Claim

The combinatorial relationships among regulatory motifs were largely species-specific, and models trained on individual cell types within a family lost cross-species predictive power, indicating rapidly evolving cell-type regulatory syntax.

Type COMPARATIVE · truth-evaluable: yes · status at snapshot: ACTIVE · created seq 20741 · qualifiers {"scope":"Comparative single-nucleus multi-omic and deep-learning study of flatworms and vertebrates."}

29 words; atomic claims are usually under 25a conjunction joins clauses that may be separately evaluablea comma-separated series may list several propositions

Referenced 104 times: checked 2, looked up by assistants 0, viewed 64, shared 38. A count of attention, not evidence.

Topics

Biology · 1efd24fe Science · 1efd24fe

Assessment

Supported

Score: 0.9955 under ledger-default@0.3.0 at snapshot 27745

3 of 4 review checks done · 1 counted · 2 by the author only

3 independent evidence lineages · review checks 1 of 4 · stability HIGH

Main unresolved issue: 4 counted evidence items have no independence review; repeats of one origin may be counted as several coverage:9fb8e39d-4850-8396-9d53-ac75d4a13ee9

Not yet independently audited.Evidence reviewed so far supports this claim, but only 1 of 4 review checks has been done.A quoted passage from scienmag.com was not found on the page when Galedra fetched it.

Why?

Strongest counted support: The excerpt directly reports species-specific motif combinations and loss of cell-type-level cross-species predictive power. weight 1.800000 evidence

Suppressed as dependent: The abstract directly reports species-specific motif combinations and loss of cell-type-level cross-species predictive power.

Review gaps: qualifiers reviewed, opposing search done, independence reviewed

What would most change this: One independent, direct measurement that contradicts this claim would move it from Supported to Supported.

Hide calculation

0.9955 under ledger-default@0.3.0 at snapshot 27745 · state Supported · Review checks: 1 of 4 · stability HIGH · 4 sources, 3 independent lineages

Model ledger-default@0.3.0 (the default model, not the answer) · snapshot 27745 · trace sha256:d4179dca15be0dab745bde3e9b53dd496bad444f5af22493ae77e88207a95f72

Last changed at entry seq 24342; nothing logged since has borne on this claim.

How the number was reached

Each counted link is weighed by multiplying the factors the model declares; a factor it does not declare is not shown. Every factor name below links to what that number means.

Link	Working	Weight	Counted as
c96b2b32 support	relevance DIRECT 2.0 × observation MODEL_OUTPUT 0.0 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	0.000000	0.000000 (dependent strongest only, kept d2b421ed)
d2b421ed support	relevance DIRECT 2.0 × observation DIRECT_TEXT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.800000	1.800000
a722960f support	relevance DIRECT 2.0 × observation DIRECT_TEXT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.800000	1.800000
b5c84a0f support	relevance DIRECT 2.0 × observation DIRECT_TEXT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.800000	1.800000

prior 0.50 → log-odds 0.000000 + 5.400000 (the counted weights) = 5.400000 → probability 0.9955

Under neighbouring settings of the same model: 0.9777 to 0.9991, a spread of 0.0214.

Half-even rounding, six places for weights and four for the probability. The same inputs under the same model reproduce this exactly; that is what the trace hash above is for. How a score is worked out explains every factor, why it is there, and what the model sets it to.

Your view

Registered views

Nobody has registered a view yet.

Registered views are personal belief, not evidence: they never change Galedra's assessment. Affiliations are self-declared and shown only for groups of 5 or more.

Checked as part of

Statements this claim was broken out of. The claim is scored on its own; a statement's reading only counts its claims.

“The combinatorial relationships among regulatory motifs were largely species-specific, and models trained on individual cell types within a family lost...” · 1 claim · 29 September 2026
“A comparative single-nucleus multi-omic and deep-learning study of flatworms and vertebrates found that regulatory sequence motifs form conserved...” · 2 claims · 29 September 2026

Evidence for

The abstract directly reports species-specific motif combinations and loss of cell-type-level cross-species predictive power.

From Flexible use of conserved motifs constrains genome access in cell type evolution Read 2026-09-29 Relevance DIRECT Steps 0 Counted
A secondary report corroborates rapid evolution of individual cell-type regulatory programmes alongside collective conservation of family-level identity.

From Ancient DNA Word Vocabularies Govern How Cell Types Evolve Across Species Read 2026-09-29 Relevance DIRECT Steps 0 Counted
The excerpt directly reports species-specific motif combinations and loss of cell-type-level cross-species predictive power.

From Flexible use of conserved motifs constrains genome access in cell type evolution Read 2026-09-29 Relevance DIRECT Steps 0 Counted

The packet explicitly states both species-specific combinatorial relationships and loss of cross-species prediction for individual cell types.
The abstract reports largely species-specific motif combinations and loss of cross-species predictive power for models trained on individual cell types within a family, indicating rapidly evolving cell-type regulatory syntax.

From Flexible use of conserved motifs constrains genome access in cell type evolution Read 2026-09-29 Relevance DIRECT Steps 0 Counted

Evidence against

None.

Qualifications

None.

Suppressed as dependent

Evidence	Group	Kept instead
36324e59		d2b421ed

Inferences

Concluded from

None.

