Claim

The study developed WHOLISTIC, a method for imaging second-timescale activity across the entire vertebrate body at cellular resolution.

Type OBSERVATIONAL · truth-evaluable: yes · status at snapshot: ACTIVE · created seq 22150

Referenced 113 times: checked 2, looked up by assistants 0, viewed 69, shared 42. A count of attention, not evidence.

Topics

Biology · 1efd24fe Neuroscience · 1efd24fe

Assessment

Supported

Score: 0.9468 under ledger-default@0.3.0 at snapshot 27745

2 of 4 review checks done · 1 counted · 1 by the author only

2 independent evidence lineages · review checks 1 of 4 · stability HIGH

Main unresolved issue: 3 counted evidence items have no independence review; repeats of one origin may be counted as several coverage:60502f5e-fdc3-81d7-be05-945345be07b2

Not yet independently audited.Evidence reviewed so far supports this claim, but only 1 of 4 review checks has been done.A quoted passage from nature.com was not found on the page when Galedra fetched it.

Why?

Strongest counted support: The primary study directly defines WHOLISTIC as body-wide cellular-resolution imaging at second-timescale activity. weight 1.800000 evidence

Suppressed as dependent: The quoted passage directly defines WHOLISTIC as imaging second-timescale cellular activity across the entire vertebrate body at cellular resolution.

Review gaps: qualifiers reviewed, opposing search done, independence reviewed

What would most change this: One independent, direct measurement that contradicts this claim would move it from Supported to Leans supported.

Hide calculation

0.9468 under ledger-default@0.3.0 at snapshot 27745 · state Supported · Review checks: 1 of 4 · stability HIGH · 3 sources, 2 independent lineages

Model ledger-default@0.3.0 (the default model, not the answer) · snapshot 27745 · trace sha256:5a7ce959ff874351c26252f801694b73c75c102daa4dbc4eaf6f52a0b630fef7

Last changed at entry seq 25639; nothing logged since has borne on this claim.

How the number was reached

Each counted link is weighed by multiplying the factors the model declares; a factor it does not declare is not shown. Every factor name below links to what that number means.

Link	Working	Weight	Counted as
5be93f2e support	relevance DIRECT 2.0 × observation DIRECT_TEXT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.800000	1.800000
214fe5e9 support	relevance STRONG 1.2 × observation DIRECT_TEXT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.080000	1.080000
236aa6d5 support	relevance DIRECT 2.0 × observation DIRECT_TEXT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.800000	0.000000 (dependent strongest only, kept 5be93f2e)

prior 0.50 → log-odds 0.000000 + 2.880000 (the counted weights) = 2.880000 → probability 0.9468

Under neighbouring settings of the same model: 0.8825 to 0.9769, a spread of 0.0944.

Half-even rounding, six places for weights and four for the probability. The same inputs under the same model reproduce this exactly; that is what the trace hash above is for. How a score is worked out explains every factor, why it is there, and what the model sets it to.

Your view

Registered views

Nobody has registered a view yet.

Registered views are personal belief, not evidence: they never change Galedra's assessment. Affiliations are self-declared and shown only for groups of 5 or more.

Checked as part of

Statements this claim was broken out of. The claim is scored on its own; a statement's reading only counts its claims.

“The study developed WHOLISTIC, a method for imaging second-timescale activity across the entire vertebrate body at cellular resolution.” · 1 claim · 29 September 2026
“A 2026 Nature study introduced WHOLISTIC for cellular-resolution imaging of body-wide physiology in transparent vertebrates.” · 3 claims · 29 September 2026

Evidence for

The primary study directly defines WHOLISTIC as body-wide cellular-resolution imaging at second-timescale activity.

From Imaging cellular activity across all organs reveals body-wide circuits Read 2026-09-29 Relevance DIRECT Steps 0 Counted

Exact abstract method statement.
The primary paper demonstrates the method in a transparent vertebrate model and extends it to adult Danionella as proof of concept.

From Imaging cellular activity across all organs reveals body-wide circuits Read 2026-09-29 Relevance STRONG Steps 0 Counted

Additional primary-text demonstration detail.
The quoted passage directly defines WHOLISTIC as imaging second-timescale cellular activity across the entire vertebrate body at cellular resolution.

From Imaging cellular activity across all organs reveals body-wide circuits Read 2026-09-29 Relevance DIRECT Steps 0 Counted

The excerpt states the method name, temporal scale, organismal scope, and resolution.

Evidence against

None.

Qualifications

None.

Suppressed as dependent

Evidence	Group	Kept instead
59c38f0c		5be93f2e

Inferences

Concluded from

None.

