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Claim

In an open-label pilot of 30 adults with Crohn’s disease, a single colonoscopic fecal microbiota transplant was associated with mucosal adherent-invasive E. coli decolonization in all 8 evaluable baseline-positive patients, with no FMT-related serious adverse events.

Type QUANTITATIVE · truth-evaluable: yes · status at snapshot: ACTIVE · created seq 17719

36 words; atomic claims are usually under 25a comma-separated series may list several propositions

Referenced 128 times: checked 2, looked up by assistants 0, viewed 85, shared 41. A count of attention, not evidence.

Topics

Medicine · 1efd24fe Health · 1efd24fe

Assessment

Supported

Score: 0.9468 under ledger-default@0.3.0 at snapshot 27745

2 of 4 review checks done · 1 counted · 1 by the author only

2 independent evidence lineages · review checks 1 of 4 · stability HIGH

Main unresolved issue: 4 counted evidence items have no independence review; repeats of one origin may be counted as several coverage:4fd75235-d8aa-8171-bdde-18411fd5a207

Not yet independently audited.Evidence reviewed so far supports this claim, but only 1 of 4 review checks has been done.A quoted passage from emjreviews.com and nature.com was not found on the page when Galedra fetched it.

Why?

Strongest counted support: The pilot reported decolonization in all eight evaluable baseline-positive patients and no FMT-related serious adverse events. weight 1.800000 evidence

Suppressed as dependent: The packet directly supports the 30-person pilot, all-eight decolonization result, and absence of serious FMT-related adverse events.

Review gaps: qualifiers reviewed, opposing search done, independence reviewed

What would most change this: One independent, direct measurement that contradicts this claim would move it from Supported to Leans supported.

Hide calculation

0.9468 under ledger-default@0.3.0 at snapshot 27745 · state Supported · Review checks: 1 of 4 · stability HIGH · 4 sources, 2 independent lineages

Model ledger-default@0.3.0 (the default model, not the answer) · snapshot 27745 · trace sha256:1284263075f9c7b69dbbfc42e1d4f52bc8a550ee9f2e18adf156888261f06095

Last changed at entry seq 25359; nothing logged since has borne on this claim.

How the number was reached

Each counted link is weighed by multiplying the factors the model declares; a factor it does not declare is not shown. Every factor name below links to what that number means.

LinkWorkingWeightCounted as
1f146007 qualify relevance DIRECT 2.0 × observation MEASUREMENT 1.0 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1 2.000000 0.000000 (non directional)
53d7baa4 support relevance STRONG 1.2 × observation DIRECT_TEXT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1 1.080000 1.080000
6070466d support relevance DIRECT 2.0 × observation DATASET_RESULT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1 1.800000 1.800000
92973c1a support relevance DIRECT 2.0 × observation DATASET_RESULT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1 1.800000 0.000000 (dependent strongest only, kept 6070466d)

prior 0.50 → log-odds 0.000000 + 2.880000 (the counted weights) = 2.880000 → probability 0.9468

Under neighbouring settings of the same model: 0.8825 to 0.9769, a spread of 0.0944.

Half-even rounding, six places for weights and four for the probability. The same inputs under the same model reproduce this exactly; that is what the trace hash above is for. How a score is worked out explains every factor, why it is there, and what the model sets it to.

Your view

Sign in to register whether you agree or disagree. A view is yours alone and never changes the assessment.

Registered views

Nobody has registered a view yet.

Registered views are personal belief, not evidence: they never change Galedra's assessment. Affiliations are self-declared and shown only for groups of 5 or more.

Checked as part of

Statements this claim was broken out of. The claim is scored on its own; a statement's reading only counts its claims.

Evidence for

Evidence against

None.

Qualifications

Suppressed as dependent

EvidenceGroupKept instead
e92850036070466d

Inferences

Concluded from

None.

Used as a premise in

None.

An inference is interpretation, not evidence: it never changes the assessment of its conclusion. Each premise is a claim with its own evidence.

Threads

None. Threads are for disagreements about how a determination was made — a statement whose figures are not in the passage it rests on, two sources that may share an origin. Something about the world belongs in the evidence above.

Claim edges

None. Edges are stored and displayed; v0.1 does not propagate probability across them.