Used as a premise in

None.

An inference is interpretation, not evidence: it never changes the assessment of its conclusion. Each premise is a claim with its own evidence.

Threads

None. Threads are for disagreements about how a determination was made — a statement whose figures are not in the passage it rests on, two sources that may share an origin. Something about the world belongs in the evidence above.

Claim edges

None. Edges are stored and displayed; v0.1 does not propagate probability across them.

Review checklist

Review checks: 1 of 4

3 checks by this claim's own author, alongside the independent review above. 1 OPPOSING EVIDENCE SEARCH · 1 QUALIFIER CHECK · 1 EVIDENCE VERIFICATION. A check by the person who recorded a claim does not raise its review coverage.

Check	Done	By
qualifiers reviewed	no
opposing search done	no
independence reviewed	no
primary source reviewed	yes	c96b2b32, d2b421ed, a722960f

Summary

Supported. The main support is: The excerpt directly reports species-specific motif combinations and loss of cell-type-level cross-species predictive power. 95dbd478

1 further item repeats the same origin and is not independent evidence. 36324e59

A search for evidence in the opposing direction found something; see the counted evidence. 2b0bf810

Review checks: 1 of 4. coverage:9fb8e39d-4850-8396-9d53-ac75d4a13ee9

Generated by stub-v0.1; every sentence cites graph ids.

Contribution history

seq	event	detail
20741	APPENDED
20742	ACCEPT	AUTOMATIC_AFTER_VALIDATION
20751	LINK_EVIDENCE	by 1efd24fe (accepted)
20759	LINK_EVIDENCE	by 1efd24fe (accepted)
22064	TASK_RESULT	by 1efd24fe (accepted)
24341	TASK_RESULT	by 1efd24fe (accepted)

Score trace

{
  "claim": "9fb8e39d-4850-8396-9d53-ac75d4a13ee9",
  "links": [
    {
      "kept": "5fba7b5a-314a-840a-b87a-c6f6d2b421ed",
      "link": "0d686aa5-0251-85c2-b1e4-47d1c96b2b32",
      "group": null,
      "reason": "dependent_strongest_only",
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "e81ee4c3-1a8d-893f-8cbc-462e36324e59",
      "direction": "SUPPORT",
      "magnitude": "0.000000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "MODEL_OUTPUT",
      "source_type": "PRIMARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "0.000000",
      "interpretive_steps": 0
    },
    {
      "link": "5fba7b5a-314a-840a-b87a-c6f6d2b421ed",
      "group": null,
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "a1b9a4bd-f888-8275-8edb-f6ba95dbd478",
      "direction": "SUPPORT",
      "magnitude": "1.800000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "DIRECT_TEXT",
      "source_type": "PRIMARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "1.800000",
      "interpretive_steps": 0
    },
    {
      "link": "81c3192a-be41-84ec-bea0-7944a722960f",
      "group": null,
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "b05ff585-d918-85d7-b975-a1c95f945f5e",
      "direction": "SUPPORT",
      "magnitude": "1.800000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "DIRECT_TEXT",
      "source_type": "PRIMARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "1.800000",
      "interpretive_steps": 0
    },
    {
      "link": "82927a6c-f5f7-8e47-bec2-ab53b5c84a0f",
      "group": null,
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "afb662dc-e795-8c1a-9e96-7959dc75cbb5",
      "direction": "SUPPORT",
      "magnitude": "1.800000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "DIRECT_TEXT",
      "source_type": "SECONDARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "1.800000",
      "interpretive_steps": 0
    }
  ],
  "model": "ledger-default@0.3.0",
  "prior": "0.50",
  "variants": {
    "spread": "0.0214",
    "permissive": "0.9991",
    "conservative": "0.9777"
  },
  "code_hash": "sha256:c61a6fdf35a754a0d7e958df149036a083c0eaeb7d2d2e52704ec32b0c36def7",
  "contested": false,
  "stability": "HIGH",
  "claim_type": "COMPARATIVE",
  "config_hash": "sha256:86768038080b8ab5233f1e4b7aba10af05b5bb44caa432095150b90e81209809",
  "probability": "0.9955",
  "provisional": true,
  "evidence_sum": "5.400000",
  "snapshot_seq": 24342,
  "prior_log_odds": "0.000000",
  "support_groups": 3,
  "model_dependent": false,
  "review_coverage": "0.25",
  "truth_evaluable": true,
  "assessment_state": "SUPPORTED",
  "review_checklist": {
    "qualifiers_reviewed": {
      "by": [],
      "ok": false
    },
    "opposing_search_done": {
      "by": [],
      "ok": false
    },
    "independence_reviewed": {
      "by": [],
      "ok": false
    },
    "primary_source_reviewed": {
      "by": [
        "0d686aa5-0251-85c2-b1e4-47d1c96b2b32",
        "5fba7b5a-314a-840a-b87a-c6f6d2b421ed",
        "81c3192a-be41-84ec-bea0-7944a722960f"
      ],
      "ok": true
    }
  },
  "contradict_groups": 0,
  "rounding_boundary": false,
  "posterior_log_odds": "5.400000",
  "not_applicable_reason": null,
  "independence_unreviewed": 4
}