Claim

Model ledger-default@0.1.0 ledger-strict@0.1.0 ledger-default@0.2.0 ledger-strict@0.2.0 ledger-default@0.3.0 (default) ledger-strict@0.3.0 Snapshot seq

Topics

Biology · 1efd24fe AI · 1efd24fe

Assessment

Why?

Strongest counted support: The main text reports higher rare-variant enrichment than comparator conservation scores across all five non-human species. weight 1.800000 evidence

Suppressed as dependent: The excerpt directly states GPN-Star was trained for five named non-human model organisms to demonstrate robustness and generalizability.

Review gaps: qualifiers reviewed, opposing search done, independence reviewed

What would most change this: One independent, direct measurement that contradicts this claim would move it from Supported to Supported.

Hide calculation

Your view

Registered views

Checked as part of

Statements this claim was broken out of. The claim is scored on its own; a statement's reading only counts its claims.

• “The study trained GPN-Star for five model organisms beyond humans, demonstrating robustness and generalizability across those species.” · 1 claim · 29 September 2026
• “The Nature study introduced GPN-Star, a phylogeny-aware genomic language model for predicting genome-wide functional constraints and variant effects.” · 3 claims · 29 September 2026

Evidence for

• The primary abstract reports training on five named non-human model organisms as a generalizability demonstration.

  From Predicting genome-wide functional constraints with GPN-Star Read 2026-09-29 Relevance DIRECT Steps 0 Counted

  Exact abstract generalizability statement.

• The main text reports higher rare-variant enrichment than comparator conservation scores across all five non-human species.

  From Predicting genome-wide functional constraints with GPN-Star Read 2026-09-29 Relevance DIRECT Steps 0 Counted

  Specific primary-text cross-species evaluation.

• The excerpt directly states GPN-Star was trained for five named non-human model organisms to demonstrate robustness and generalizability.

  From Predicting genome-wide functional constraints with GPN-Star Read 2026-09-29 Relevance DIRECT Steps 0 Counted

Evidence against

None.

Qualifications

• The generalizability demonstration covers five named model organisms using species-specific alignments of 18–135 species and adjusted training procedures, not all taxa.

  From Predicting genome-wide functional constraints with GPN-Star Read 2026-09-29 Relevance DIRECT Steps 0 Counted

  Adds organism denominator, comparative-genomics sample range, and species-specific training-adjustment limits.

Suppressed as dependent

Evidence	Group	Kept instead
b1aec8f6		8308a54a

Inferences

Concluded from

None.

Used as a premise in

None.

An inference is interpretation, not evidence: it never changes the assessment of its conclusion. Each premise is a claim with its own evidence.

Threads

None. Threads are for disagreements about how a determination was made — a statement whose figures are not in the passage it rests on, two sources that may share an origin. Something about the world belongs in the evidence above.

Claim edges

None. Edges are stored and displayed; v0.1 does not propagate probability across them.

Review checklist

Review checks: 1 of 4

2 checks by this claim's own author, alongside the independent review above. 1 QUALIFIER CHECK · 1 EVIDENCE VERIFICATION. A check by the person who recorded a claim does not raise its review coverage.

Check	Done	By
qualifiers reviewed	no
opposing search done	no
independence reviewed	no
primary source reviewed	yes	2c45e3a8, 1722fa53, b07fc284, 8308a54a

Summary

Contribution history

seq	event	detail
22389	APPENDED
22390	ACCEPT	AUTOMATIC_AFTER_VALIDATION
22403	LINK_EVIDENCE	by 1efd24fe (accepted)
22453	LINK_EVIDENCE	by 1efd24fe (accepted)
24593	TASK_RESULT	by 1efd24fe (accepted)
25652	TASK_RESULT	by 1efd24fe (accepted)

Score trace

{
  "claim": "25653751-6aac-87ad-9882-9cea8f03848d",
  "links": [
    {
      "link": "34e15730-b967-8fa1-8a8b-52852c45e3a8",
      "group": null,
      "reason": "non_directional",
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "372a7047-b188-8de3-9290-b23ffa19c451",
      "direction": "QUALIFY",
      "magnitude": "0.000000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "MODEL_OUTPUT",
      "source_type": "PRIMARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "0.000000",
      "interpretive_steps": 0
    },
    {
      "kept": "a8a03c96-319d-8199-a75a-b5718308a54a",
      "link": "38852b48-555e-85ab-91e1-7bab1722fa53",
      "group": null,
      "reason": "dependent_strongest_only",
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "4c6aad83-78d5-8345-9610-2b22b1aec8f6",
      "direction": "SUPPORT",
      "magnitude": "1.800000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "DIRECT_TEXT",
      "source_type": "PRIMARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "0.000000",
      "interpretive_steps": 0
    },
    {
      "link": "3fb491cf-1049-8580-8689-c576b07fc284",
      "group": null,
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "ec79734f-2fe6-81eb-9abd-fa1522673b1b",
      "direction": "SUPPORT",
      "magnitude": "1.800000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "DIRECT_TEXT",
      "source_type": "PRIMARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "1.800000",
      "interpretive_steps": 0
    },
    {
      "link": "a8a03c96-319d-8199-a75a-b5718308a54a",
      "group": null,
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "41ac3c0e-bc07-84b3-802a-ff8ace89fdad",
      "direction": "SUPPORT",
      "magnitude": "1.800000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "DIRECT_TEXT",
      "source_type": "PRIMARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "1.800000",
      "interpretive_steps": 0
    }
  ],
  "model": "ledger-default@0.3.0",
  "prior": "0.50",
  "variants": {
    "spread": "0.0653",
    "permissive": "0.9908",
    "conservative": "0.9255"
  },
  "code_hash": "sha256:c61a6fdf35a754a0d7e958df149036a083c0eaeb7d2d2e52704ec32b0c36def7",
  "contested": false,
  "stability": "HIGH",
  "claim_type": "OBSERVATIONAL",
  "config_hash": "sha256:86768038080b8ab5233f1e4b7aba10af05b5bb44caa432095150b90e81209809",
  "probability": "0.9734",
  "provisional": true,
  "evidence_sum": "3.600000",
  "snapshot_seq": 25653,
  "prior_log_odds": "0.000000",
  "support_groups": 2,
  "model_dependent": false,
  "review_coverage": "0.25",
  "truth_evaluable": true,
  "assessment_state": "SUPPORTED",
  "review_checklist": {
    "qualifiers_reviewed": {
      "by": [],
      "ok": false
    },
    "opposing_search_done": {
      "by": [],
      "ok": false
    },
    "independence_reviewed": {
      "by": [],
      "ok": false
    },
    "primary_source_reviewed": {
      "by": [
        "34e15730-b967-8fa1-8a8b-52852c45e3a8",
        "38852b48-555e-85ab-91e1-7bab1722fa53",
        "3fb491cf-1049-8580-8689-c576b07fc284",
        "a8a03c96-319d-8199-a75a-b5718308a54a"
      ],
      "ok": true
    }
  },
  "contradict_groups": 0,
  "rounding_boundary": false,
  "posterior_log_odds": "3.600000",
  "not_applicable_reason": null,
  "independence_unreviewed": 4
}