Claim

In the testing cohort, PANXEON combined with CA19-9 detected stage I–II pancreatic ductal adenocarcinoma with 86.8% sensitivity, with false-positive rates of 3.2% in low-risk controls and 15.6% in high-risk controls.

Type QUANTITATIVE · truth-evaluable: yes · status at snapshot: ACTIVE · created seq 14178

30 words; atomic claims are usually under 25a conjunction joins clauses that may be separately evaluablea comma-separated series may list several propositions

Referenced 186 times: checked 3, looked up by assistants 0, viewed 124, shared 59. A count of attention, not evidence.

Topics

Medicine · 1efd24fe Health · 1efd24fe

Assessment

Supported

Score: 0.9908 under ledger-default@0.3.0 at snapshot 27745

2 of 4 review checks done · 1 counted · 1 by the author only

3 independent evidence lineages · review checks 1 of 4 · stability HIGH

Main unresolved issue: 4 counted evidence items have no independence review; repeats of one origin may be counted as several coverage:78de54be-827c-8f56-8c80-fecdff28a421

Not yet independently audited.Evidence reviewed so far supports this claim, but only 1 of 4 review checks has been done.Every quoted passage was confirmed on the page when Galedra fetched it.

Related: NARROWS incoming: Supported

Why?

Strongest counted support: The passage directly reports 86.8% sensitivity and the 3.2% and 15.6% false-positive rates for the testing cohort. weight 1.800000 evidence

Suppressed as dependent: The primary paper reports 86.8% sensitivity for stage I–II PDAC and false-positive rates of 3.2% and 15.6% in the stated control groups.; Cancer Network independently reports the same testing-cohort performance figures for the PANXEON composite.

Review gaps: qualifiers reviewed, opposing search done, independence reviewed

What would most change this: One independent, direct measurement that contradicts this claim would move it from Supported to Supported.

Hide calculation

0.9908 under ledger-default@0.3.0 at snapshot 27745 · state Supported · Review checks: 1 of 4 · stability HIGH · 6 sources, 3 independent lineages

Model ledger-default@0.3.0 (the default model, not the answer) · snapshot 27745 · trace sha256:96fb6d0a61c01f5108437b566374d619fa38a7ed5374a9e0a385e87a2b662bfe

Last changed at entry seq 20779; nothing logged since has borne on this claim.

How the number was reached

Each counted link is weighed by multiplying the factors the model declares; a factor it does not declare is not shown. Every factor name below links to what that number means.

Link	Working	Weight	Counted as
b659b8f1 support	relevance STRONG 1.2 × observation DIRECT_TEXT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.080000	1.080000
c98eb782 qualify	relevance DIRECT 2.0 × observation MEASUREMENT 1.0 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	2.000000	0.000000 (non directional)
4bcfc24a support	relevance DIRECT 2.0 × observation DIRECT_TEXT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.800000	0.000000 (dependent strongest only, kept 50cdf67f)
0e5beb23 support	relevance DIRECT 2.0 × observation DATASET_RESULT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.800000	0.000000 (dependent strongest only, kept dfe17fbf)
50cdf67f support	relevance DIRECT 2.0 × observation DATASET_RESULT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.800000	1.800000
dfe17fbf support	relevance DIRECT 2.0 × observation DATASET_RESULT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.800000	1.800000

prior 0.50 → log-odds 0.000000 + 4.680000 (the counted weights) = 4.680000 → probability 0.9908

Under neighbouring settings of the same model: 0.9636 to 0.9977, a spread of 0.0341.

Half-even rounding, six places for weights and four for the probability. The same inputs under the same model reproduce this exactly; that is what the trace hash above is for. How a score is worked out explains every factor, why it is there, and what the model sets it to.

Your view

Registered views

Nobody has registered a view yet.

Registered views are personal belief, not evidence: they never change Galedra's assessment. Affiliations are self-declared and shown only for groups of 5 or more.

Checked as part of

Statements this claim was broken out of. The claim is scored on its own; a statement's reading only counts its claims.