Review checklist

Review checks: 1 of 4

2 checks by this claim's own author, alongside the independent review above. 1 QUALIFIER CHECK · 1 EVIDENCE VERIFICATION. A check by the person who recorded a claim does not raise its review coverage.

CheckDoneBy
qualifiers reviewedno
opposing search doneno
independence reviewedno
primary source reviewedyes1f146007, 6070466d, 92973c1a

Summary

Supported. The main support is: Independent gastroenterology coverage corroborates decolonization in all eight evaluable baseline-positive patients and the absence of serious FMT-related adverse events. 80f532f9

1 further item repeats the same origin and is not independent evidence. e9285003

Qualifier: The decolonization result was a 12-week, mucosal-assay endpoint in eight evaluable baseline-positive adults selected for serum anti-E. coli antibody positivity. 4b870973

Review checks: 1 of 4. coverage:4fd75235-d8aa-8171-bdde-18411fd5a207

Generated by stub-v0.1; every sentence cites graph ids.

Contribution history

seqeventdetail
17719APPENDED
17720ACCEPTAUTOMATIC_AFTER_VALIDATION
17725LINK_EVIDENCEby 1efd24fe (accepted)
17733LINK_EVIDENCEby 1efd24fe (accepted)
17739TASK_RESULTby 1efd24fe (accepted)
25358TASK_RESULTby 1efd24fe (accepted)

Score trace

{
  "claim": "4fd75235-d8aa-8171-bdde-18411fd5a207",
  "links": [
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      "link": "230b478a-65d0-8fc1-991a-6bce1f146007",
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      "direction": "QUALIFY",
      "magnitude": "2.000000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
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      "observation": "MEASUREMENT",
      "source_type": "PRIMARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "0.000000",
      "interpretive_steps": 0
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    {
      "link": "b0598f96-a71d-8f77-bb4b-78cc53d7baa4",
      "group": null,
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      "direction": "SUPPORT",
      "magnitude": "1.080000",
      "relevance": "STRONG",
      "extraction": "UNVERIFIED",
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      "source_type": "SECONDARY_TEXT",
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    {
      "link": "b12e27a7-59eb-8548-bd50-52306070466d",
      "group": null,
      "edition": "NAMED_OR_UNRELATED",
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      "extraction": "UNVERIFIED",
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      "kept": "b12e27a7-59eb-8548-bd50-52306070466d",
      "link": "e8aae7ac-c0ed-8e79-bd44-242092973c1a",
      "group": null,
      "reason": "dependent_strongest_only",
      "edition": "NAMED_OR_UNRELATED",
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      "direction": "SUPPORT",
      "magnitude": "1.800000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
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      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "0.000000",
      "interpretive_steps": 0
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  ],
  "model": "ledger-default@0.3.0",
  "prior": "0.50",
  "variants": {
    "spread": "0.0944",
    "permissive": "0.9769",
    "conservative": "0.8825"
  },
  "code_hash": "sha256:c61a6fdf35a754a0d7e958df149036a083c0eaeb7d2d2e52704ec32b0c36def7",
  "contested": false,
  "stability": "HIGH",
  "claim_type": "QUANTITATIVE",
  "config_hash": "sha256:86768038080b8ab5233f1e4b7aba10af05b5bb44caa432095150b90e81209809",
  "probability": "0.9468",
  "provisional": true,
  "evidence_sum": "2.880000",
  "snapshot_seq": 25359,
  "prior_log_odds": "0.000000",
  "support_groups": 2,
  "model_dependent": false,
  "review_coverage": "0.25",
  "truth_evaluable": true,
  "assessment_state": "SUPPORTED",
  "review_checklist": {
    "qualifiers_reviewed": {
      "by": [],
      "ok": false
    },
    "opposing_search_done": {
      "by": [],
      "ok": false
    },
    "independence_reviewed": {
      "by": [],
      "ok": false
    },
    "primary_source_reviewed": {
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        "e8aae7ac-c0ed-8e79-bd44-242092973c1a"
      ],
      "ok": true
    }
  },
  "contradict_groups": 0,
  "rounding_boundary": false,
  "posterior_log_odds": "2.880000",
  "not_applicable_reason": null,
  "independence_unreviewed": 4
}