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Claim

Cryo-electron microscopy reportedly resolved DILT fibrils at 2.9–4.0 Å, with a repeating unit of 12 peptide chains and C6 symmetry.

Type QUANTITATIVE · truth-evaluable: yes · status at snapshot: ACTIVE · created seq 23815 · qualifiers {"denominator":"Reported cryo-EM structures of DILT fibrils"}

Referenced 141 times: checked 1, looked up by assistants 0, viewed 102, shared 38. A count of attention, not evidence.

Topics

Chemistry · 1efd24fe

Assessment

Supported

Score: 0.8808 under ledger-default@0.3.0 at snapshot 27745

3 of 4 review checks done · 1 counted · 2 by the author only

1 independent evidence lineage · review checks 1 of 4 · stability MEDIUM

Main unresolved issue: 3 counted evidence items have no independence review; repeats of one origin may be counted as several coverage:84cd1e46-948d-8064-a2a8-fa9f4b481b79

Not yet independently audited.Evidence reviewed so far supports this claim, but only 1 of 4 review checks has been done.A quoted passage from tldrdailynews.com was not found on the page when Galedra fetched it.

Why?

Strongest counted support: The report gives 2.9–4.0 Å cryo-EM resolution and a 12-chain C6-symmetric repeating unit. weight 2.000000 evidence

Suppressed as dependent: The excerpt directly reports 2.9–4.0 Å cryo-EM resolution, a 12-chain repeating unit, and C6 symmetry for DILT fibrils.

Review gaps: qualifiers reviewed, opposing search done, independence reviewed

What would most change this: One independent, direct measurement that contradicts this claim would move it from Supported to Unresolved.

Hide calculation

0.8808 under ledger-default@0.3.0 at snapshot 27745 · state Supported · Review checks: 1 of 4 · stability MEDIUM · 3 sources, 1 independent lineage

Model ledger-default@0.3.0 (the default model, not the answer) · snapshot 27745 · trace sha256:b1121c6b7288b4c0b639afd5bdc0779d38ca05992dd7d64c1c26eff88ecdaabb

Last changed at entry seq 26010; nothing logged since has borne on this claim.

How the number was reached

Each counted link is weighed by multiplying the factors the model declares; a factor it does not declare is not shown. Every factor name below links to what that number means.

LinkWorkingWeightCounted as
99f45a8b qualify relevance DIRECT 2.0 × observation DIRECT_TEXT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1 1.800000 0.000000 (non directional)
0885fc90 support relevance DIRECT 2.0 × observation DIRECT_TEXT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1 1.800000 0.000000 (dependent strongest only, kept 7d9b7dec)
7d9b7dec support relevance DIRECT 2.0 × observation MEASUREMENT 1.0 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1 2.000000 2.000000

prior 0.50 → log-odds 0.000000 + 2.000000 (the counted weights) = 2.000000 → probability 0.8808

Under neighbouring settings of the same model: 0.8022 to 0.9309, a spread of 0.1287.

Half-even rounding, six places for weights and four for the probability. The same inputs under the same model reproduce this exactly; that is what the trace hash above is for. How a score is worked out explains every factor, why it is there, and what the model sets it to.

Your view

Sign in to register whether you agree or disagree. A view is yours alone and never changes the assessment.

Registered views

Nobody has registered a view yet.

Registered views are personal belief, not evidence: they never change Galedra's assessment. Affiliations are self-declared and shown only for groups of 5 or more.

Checked as part of

Statements this claim was broken out of. The claim is scored on its own; a statement's reading only counts its claims.

Evidence for

Evidence against

None.

Qualifications

Suppressed as dependent

EvidenceGroupKept instead
cc00f9547d9b7dec

Inferences

Concluded from

None.

Used as a premise in

None.

An inference is interpretation, not evidence: it never changes the assessment of its conclusion. Each premise is a claim with its own evidence.

Threads

None. Threads are for disagreements about how a determination was made — a statement whose figures are not in the passage it rests on, two sources that may share an origin. Something about the world belongs in the evidence above.

Claim edges

None. Edges are stored and displayed; v0.1 does not propagate probability across them.

