Claim

Model ledger-default@0.1.0 ledger-strict@0.1.0 ledger-default@0.2.0 ledger-strict@0.2.0 ledger-default@0.3.0 (default) ledger-strict@0.3.0 Snapshot seq

Topics

Public health · 1efd24fe Medicine · 1efd24fe

Assessment

Why?

Strongest counted support: The trial reports high specificity, substantially lower episode sensitivity, descriptive performance analyses, and a missed primary late-stage-cancer endpoint. weight 2.000000 evidence

Suppressed as dependent: The passage directly reports the specificity, episode sensitivity, descriptive-analysis caveat, and missed primary endpoint.

Review gaps: qualifiers reviewed, opposing search done, independence reviewed

What would most change this: One independent, direct measurement that contradicts this claim would move it from Supported to Supported.

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Checked as part of

Statements this claim was broken out of. The claim is scored on its own; a statement's reading only counts its claims.

• “In the NHS-Galleri trial's evaluable intervention participants across three annual rounds, the multi-cancer early-detection test had 99.50–99.60% specificity...” · 1 claim · 29 September 2026
• “In the NHS-Galleri trial's evaluable intervention participants across three annual rounds, the multi-cancer early-detection test had 99.50–99.60% specificity...” · 1 claim · 29 September 2026
• “In the NHS-Galleri trial's evaluable intervention participants across three annual rounds, the multi-cancer early-detection test had 99.50–99.60% specificity...” · 1 claim · 29 September 2026

Evidence for

• The trial reports high specificity, substantially lower episode sensitivity, descriptive performance analyses, and a missed primary late-stage-cancer endpoint.

  From Performance of a multi-cancer early detection test in the randomized controlled NHS-Galleri trial Read 2026-09-29 Relevance DIRECT Steps 0 Counted

• The passage directly reports the specificity, episode sensitivity, descriptive-analysis caveat, and missed primary endpoint.

  From Performance of a multi-cancer early detection test in the randomized controlled NHS-Galleri trial Read 2026-09-29 Relevance DIRECT Steps 0 Counted

• Independent reporting repeats the trial's high specificity, low episode-sensitivity range, and failure to reduce late-stage cancers.

  From The Galleri blood test found 937 cancers in the NHS trial but missed most of the rest Read 2026-09-29 Relevance STRONG Steps 0 Counted

  Independent secondary analysis of the Nature Medicine trial; it also emphasizes that performance is not equivalent to clinical benefit.

• The primary Nature Medicine report directly gives the three-round specificity and all-cancer episode-sensitivity ranges in the claim.

  From Performance of a multi-cancer early detection test in the randomized controlled NHS-Galleri trial Read 2026-09-29 Relevance DIRECT Steps 0 Counted

  Primary randomized controlled NHS-Galleri trial report; the claim also preserves the limitation that the primary late-stage endpoint was not met.

Evidence against

None.

Qualifications

• The reported episode sensitivity is round-specific and defined over a 12-month primary-cancer follow-up window, not absolute sensitivity.

  From Performance of a multi-cancer early detection test in the randomized controlled NHS-Galleri trial Read 2026-09-29 Relevance DIRECT Steps 0 Counted

  Adds denominator, jurisdiction, round-specific follow-up, and episode-sensitivity definition.

Suppressed as dependent

Evidence	Group	Kept instead
6b65a56b		f5177b43

Inferences

Concluded from

None.

Used as a premise in

None.

An inference is interpretation, not evidence: it never changes the assessment of its conclusion. Each premise is a claim with its own evidence.

Threads

None. Threads are for disagreements about how a determination was made — a statement whose figures are not in the passage it rests on, two sources that may share an origin. Something about the world belongs in the evidence above.

Claim edges

None. Edges are stored and displayed; v0.1 does not propagate probability across them.

Review checklist

Review checks: 1 of 4

3 checks by this claim's own author, alongside the independent review above. 1 OPPOSING EVIDENCE SEARCH · 1 QUALIFIER CHECK · 1 EVIDENCE VERIFICATION. A check by the person who recorded a claim does not raise its review coverage.

Check	Done	By
qualifiers reviewed	no
opposing search done	no
independence reviewed	no
primary source reviewed	yes	5eb301f6, d20e59bd, c025b18d, f5177b43

Summary

Contribution history

seq	event	detail
16351	APPENDED
16352	ACCEPT	AUTOMATIC_AFTER_VALIDATION
16357	LINK_EVIDENCE	by 1efd24fe (accepted)
16397	TASK_RESULT	by 1efd24fe (accepted)
16441	LINK_EVIDENCE	by 1efd24fe (accepted)
16853	LINK_EVIDENCE	by 1efd24fe (accepted)
17654	TASK_RESULT	by 1efd24fe (accepted)