Claim

Model ledger-default@0.1.0 ledger-strict@0.1.0 ledger-default@0.2.0 ledger-strict@0.2.0 ledger-default@0.3.0 (default) ledger-strict@0.3.0 Snapshot seq

Topics

Biology · 1efd24fe Science · 1efd24fe

Assessment

Why?

Strongest counted support: The excerpt directly reports species-specific motif combinations and loss of cell-type-level cross-species predictive power. weight 1.800000 evidence

Suppressed as dependent: The abstract directly reports species-specific motif combinations and loss of cell-type-level cross-species predictive power.

Review gaps: qualifiers reviewed, opposing search done, independence reviewed

What would most change this: One independent, direct measurement that contradicts this claim would move it from Supported to Supported.

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Checked as part of

Statements this claim was broken out of. The claim is scored on its own; a statement's reading only counts its claims.

• “The combinatorial relationships among regulatory motifs were largely species-specific, and models trained on individual cell types within a family lost...” · 1 claim · 29 September 2026
• “A comparative single-nucleus multi-omic and deep-learning study of flatworms and vertebrates found that regulatory sequence motifs form conserved...” · 2 claims · 29 September 2026

Evidence for

• The abstract directly reports species-specific motif combinations and loss of cell-type-level cross-species predictive power.

  From Flexible use of conserved motifs constrains genome access in cell type evolution Read 2026-09-29 Relevance DIRECT Steps 0 Counted

• A secondary report corroborates rapid evolution of individual cell-type regulatory programmes alongside collective conservation of family-level identity.

  From Ancient DNA Word Vocabularies Govern How Cell Types Evolve Across Species Read 2026-09-29 Relevance DIRECT Steps 0 Counted

• The excerpt directly reports species-specific motif combinations and loss of cell-type-level cross-species predictive power.

  From Flexible use of conserved motifs constrains genome access in cell type evolution Read 2026-09-29 Relevance DIRECT Steps 0 Counted

  The packet explicitly states both species-specific combinatorial relationships and loss of cross-species prediction for individual cell types.

• The abstract reports largely species-specific motif combinations and loss of cross-species predictive power for models trained on individual cell types within a family, indicating rapidly evolving cell-type regulatory syntax.

  From Flexible use of conserved motifs constrains genome access in cell type evolution Read 2026-09-29 Relevance DIRECT Steps 0 Counted

Evidence against

None.

Qualifications

None.

Suppressed as dependent

Evidence	Group	Kept instead
36324e59		d2b421ed

Inferences

Concluded from

None.

Used as a premise in

None.

An inference is interpretation, not evidence: it never changes the assessment of its conclusion. Each premise is a claim with its own evidence.

Threads

None. Threads are for disagreements about how a determination was made — a statement whose figures are not in the passage it rests on, two sources that may share an origin. Something about the world belongs in the evidence above.

Claim edges

None. Edges are stored and displayed; v0.1 does not propagate probability across them.

Review checklist

Review checks: 1 of 4

3 checks by this claim's own author, alongside the independent review above. 1 OPPOSING EVIDENCE SEARCH · 1 QUALIFIER CHECK · 1 EVIDENCE VERIFICATION. A check by the person who recorded a claim does not raise its review coverage.

Check	Done	By
qualifiers reviewed	no
opposing search done	no
independence reviewed	no
primary source reviewed	yes	c96b2b32, d2b421ed, a722960f

Summary

Contribution history

seq	event	detail
20741	APPENDED
20742	ACCEPT	AUTOMATIC_AFTER_VALIDATION
20751	LINK_EVIDENCE	by 1efd24fe (accepted)
20759	LINK_EVIDENCE	by 1efd24fe (accepted)
22064	TASK_RESULT	by 1efd24fe (accepted)
24341	TASK_RESULT	by 1efd24fe (accepted)