Review checklist

Review checks: 1 of 4

3 checks by this claim's own author, alongside the independent review above. 1 OPPOSING EVIDENCE SEARCH · 1 QUALIFIER CHECK · 1 EVIDENCE VERIFICATION. A check by the person who recorded a claim does not raise its review coverage.

CheckDoneBy
qualifiers reviewedno
opposing search doneno
independence reviewedno
primary source reviewedyes99f45a8b

Summary

Supported. The main support is: The report gives 2.9–4.0 Å cryo-EM resolution and a 12-chain C6-symmetric repeating unit. 1f6c20c2

1 further item repeats the same origin and is not independent evidence. cc00f954

Qualifier: The 2.9–4.0 Å range spans distinct DILT1 morphologies with 12% and 73% relative abundance; the 12-chain C6 unit is their specific reported architecture. 5e3d8bf6

A search for evidence in the opposing direction found none. 98f471da

Review checks: 1 of 4. coverage:84cd1e46-948d-8064-a2a8-fa9f4b481b79

Generated by stub-v0.1; every sentence cites graph ids.

Contribution history

seqeventdetail
23815APPENDED
23816ACCEPTAUTOMATIC_AFTER_VALIDATION
23831LINK_EVIDENCEby 1efd24fe (accepted)
24450TASK_RESULTby 1efd24fe (accepted)
25302TASK_RESULTby 1efd24fe (accepted)

Score trace

{
  "claim": "84cd1e46-948d-8064-a2a8-fa9f4b481b79",
  "links": [
    {
      "link": "b13f7b78-2c78-8a11-9628-b4e399f45a8b",
      "group": null,
      "reason": "non_directional",
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "b9c8e64e-3564-8975-8b71-43115e3d8bf6",
      "direction": "QUALIFY",
      "magnitude": "1.800000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "DIRECT_TEXT",
      "source_type": "PRIMARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "0.000000",
      "interpretive_steps": 0
    },
    {
      "kept": "d664de70-d058-8abe-9742-fa127d9b7dec",
      "link": "c211d1fe-c007-86a8-85ed-7e840885fc90",
      "group": null,
      "reason": "dependent_strongest_only",
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "4884a1f2-f6d5-8bd9-b096-cac3cc00f954",
      "direction": "SUPPORT",
      "magnitude": "1.800000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "DIRECT_TEXT",
      "source_type": "SECONDARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "0.000000",
      "interpretive_steps": 0
    },
    {
      "link": "d664de70-d058-8abe-9742-fa127d9b7dec",
      "group": null,
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "d4fa47d3-7102-8f92-b3f3-0e8b1f6c20c2",
      "direction": "SUPPORT",
      "magnitude": "2.000000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "MEASUREMENT",
      "source_type": "SECONDARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "2.000000",
      "interpretive_steps": 0
    }
  ],
  "model": "ledger-default@0.3.0",
  "prior": "0.50",
  "variants": {
    "spread": "0.1287",
    "permissive": "0.9309",
    "conservative": "0.8022"
  },
  "code_hash": "sha256:c61a6fdf35a754a0d7e958df149036a083c0eaeb7d2d2e52704ec32b0c36def7",
  "contested": false,
  "stability": "MEDIUM",
  "claim_type": "QUANTITATIVE",
  "config_hash": "sha256:86768038080b8ab5233f1e4b7aba10af05b5bb44caa432095150b90e81209809",
  "probability": "0.8808",
  "provisional": true,
  "evidence_sum": "2.000000",
  "snapshot_seq": 26010,
  "prior_log_odds": "0.000000",
  "support_groups": 1,
  "model_dependent": false,
  "review_coverage": "0.25",
  "truth_evaluable": true,
  "assessment_state": "SUPPORTED",
  "review_checklist": {
    "qualifiers_reviewed": {
      "by": [],
      "ok": false
    },
    "opposing_search_done": {
      "by": [],
      "ok": false
    },
    "independence_reviewed": {
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      "ok": false
    },
    "primary_source_reviewed": {
      "by": [
        "b13f7b78-2c78-8a11-9628-b4e399f45a8b"
      ],
      "ok": true
    }
  },
  "contradict_groups": 0,
  "rounding_boundary": false,
  "posterior_log_odds": "2.000000",
  "not_applicable_reason": null,
  "independence_unreviewed": 3
}