort Read 2026-09-29 Relevance DIRECT Steps 0 Counted

The abstract directly states prior recognition and resulting surveillance and treatment changes.
The excerpt directly reports six previously unrecognized diagnoses, surveillance in 8 of 9 patients, and treatment modifications in 4 of 9.

From Diagnostic yield of cancer predisposition in a nationwide prospective childhood acute leukemia cohort Read 2026-09-29 Relevance DIRECT Steps 0 Counted

Every quantitative component of the claim appears explicitly in the quoted passage.

Evidence against

None.

Qualifications

The abstract defines the 181-child cohort and identifies nine patients with pathogenic germline alterations as the denominator for the reported outcomes.

From Diagnostic yield of cancer predisposition in a nationwide prospective childhood acute leukemia cohort Read 2026-09-29 Relevance DIRECT Steps 0 Counted

Makes the cohort and denominator explicit for the reported fractions.

Suppressed as dependent

Evidence	Group	Kept instead
05468c7c		b1048e87

Inferences

Concluded from

None.

Used as a premise in

None.

An inference is interpretation, not evidence: it never changes the assessment of its conclusion. Each premise is a claim with its own evidence.

Threads

None. Threads are for disagreements about how a determination was made — a statement whose figures are not in the passage it rests on, two sources that may share an origin. Something about the world belongs in the evidence above.

Claim edges

From	Relationship	To
42ed51e6	NARROWS	2d78a0cf

Review checklist

Review checks: 1 of 4

3 checks by this claim's own author, alongside the independent review above. 1 OPPOSING EVIDENCE SEARCH · 1 QUALIFIER CHECK · 1 EVIDENCE VERIFICATION. A check by the person who recorded a claim does not raise its review coverage.

Check	Done	By
qualifiers reviewed	no
opposing search done	no
independence reviewed	no
primary source reviewed	yes	f43efaf3, b1048e87, cbb085a9

Summary

Supported. The main support is: The abstract reports the 181-child cohort, nine pathogenic germline findings, six previously unrecognized diagnoses, and clinical actions. 86aab2a2

1 further item repeats the same origin and is not independent evidence. 05468c7c

Qualifier: The abstract defines the 181-child cohort and identifies nine patients with pathogenic germline alterations as the denominator for the reported outcomes. 3cf2077e

A narrower version of this claim is supported. 42ed51e6

A search for evidence in the opposing direction found none. 562a1f8b

Review checks: 1 of 4. coverage:36c14eb0-1188-88bc-995e-3ba32d78a0cf

Generated by stub-v0.1; every sentence cites graph ids.

Contribution history

seq	event	detail
14422	APPENDED
14423	ACCEPT	AUTOMATIC_AFTER_VALIDATION
14434	LINK_EVIDENCE	by 1efd24fe (accepted)
14438	TASK_RESULT	by 1efd24fe (accepted)
14639	TASK_RESULT	by 1efd24fe (accepted)

Score trace

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  "claim": "36c14eb0-1188-88bc-995e-3ba32d78a0cf",
  "links": [
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      "kept": "70f1d7cc-099b-8f55-8652-8d7db1048e87",
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      "group": null,
      "reason": "dependent_strongest_only",
      "edition": "NAMED_OR_UNRELATED",
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      "direction": "SUPPORT",
      "magnitude": "1.800000",
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      "audit_confirmed": false,
      "effective_weight": "0.000000",
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      "group": null,
      "edition": "NAMED_OR_UNRELATED",
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      "interpretive_steps": 0
    },
    {
      "link": "77d00b10-44fa-8d65-9e3f-ef1fcbb085a9",
      "group": null,
      "reason": "non_directional",
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "21e034db-4d83-8486-b0b0-4e873cf2077e",
      "direction": "QUALIFY",
      "magnitude": "1.800000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
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      "audit_confirmed": false,
      "effective_weight": "0.000000",
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  ],
  "model": "ledger-default@0.3.0",
  "prior": "0.50",
  "variants": {
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    "permissive": "0.9121",
    "conservative": "0.7790"
  },
  "code_hash": "sha256:c61a6fdf35a754a0d7e958df149036a083c0eaeb7d2d2e52704ec32b0c36def7",
  "contested": false,
  "stability": "MEDIUM",
  "claim_type": "QUANTITATIVE",
  "config_hash": "sha256:86768038080b8ab5233f1e4b7aba10af05b5bb44caa432095150b90e81209809",
  "probability": "0.8581",
  "provisional": true,
  "evidence_sum": "1.800000",
  "snapshot_seq": 24992,
  "prior_log_odds": "0.000000",
  "support_groups": 1,
  "model_dependent": false,
  "review_coverage": "0.25",
  "truth_evaluable": true,
  "assessment_state": "SUPPORTED",
  "review_checklist": {
    "qualifiers_reviewed": {
      "by": [],
      "ok": false
    },
    "opposing_search_done": {
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      "ok": false
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    "independence_reviewed": {
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      "ok": false
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    "primary_source_reviewed": {
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        "021700e5-e846-880e-b29e-8d14f43efaf3",
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        "77d00b10-44fa-8d65-9e3f-ef1fcbb085a9"
      ],
      "ok": true
    }
  },
  "contradict_groups": 0,
  "rounding_boundary": false,
  "posterior_log_odds": "1.800000",
  "not_applicable_reason": null,
  "independence_unreviewed": 3
}