Claim

Model ledger-default@0.1.0 ledger-strict@0.1.0 ledger-default@0.2.0 ledger-strict@0.2.0 ledger-default@0.3.0 (default) ledger-strict@0.3.0 Snapshot seq

Topics

Biology · 1efd24fe Medicine · 1efd24fe

Assessment

Why?

Strongest counted support: The abstract states that chemically dissociating cytosolic myddosomes disrupted inflammatory activity in vitro and in vivo. weight 1.800000 evidence

Suppressed as dependent: The excerpt directly states that chemical dissociation of cytosolic myddosomes disrupted inflammatory activities of TLR-stimulated cells in vitro and in vivo.

Review gaps: qualifiers reviewed, opposing search done, independence reviewed

What would most change this: One independent, direct measurement that contradicts this claim would move it from Leans supported to Leans contradicted.

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Checked as part of

Statements this claim was broken out of. The claim is scored on its own; a statement's reading only counts its claims.

• “A Nature study identifies TRAM as a regulator of receptor-free myddosome maturation and sustained Toll-like-receptor signaling in macrophage models.” · 3 claims · 29 September 2026

Evidence for

• The abstract states that chemically dissociating cytosolic myddosomes disrupted inflammatory activity in vitro and in vivo.

  From TRAM promotes Toll-like-receptor-free myddosome signal transduction Read 2026-09-29 Relevance DIRECT Steps 0 Counted

• The excerpt directly states that chemical dissociation of cytosolic myddosomes disrupted inflammatory activities of TLR-stimulated cells in vitro and in vivo.

  From TRAM promotes Toll-like-receptor-free myddosome signal transduction Read 2026-09-29 Relevance DIRECT Steps 0 Counted

  The passage exactly matches the intervention, model scope, and inflammatory-activity outcome.

Evidence against

None.

Qualifications

None.

Suppressed as dependent

Evidence	Group	Kept instead
eba456bb		d113db42

Inferences

Concluded from

None.

Used as a premise in

None.

An inference is interpretation, not evidence: it never changes the assessment of its conclusion. Each premise is a claim with its own evidence.

Threads

None. Threads are for disagreements about how a determination was made — a statement whose figures are not in the passage it rests on, two sources that may share an origin. Something about the world belongs in the evidence above.

Claim edges

None. Edges are stored and displayed; v0.1 does not propagate probability across them.

Review checklist

Review checks: 1 of 4

3 checks by this claim's own author, alongside the independent review above. 1 OPPOSING EVIDENCE SEARCH · 1 QUALIFIER CHECK · 1 EVIDENCE VERIFICATION. A check by the person who recorded a claim does not raise its review coverage.

Check	Done	By
qualifiers reviewed	no
opposing search done	no
independence reviewed	no
primary source reviewed	yes	ab61a06f, d113db42

Summary

Contribution history

seq	event	detail
24257	APPENDED
24258	ACCEPT	AUTOMATIC_AFTER_VALIDATION
24271	LINK_EVIDENCE	by 1efd24fe (accepted)
24278	TASK_RESULT	by 1efd24fe (accepted)

Score trace

{
  "claim": "789ceb95-a126-8cb5-a84d-9563192de6e6",
  "links": [
    {
      "kept": "f2e6487e-f77a-8017-98b3-f019d113db42",
      "link": "9df5caa0-7b43-8230-94e4-fadbab61a06f",
      "group": null,
      "reason": "dependent_strongest_only",
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "e5665c75-5156-849c-9515-6ebaeba456bb",
      "direction": "SUPPORT",
      "magnitude": "1.800000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "DIRECT_TEXT",
      "source_type": "PRIMARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "0.000000",
      "interpretive_steps": 0
    },
    {
      "link": "f2e6487e-f77a-8017-98b3-f019d113db42",
      "group": null,
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "1daa2ec6-fc7f-8e36-b18e-aea86c9cf240",
      "direction": "SUPPORT",
      "magnitude": "1.800000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "DIRECT_TEXT",
      "source_type": "PRIMARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "1.800000",
      "interpretive_steps": 0
    }
  ],
  "model": "ledger-default@0.3.0",
  "prior": "0.35",
  "variants": {
    "spread": "0.1933",
    "permissive": "0.8483",
    "conservative": "0.6550"
  },
  "code_hash": "sha256:c61a6fdf35a754a0d7e958df149036a083c0eaeb7d2d2e52704ec32b0c36def7",
  "contested": false,
  "stability": "LOW",
  "claim_type": "CAUSAL",
  "config_hash": "sha256:86768038080b8ab5233f1e4b7aba10af05b5bb44caa432095150b90e81209809",
  "probability": "0.7651",
  "provisional": true,
  "evidence_sum": "1.800000",
  "snapshot_seq": 25252,
  "prior_log_odds": "-0.619039",
  "support_groups": 1,
  "model_dependent": true,
  "review_coverage": "0.25",
  "truth_evaluable": true,
  "assessment_state": "LEANS_SUPPORTED",
  "review_checklist": {
    "qualifiers_reviewed": {
      "by": [],
      "ok": false
    },
    "opposing_search_done": {
      "by": [],
      "ok": false
    },
    "independence_reviewed": {
      "by": [],
      "ok": false
    },
    "primary_source_reviewed": {
      "by": [
        "9df5caa0-7b43-8230-94e4-fadbab61a06f",
        "f2e6487e-f77a-8017-98b3-f019d113db42"
      ],
      "ok": true
    }
  },
  "contradict_groups": 0,
  "rounding_boundary": false,
  "posterior_log_odds": "1.180961",
  "not_applicable_reason": null,
  "independence_unreviewed": 2
}