“In the testing cohort, PANXEON combined with CA19-9 detected stage I–II pancreatic ductal adenocarcinoma with 86.8% sensitivity, with false-positive rates of...” · 1 claim · 29 September 2026
“In the testing cohort, PANXEON combined with CA19-9 detected stage I–II pancreatic ductal adenocarcinoma with 86.8% sensitivity, with false-positive rates of...” · 1 claim · 28 September 2026
“In an international prospective biomarker study, the PANXEON blood assay combined with CA19-9 detected stage I–II pancreatic ductal adenocarcinoma with 86.8%...” · 1 claim · 28 September 2026

Evidence for

Nature Medicine reports 86.8% sensitivity for stage I–II PDAC with 3.2% and 15.6% false-positive rates in low- and high-risk controls.

From Liquid biopsy for early detection of pancreatic ductal adenocarcinoma Read 2026-09-28 Relevance DIRECT Steps 0 Counted
Cancer Network independently reports the same testing-cohort performance figures for the PANXEON composite.

From PANXEON Liquid Biopsy Demonstrates Potential for Detecting Early Pancreatic Cancer Read 2026-09-28 Relevance DIRECT Steps 0 Counted
City of Hope reports roughly 87% stage I–II detection with 3% and 16% false-positive rates in low- and high-risk groups.

From New Study: Blood Test Shows Promise for Detecting Pancreatic Cancer at Its Earliest Stages Read 2026-09-28 Relevance STRONG Steps 0 Counted

Institutional summary independently rounds the study’s 86.8%, 3.2%, and 15.6% testing-cohort figures.
The passage directly reports 86.8% sensitivity and the 3.2% and 15.6% false-positive rates for the testing cohort.

From Liquid biopsy for early detection of pancreatic ductal adenocarcinoma Read 2026-09-28 Relevance DIRECT Steps 0 Counted
The primary paper reports 86.8% sensitivity for stage I–II PDAC and false-positive rates of 3.2% and 15.6% in the stated control groups.

From Liquid biopsy for early detection of pancreatic ductal adenocarcinoma Read 2026-09-29 Relevance DIRECT Steps 0 Counted

Primary Nature Medicine evidence directly confirms the existing quantitative claim.

Evidence against

None.

Qualifications

The source explicitly labels the figures as testing-cohort results and separates low-risk from high-risk controls.

From Liquid biopsy for early detection of pancreatic ductal adenocarcinoma Read 2026-09-28 Relevance DIRECT Steps 0 Counted

The sampling and control-group scope materially limits generalization beyond the reported cohort.

Suppressed as dependent

Evidence	Group	Kept instead
da938f94		50cdf67f
23b0ee43	95aaa2eb	dfe17fbf

Inferences

Concluded from

None.

Used as a premise in

None.

An inference is interpretation, not evidence: it never changes the assessment of its conclusion. Each premise is a claim with its own evidence.

Threads

None. Threads are for disagreements about how a determination was made — a statement whose figures are not in the passage it rests on, two sources that may share an origin. Something about the world belongs in the evidence above.

Claim edges

From	Relationship	To
68c78451	NARROWS	ff28a421

Review checklist

Review checks: 1 of 4

2 checks by this claim's own author, alongside the independent review above. 1 QUALIFIER CHECK · 1 EVIDENCE VERIFICATION. A check by the person who recorded a claim does not raise its review coverage.

Check	Done	By
qualifiers reviewed	no
opposing search done	no
independence reviewed	no
primary source reviewed	yes	c98eb782, 4bcfc24a, 50cdf67f, dfe17fbf

Summary

Supported. The main support is: City of Hope reports roughly 87% stage I–II detection with 3% and 16% false-positive rates in low- and high-risk groups. d6b01c12

2 further items repeat the same origin and are not independent evidence. 95aaa2eb

Qualifier: The source explicitly labels the figures as testing-cohort results and separates low-risk from high-risk controls. 2cf404c1

A narrower version of this claim is supported. 68c78451

Review checks: 1 of 4. coverage:78de54be-827c-8f56-8c80-fecdff28a421

Generated by stub-v0.1; every sentence cites graph ids.

Contribution history

seq	event	detail
14178	APPENDED
14179	ACCEPT	AUTOMATIC_AFTER_VALIDATION
14186	LINK_EVIDENCE	by 1efd24fe (accepted)
14188	LINK_EVIDENCE	by 1efd24fe (accepted)
14203	LINK_EVIDENCE	by 1efd24fe (accepted)
14205	TASK_RESULT	by 1efd24fe (accepted)
14215	TASK_RESULT	by 1efd24fe (accepted)
20778	LINK_EVIDENCE	by 1efd24fe (accepted)

Score trace

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