Claim

In the study, deleting RANKL in lymphoid tissue organizer cells caused an almost complete absence of Thetis-cell subset TC I.

Type CAUSAL · truth-evaluable: yes · status at snapshot: ACTIVE · created seq 21532

Referenced 121 times: checked 2, looked up by assistants 0, viewed 77, shared 42. A count of attention, not evidence.

Topics

Biology · 1efd24fe Health · 1efd24fe

Assessment

Leans supported

Score: 0.7991 under ledger-default@0.3.0 at snapshot 27745

3 of 4 review checks done · 1 counted · 2 by the author only

1 independent evidence lineage · review checks 1 of 4 · stability LOW

Main unresolved issue: 3 counted evidence items have no independence review; repeats of one origin may be counted as several coverage:25b113b7-5291-8c83-ae78-4c9356873231

Not yet independently audited.This assessment depends heavily on modeling choices.A quoted passage from nature.com was not found on the page when Galedra fetched it.

Why?

Strongest counted support: The primary study reports selective loss of TC I after RANKL deletion in organizer cells. weight 2.000000 evidence

Suppressed as dependent: The primary Nature study reports selective loss of Thetis-cell subset TC I after RANKL deletion in lymphoid tissue organizer cells.; The passage directly states that RANKL ablation in LTo cells led to an almost complete absence of TC I.

Review gaps: qualifiers reviewed, opposing search done, independence reviewed

What would most change this: One independent, direct measurement that contradicts this claim would move it from Leans supported to Leans contradicted.

Hide calculation

0.7991 under ledger-default@0.3.0 at snapshot 27745 · state Leans supported · Review checks: 1 of 4 · stability LOW · 3 sources, 1 independent lineage

Model ledger-default@0.3.0 (the default model, not the answer) · snapshot 27745 · trace sha256:158327941970d2680733bc2e865ea1e019b205ccbd85e009ca01f99c709cade9

Last changed at entry seq 25752; nothing logged since has borne on this claim.

How the number was reached

Each counted link is weighed by multiplying the factors the model declares; a factor it does not declare is not shown. Every factor name below links to what that number means.

Link	Working	Weight	Counted as
913c6e15 support	relevance DIRECT 2.0 × observation MEASUREMENT 1.0 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	2.000000	2.000000
3a48db24 support	relevance DIRECT 2.0 × observation DIRECT_TEXT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.800000	0.000000 (dependent strongest only, kept 913c6e15)
06be1451 support	relevance DIRECT 2.0 × observation DIRECT_TEXT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.800000	0.000000 (dependent strongest only, kept 913c6e15)

prior 0.35 → log-odds -0.619039 + 2.000000 (the counted weights) = 1.380961 → probability 0.7991

Under neighbouring settings of the same model: 0.6859 to 0.8788, a spread of 0.1929.

Half-even rounding, six places for weights and four for the probability. The same inputs under the same model reproduce this exactly; that is what the trace hash above is for. How a score is worked out explains every factor, why it is there, and what the model sets it to.

Your view

Registered views

Nobody has registered a view yet.

Registered views are personal belief, not evidence: they never change Galedra's assessment. Affiliations are self-declared and shown only for groups of 5 or more.

Checked as part of

Statements this claim was broken out of. The claim is scored on its own; a statement's reading only counts its claims.

“In the study, deleting RANKL in lymphoid tissue organizer cells caused an almost complete absence of Thetis-cell subset TC I.” · 1 claim · 29 September 2026
“A primary Nature study mapped Thetis-cell progenitors, lineage origin, and developmental cues in mice.” · 3 claims · 29 September 2026

Evidence for

The primary study reports selective loss of TC I after RANKL deletion in organizer cells.

From Ontogeny and transcriptional regulation of Thetis cells Read 2026-09-29 Relevance DIRECT Steps 0 Counted

Primary developmental perturbation result.
The primary Nature study reports selective loss of Thetis-cell subset TC I after RANKL deletion in lymphoid tissue organizer cells.

From Ontogeny and transcriptional regulation of Thetis cells Read 2026-09-29 Relevance DIRECT Steps 0 Counted

Independent attachment of the exact primary-study result.
The passage directly states that RANKL ablation in LTo cells led to an almost complete absence of TC I.

From Ontogeny and transcriptional regulation of Thetis cells Read 2026-09-29 Relevance DIRECT Steps 0 Counted

Evidence against

None.

Qualifications

None.

Suppressed as dependent

Evidence	Group	Kept instead
d30ef209		913c6e15
ae79a435		913c6e15

Inferences

Concluded from

None.

Used as a premise in

None.

