Claim

In mouse heart-attack models, blocking succinate dehydrogenase specifically in cardiomyocytes produced a transient proliferation increase that was insufficient by itself to improve heart function.

Type OBSERVATIONAL · truth-evaluable: yes · status at snapshot: ACTIVE · created seq 20263 · qualifiers {"population":"mouse heart-attack models and cardiomyocytes","intervention":"cardiomyocyte-specific succinate dehydrogenase blockade"}

Referenced 106 times: checked 2, looked up by assistants 0, viewed 70, shared 34. A count of attention, not evidence.

Topics

Medicine · 1efd24fe Health · 1efd24fe

Assessment

Supported

Score: 0.9734 under ledger-default@0.3.0 at snapshot 27745

3 of 4 review checks done · 1 counted · 2 by the author only

2 independent evidence lineages · review checks 1 of 4 · stability HIGH

Main unresolved issue: 3 counted evidence items have no independence review; repeats of one origin may be counted as several coverage:968de05e-0a9a-85ec-9c3a-2edac38cccde

Not yet independently audited.Evidence reviewed so far supports this claim, but only 1 of 4 review checks has been done.Every quoted passage was confirmed on the page when Galedra fetched it.

Why?

Strongest counted support: The primary paper reports transient cardiomyocyte proliferation without improved post-infarction function after cardiomyocyte-specific Sdhb deletion. weight 1.800000 evidence

Suppressed as dependent: The packet directly reports transient cardiomyocyte proliferation that did not by itself improve cardiac function.

Review gaps: qualifiers reviewed, opposing search done, independence reviewed

What would most change this: One independent, direct measurement that contradicts this claim would move it from Supported to Supported.

Hide calculation

0.9734 under ledger-default@0.3.0 at snapshot 27745 · state Supported · Review checks: 1 of 4 · stability HIGH · 3 sources, 2 independent lineages

Model ledger-default@0.3.0 (the default model, not the answer) · snapshot 27745 · trace sha256:46d0e6077cc86535362cfa39f131d3a25d09e804530192a39dbaed6054749059

Last changed at entry seq 25882; nothing logged since has borne on this claim.

How the number was reached

Each counted link is weighed by multiplying the factors the model declares; a factor it does not declare is not shown. Every factor name below links to what that number means.

Link	Working	Weight	Counted as
9b3f4d75 support	relevance DIRECT 2.0 × observation DIRECT_TEXT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.800000	1.800000
8462fa58 support	relevance DIRECT 2.0 × observation DIRECT_TEXT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.800000	0.000000 (dependent strongest only, kept 5dd36879)
5dd36879 support	relevance DIRECT 2.0 × observation DIRECT_TEXT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.800000	1.800000

prior 0.50 → log-odds 0.000000 + 3.600000 (the counted weights) = 3.600000 → probability 0.9734

Under neighbouring settings of the same model: 0.9255 to 0.9908, a spread of 0.0653.

Half-even rounding, six places for weights and four for the probability. The same inputs under the same model reproduce this exactly; that is what the trace hash above is for. How a score is worked out explains every factor, why it is there, and what the model sets it to.

Your view

Registered views

Nobody has registered a view yet.

Registered views are personal belief, not evidence: they never change Galedra's assessment. Affiliations are self-declared and shown only for groups of 5 or more.

Checked as part of

Statements this claim was broken out of. The claim is scored on its own; a statement's reading only counts its claims.

“In mouse heart-attack models, blocking succinate dehydrogenase specifically in cardiomyocytes produced a transient proliferation increase that was...” · 1 claim · 29 September 2026
“In mouse heart-attack models, blocking succinate dehydrogenase in cardiac fibroblasts suppressed fibroblast activation and reduced scar formation, improving...” · 2 claims · 29 September 2026

Evidence for

The report says cardiomyocyte-specific blockade increased proliferation transiently but did not by itself improve function.

From Modifying Heart Cell Metabolism Unlocks Self-Repair System After Heart Attack Read 2026-09-29 Relevance DIRECT Steps 0 Counted
The packet directly reports transient cardiomyocyte proliferation that did not by itself improve cardiac function.

From Modifying Heart Cell Metabolism Unlocks Self-Repair System After Heart Attack Read 2026-09-29 Relevance DIRECT Steps 0 Counted
The primary paper reports transient cardiomyocyte proliferation without improved post-infarction function after cardiomyocyte-specific Sdhb deletion.

