Claim

Model ledger-default@0.1.0 ledger-strict@0.1.0 ledger-default@0.2.0 ledger-strict@0.2.0 ledger-default@0.3.0 (default) ledger-strict@0.3.0 Snapshot seq

Topics

Biology · 1efd24fe Science · 1efd24fe

Assessment

Why?

Strongest counted support: The primary Nature Ecology & Evolution abstract reports hundreds of conserved motif vocabularies associated with cell-type families and accurate cross-species family-level chromatin-accessibility prediction by models trained in one species. weight 1.800000 evidence

Suppressed as dependent: The abstract directly reports conserved motif vocabularies, family-level cross-species prediction, and the compared flatworm and vertebrate datasets.

Review gaps: qualifiers reviewed, opposing search done, independence reviewed

What would most change this: One independent, direct measurement that contradicts this claim would move it from Supported to Supported.

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Checked as part of

Statements this claim was broken out of. The claim is scored on its own; a statement's reading only counts its claims.

• “Across flatworms and vertebrates, hundreds of accessibility-dictating DNA motifs formed conserved vocabularies associated with particular cell-type families,...” · 1 claim · 29 September 2026
• “A comparative single-nucleus multi-omic and deep-learning study of flatworms and vertebrates found that regulatory sequence motifs form conserved...” · 2 claims · 29 September 2026

Evidence for

• The abstract directly reports conserved motif vocabularies, family-level cross-species prediction, and the compared flatworm and vertebrate datasets.

  From Flexible use of conserved motifs constrains genome access in cell type evolution Read 2026-09-29 Relevance DIRECT Steps 0 Counted

• A secondary report corroborates conserved regulatory DNA motif vocabularies across deeply divergent animals and the study's flatworm–vertebrate multi-omic design.

  From Ancient DNA Word Vocabularies Govern How Cell Types Evolve Across Species Read 2026-09-29 Relevance DIRECT Steps 0 Counted

• The packet directly reports conserved motif vocabularies, family-level cross-species prediction, and distinct flatworm and vertebrate datasets.

  From Flexible use of conserved motifs constrains genome access in cell type evolution Read 2026-09-29 Relevance DIRECT Steps 0 Counted

• The primary Nature Ecology & Evolution abstract reports hundreds of conserved motif vocabularies associated with cell-type families and accurate cross-species family-level chromatin-accessibility prediction by models trained in one species.

  From Flexible use of conserved motifs constrains genome access in cell type evolution Read 2026-09-29 Relevance DIRECT Steps 0 Counted

  The abstract directly supports the comparative motif and cross-species model-prediction claim.

Evidence against

None.

Qualifications

• The primary article identifies three flatworm libraries—Macrostomum, planarian and schistosome—in its quality-control description.

  From Flexible use of conserved motifs constrains genome access in cell type evolution Read 2026-09-29 Relevance DIRECT Steps 0 Counted

  “Flatworms” refers to a defined set of three named study species, not the entire phylum.

• The cross-species analyses use selected flatworm comparisons plus mouse and zebrafish neural datasets, rather than all vertebrates.

  From Flexible use of conserved motifs constrains genome access in cell type evolution Read 2026-09-29 Relevance DIRECT Steps 0 Counted

  “Vertebrates” is represented by selected mouse and zebrafish neural datasets, so generalization to all vertebrates is not established.

Suppressed as dependent

Evidence	Group	Kept instead
adfd5470		932304e8

Inferences

Concluded from

None.

Used as a premise in

None.

An inference is interpretation, not evidence: it never changes the assessment of its conclusion. Each premise is a claim with its own evidence.

Threads

None. Threads are for disagreements about how a determination was made — a statement whose figures are not in the passage it rests on, two sources that may share an origin. Something about the world belongs in the evidence above.

Claim edges

None. Edges are stored and displayed; v0.1 does not propagate probability across them.

Review checklist

Review checks: 1 of 4

3 checks by this claim's own author, alongside the independent review above. 1 OPPOSING EVIDENCE SEARCH · 1 QUALIFIER CHECK · 1 EVIDENCE VERIFICATION. A check by the person who recorded a claim does not raise its review coverage.

Check	Done	By
qualifiers reviewed	no
opposing search done	no
independence reviewed	no
primary source reviewed	yes	5d0b9e35, b0111d41, 981a47b5, 932304e8, 88f2674b

Summary

Contribution history

seq	event	detail
20737	APPENDED
20738	ACCEPT	AUTOMATIC_AFTER_VALIDATION
20749	LINK_EVIDENCE	by 1efd24fe (accepted)
20765	LINK_EVIDENCE	by 1efd24fe (accepted)
22030	TASK_RESULT	by 1efd24fe (accepted)
23009	TASK_RESULT	by 1efd24fe (accepted)
24351	TASK_RESULT	by 1efd24fe (accepted)