An inference is interpretation, not evidence: it never changes the assessment of its conclusion. Each premise is a claim with its own evidence.

Threads

None. Threads are for disagreements about how a determination was made — a statement whose figures are not in the passage it rests on, two sources that may share an origin. Something about the world belongs in the evidence above.

Claim edges

None. Edges are stored and displayed; v0.1 does not propagate probability across them.

Review checklist

Review checks: 1 of 4

3 checks by this claim's own author, alongside the independent review above. 1 OPPOSING EVIDENCE SEARCH · 1 QUALIFIER CHECK · 1 EVIDENCE VERIFICATION. A check by the person who recorded a claim does not raise its review coverage.

Check	Done	By
qualifiers reviewed	no
opposing search done	no
independence reviewed	no
primary source reviewed	yes	913c6e15, 3a48db24, 06be1451

Summary

Leans supported. The main support is: The primary study reports selective loss of TC I after RANKL deletion in organizer cells. 97071fd7

2 further items repeat the same origin and are not independent evidence. d30ef209ae79a435

A search for evidence in the opposing direction found none. 3df37cd5

Review checks: 1 of 4. coverage:25b113b7-5291-8c83-ae78-4c9356873231

Generated by stub-v0.1; every sentence cites graph ids.

Contribution history

seq	event	detail
21532	APPENDED
21533	ACCEPT	AUTOMATIC_AFTER_VALIDATION
21546	LINK_EVIDENCE	by 1efd24fe (accepted)
21632	LINK_EVIDENCE	by 1efd24fe (accepted)
24119	TASK_RESULT	by 1efd24fe (accepted)

Score trace

{
  "claim": "25b113b7-5291-8c83-ae78-4c9356873231",
  "links": [
    {
      "link": "49b8e142-bd5e-8218-b0e8-d9b2913c6e15",
      "group": null,
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "d31f2531-9021-869c-b84c-8fce97071fd7",
      "direction": "SUPPORT",
      "magnitude": "2.000000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "MEASUREMENT",
      "source_type": "PRIMARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "2.000000",
      "interpretive_steps": 0
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    {
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      "link": "a5768aa1-37f6-812b-98e3-ef1e3a48db24",
      "group": null,
      "reason": "dependent_strongest_only",
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "38cf2462-8b7f-84c2-8866-b8c9d30ef209",
      "direction": "SUPPORT",
      "magnitude": "1.800000",
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      "extraction": "UNVERIFIED",
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      "source_type": "PRIMARY_TEXT",
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      "audit_confirmed": false,
      "effective_weight": "0.000000",
      "interpretive_steps": 0
    },
    {
      "kept": "49b8e142-bd5e-8218-b0e8-d9b2913c6e15",
      "link": "fc5636d9-5981-8713-b300-529b06be1451",
      "group": null,
      "reason": "dependent_strongest_only",
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "ce625d41-933d-8a40-8646-2e15ae79a435",
      "direction": "SUPPORT",
      "magnitude": "1.800000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "DIRECT_TEXT",
      "source_type": "PRIMARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "0.000000",
      "interpretive_steps": 0
    }
  ],
  "model": "ledger-default@0.3.0",
  "prior": "0.35",
  "variants": {
    "spread": "0.1929",
    "permissive": "0.8788",
    "conservative": "0.6859"
  },
  "code_hash": "sha256:c61a6fdf35a754a0d7e958df149036a083c0eaeb7d2d2e52704ec32b0c36def7",
  "contested": false,
  "stability": "LOW",
  "claim_type": "CAUSAL",
  "config_hash": "sha256:86768038080b8ab5233f1e4b7aba10af05b5bb44caa432095150b90e81209809",
  "probability": "0.7991",
  "provisional": true,
  "evidence_sum": "2.000000",
  "snapshot_seq": 25752,
  "prior_log_odds": "-0.619039",
  "support_groups": 1,
  "model_dependent": true,
  "review_coverage": "0.25",
  "truth_evaluable": true,
  "assessment_state": "LEANS_SUPPORTED",
  "review_checklist": {
    "qualifiers_reviewed": {
      "by": [],
      "ok": false
    },
    "opposing_search_done": {
      "by": [],
      "ok": false
    },
    "independence_reviewed": {
      "by": [],
      "ok": false
    },
    "primary_source_reviewed": {
      "by": [
        "49b8e142-bd5e-8218-b0e8-d9b2913c6e15",
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        "fc5636d9-5981-8713-b300-529b06be1451"
      ],
      "ok": true
    }
  },
  "contradict_groups": 0,
  "rounding_boundary": false,
  "posterior_log_odds": "1.380961",
  "not_applicable_reason": null,
  "independence_unreviewed": 3
}