Claim

Model ledger-default@0.1.0 ledger-strict@0.1.0 ledger-default@0.2.0 ledger-strict@0.2.0 ledger-default@0.3.0 (default) ledger-strict@0.3.0 Snapshot seq

Topics

Not filed under any topic yet.

Assessment

Why?

Strongest counted support: The study reports a nationwide prospective 181-child cohort, nine pathogenic germline cases, and the stated 6/9, 8/9, and 4/9 outcomes. weight 1.800000 evidence

Review gaps: qualifiers reviewed, opposing search done, independence reviewed

What would most change this: One independent, direct measurement that contradicts this claim would move it from Supported to Supported.

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Checked as part of

Statements this claim was broken out of. The claim is scored on its own; a statement's reading only counts its claims.

• “The reported clinical-utility figures came from a nationwide prospective population-based study of 181 children with acute leukemia, with nine patients...” · 1 claim · 29 September 2026

Evidence for

• The study reports a nationwide prospective 181-child cohort, nine pathogenic germline cases, and the stated 6/9, 8/9, and 4/9 outcomes.

  From Diagnostic yield of cancer predisposition in a nationwide prospective childhood acute leukemia cohort Read 2026-09-28 Relevance DIRECT Steps 0 Counted

  Directly supports the newly narrowed cohort and denominator claim; it is the primary study report.

• The primary Nature Communications study directly reports the 181-child cohort, nine pathogenic findings, and the clinical-utility outcomes.

  From Diagnostic yield of cancer predisposition in a nationwide prospective childhood acute leukemia cohort Read 2026-09-29 Relevance DIRECT Steps 0 Counted

  Primary nationwide prospective pediatric-oncology study; distinct clinical-genomics topic.

Evidence against

None.

Qualifications

None.

Suppressed as dependent

None.

Inferences

Concluded from

None.

Used as a premise in

None.

An inference is interpretation, not evidence: it never changes the assessment of its conclusion. Each premise is a claim with its own evidence.

Threads

None. Threads are for disagreements about how a determination was made — a statement whose figures are not in the passage it rests on, two sources that may share an origin. Something about the world belongs in the evidence above.

Claim edges

From	Relationship	To
42ed51e6	NARROWS	2d78a0cf

Review checklist

Review checks: 1 of 4

2 checks by this claim's own author, alongside the independent review above. 1 OPPOSING EVIDENCE SEARCH · 1 QUALIFIER CHECK. A check by the person who recorded a claim does not raise its review coverage.

Check	Done	By
qualifiers reviewed	no
opposing search done	no
independence reviewed	no
primary source reviewed	yes	9d289b50, 37d25b33

Summary

Contribution history

seq	event	detail
14639	APPENDED
14640	ACCEPT	AUTOMATIC_AFTER_VALIDATION
14643	TASK_RESULT	by 1efd24fe (accepted)
17434	LINK_EVIDENCE	by 1efd24fe (accepted)

Score trace

{
  "claim": "3e7dfd86-90fc-805f-9de4-6d4c42ed51e6",
  "links": [
    {
      "link": "157d9046-28d0-8e70-a3a4-a93c9d289b50",
      "group": null,
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "dfbb5cc0-01f8-88dc-b533-be10105edc39",
      "direction": "SUPPORT",
      "magnitude": "1.800000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "DIRECT_TEXT",
      "source_type": "PRIMARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "1.800000",
      "interpretive_steps": 0
    },
    {
      "link": "f05e2ba2-b974-88aa-bf83-491a37d25b33",
      "group": null,
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "1f0eff89-63c4-84cc-b507-ba3548e4fdac",
      "direction": "SUPPORT",
      "magnitude": "1.800000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "DIRECT_TEXT",
      "source_type": "PRIMARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "1.800000",
      "interpretive_steps": 0
    }
  ],
  "model": "ledger-default@0.3.0",
  "prior": "0.50",
  "variants": {
    "spread": "0.0653",
    "permissive": "0.9908",
    "conservative": "0.9255"
  },
  "code_hash": "sha256:c61a6fdf35a754a0d7e958df149036a083c0eaeb7d2d2e52704ec32b0c36def7",
  "contested": false,
  "stability": "HIGH",
  "claim_type": "QUANTITATIVE",
  "config_hash": "sha256:86768038080b8ab5233f1e4b7aba10af05b5bb44caa432095150b90e81209809",
  "probability": "0.9734",
  "provisional": true,
  "evidence_sum": "3.600000",
  "snapshot_seq": 17435,
  "prior_log_odds": "0.000000",
  "support_groups": 2,
  "model_dependent": false,
  "review_coverage": "0.25",
  "truth_evaluable": true,
  "assessment_state": "SUPPORTED",
  "review_checklist": {
    "qualifiers_reviewed": {
      "by": [],
      "ok": false
    },
    "opposing_search_done": {
      "by": [],
      "ok": false
    },
    "independence_reviewed": {
      "by": [],
      "ok": false
    },
    "primary_source_reviewed": {
      "by": [
        "157d9046-28d0-8e70-a3a4-a93c9d289b50",
        "f05e2ba2-b974-88aa-bf83-491a37d25b33"
      ],
      "ok": true
    }
  },
  "contradict_groups": 0,
  "rounding_boundary": false,
  "posterior_log_odds": "3.600000",
  "not_applicable_reason": null,
  "independence_unreviewed": 2
}