From A metabolic–epigenetic switch governs multicellular cardiac repair following succinate dehydrogenase inhibition Read 2026-09-29 Relevance DIRECT Steps 0 Counted

Independent primary article evidence directly matches the claim previously recorded from a study report.

Evidence against

None.

Qualifications

None.

Suppressed as dependent

Evidence	Group	Kept instead
8bc282e4		5dd36879

Inferences

Concluded from

None.

Used as a premise in

None.

An inference is interpretation, not evidence: it never changes the assessment of its conclusion. Each premise is a claim with its own evidence.

Threads

None. Threads are for disagreements about how a determination was made — a statement whose figures are not in the passage it rests on, two sources that may share an origin. Something about the world belongs in the evidence above.

Claim edges

None. Edges are stored and displayed; v0.1 does not propagate probability across them.

Review checklist

Review checks: 1 of 4

3 checks by this claim's own author, alongside the independent review above. 1 OPPOSING EVIDENCE SEARCH · 1 QUALIFIER CHECK · 1 EVIDENCE VERIFICATION. A check by the person who recorded a claim does not raise its review coverage.

Check	Done	By
qualifiers reviewed	no
opposing search done	no
independence reviewed	no
primary source reviewed	yes	9b3f4d75

Summary

Supported. The main support is: The primary paper reports transient cardiomyocyte proliferation without improved post-infarction function after cardiomyocyte-specific Sdhb deletion. 6419587a

1 further item repeats the same origin and is not independent evidence. 8bc282e4

A search for evidence in the opposing direction found none. 2e0ce8e0

Review checks: 1 of 4. coverage:968de05e-0a9a-85ec-9c3a-2edac38cccde

Generated by stub-v0.1; every sentence cites graph ids.

Contribution history

seq	event	detail
20263	APPENDED
20264	ACCEPT	AUTOMATIC_AFTER_VALIDATION
20273	LINK_EVIDENCE	by 1efd24fe (accepted)
20277	TASK_RESULT	by 1efd24fe (accepted)
20285	LINK_EVIDENCE	by 1efd24fe (accepted)

Score trace

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  "claim": "968de05e-0a9a-85ec-9c3a-2edac38cccde",
  "links": [
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      "link": "0ffcf970-9083-8de7-ba14-82db9b3f4d75",
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      "audit_confirmed": false,
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      "group": null,
      "reason": "dependent_strongest_only",
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      "audit_confirmed": false,
      "effective_weight": "0.000000",
      "interpretive_steps": 0
    },
    {
      "link": "bfa6758a-3d6f-82d6-be75-4b935dd36879",
      "group": null,
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "e145f8cd-69b0-801f-9f1c-622e16fe731b",
      "direction": "SUPPORT",
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      "audit_confirmed": false,
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      "interpretive_steps": 0
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  ],
  "model": "ledger-default@0.3.0",
  "prior": "0.50",
  "variants": {
    "spread": "0.0653",
    "permissive": "0.9908",
    "conservative": "0.9255"
  },
  "code_hash": "sha256:c61a6fdf35a754a0d7e958df149036a083c0eaeb7d2d2e52704ec32b0c36def7",
  "contested": false,
  "stability": "HIGH",
  "claim_type": "OBSERVATIONAL",
  "config_hash": "sha256:86768038080b8ab5233f1e4b7aba10af05b5bb44caa432095150b90e81209809",
  "probability": "0.9734",
  "provisional": true,
  "evidence_sum": "3.600000",
  "snapshot_seq": 25882,
  "prior_log_odds": "0.000000",
  "support_groups": 2,
  "model_dependent": false,
  "review_coverage": "0.25",
  "truth_evaluable": true,
  "assessment_state": "SUPPORTED",
  "review_checklist": {
    "qualifiers_reviewed": {
      "by": [],
      "ok": false
    },
    "opposing_search_done": {
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      "ok": false
    },
    "independence_reviewed": {
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      "ok": false
    },
    "primary_source_reviewed": {
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      ],
      "ok": true
    }
  },
  "contradict_groups": 0,
  "rounding_boundary": false,
  "posterior_log_odds": "3.600000",
  "not_applicable_reason": null,
  "independence_unreviewed": 3
}