Used as a premise in

None.

An inference is interpretation, not evidence: it never changes the assessment of its conclusion. Each premise is a claim with its own evidence.

Threads

None. Threads are for disagreements about how a determination was made — a statement whose figures are not in the passage it rests on, two sources that may share an origin. Something about the world belongs in the evidence above.

Claim edges

None. Edges are stored and displayed; v0.1 does not propagate probability across them.

Review checklist

Review checks: 1 of 4

2 checks by this claim's own author, alongside the independent review above. 1 QUALIFIER CHECK · 1 EVIDENCE VERIFICATION. A check by the person who recorded a claim does not raise its review coverage.

Check	Done	By
qualifiers reviewed	no
opposing search done	no
independence reviewed	no
primary source reviewed	yes	5be93f2e, 214fe5e9, 236aa6d5

Summary

Supported. The main support is: The primary study directly defines WHOLISTIC as body-wide cellular-resolution imaging at second-timescale activity. ae90a50d

1 further item repeats the same origin and is not independent evidence. 59c38f0c

Review checks: 1 of 4. coverage:60502f5e-fdc3-81d7-be05-945345be07b2

Generated by stub-v0.1; every sentence cites graph ids.

Contribution history

seq	event	detail
22150	APPENDED
22151	ACCEPT	AUTOMATIC_AFTER_VALIDATION
22168	LINK_EVIDENCE	by 1efd24fe (accepted)
22228	LINK_EVIDENCE	by 1efd24fe (accepted)
24577	TASK_RESULT	by 1efd24fe (accepted)

Score trace

{
  "claim": "60502f5e-fdc3-81d7-be05-945345be07b2",
  "links": [
    {
      "link": "23a9e613-2bc5-8424-92a2-a8f25be93f2e",
      "group": null,
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "d712b142-b0b1-819c-8ea0-43eaae90a50d",
      "direction": "SUPPORT",
      "magnitude": "1.800000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "DIRECT_TEXT",
      "source_type": "PRIMARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "1.800000",
      "interpretive_steps": 0
    },
    {
      "link": "575af1ac-6aae-80f3-9f08-f1d8214fe5e9",
      "group": null,
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "7d47cb8f-d046-8e6b-913f-cf76f159b449",
      "direction": "SUPPORT",
      "magnitude": "1.080000",
      "relevance": "STRONG",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
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      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "1.080000",
      "interpretive_steps": 0
    },
    {
      "kept": "23a9e613-2bc5-8424-92a2-a8f25be93f2e",
      "link": "bf0b96d0-1b01-82d7-9014-06e4236aa6d5",
      "group": null,
      "reason": "dependent_strongest_only",
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "f228598d-4012-8be9-acae-02eb59c38f0c",
      "direction": "SUPPORT",
      "magnitude": "1.800000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "DIRECT_TEXT",
      "source_type": "PRIMARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "0.000000",
      "interpretive_steps": 0
    }
  ],
  "model": "ledger-default@0.3.0",
  "prior": "0.50",
  "variants": {
    "spread": "0.0944",
    "permissive": "0.9769",
    "conservative": "0.8825"
  },
  "code_hash": "sha256:c61a6fdf35a754a0d7e958df149036a083c0eaeb7d2d2e52704ec32b0c36def7",
  "contested": false,
  "stability": "HIGH",
  "claim_type": "OBSERVATIONAL",
  "config_hash": "sha256:86768038080b8ab5233f1e4b7aba10af05b5bb44caa432095150b90e81209809",
  "probability": "0.9468",
  "provisional": true,
  "evidence_sum": "2.880000",
  "snapshot_seq": 25639,
  "prior_log_odds": "0.000000",
  "support_groups": 2,
  "model_dependent": false,
  "review_coverage": "0.25",
  "truth_evaluable": true,
  "assessment_state": "SUPPORTED",
  "review_checklist": {
    "qualifiers_reviewed": {
      "by": [],
      "ok": false
    },
    "opposing_search_done": {
      "by": [],
      "ok": false
    },
    "independence_reviewed": {
      "by": [],
      "ok": false
    },
    "primary_source_reviewed": {
      "by": [
        "23a9e613-2bc5-8424-92a2-a8f25be93f2e",
        "575af1ac-6aae-80f3-9f08-f1d8214fe5e9",
        "bf0b96d0-1b01-82d7-9014-06e4236aa6d5"
      ],
      "ok": true
    }
  },
  "contradict_groups": 0,
  "rounding_boundary": false,
  "posterior_log_odds": "2.880000",
  "not_applicable_reason": null,
  "independence_unreviewed": 3
}