Claim

Model ledger-default@0.1.0 ledger-strict@0.1.0 ledger-default@0.2.0 ledger-strict@0.2.0 ledger-default@0.3.0 (default) ledger-strict@0.3.0 Snapshot seq

Topics

Biology · 1efd24fe Chemistry · 1efd24fe

Assessment

Why?

Strongest counted support: The primary study reports a 2.52-angstrom cryo-EM structure of IMP-2380 bound to outward-open NorA. weight 2.000000 evidence

Suppressed as dependent: The quoted passage directly reports the 2.52-angstrom cryo-EM NorA–IMP-2380 structure, outward-open conformation, and occlusion of the cytosolic substrate-binding cavity.

Review gaps: qualifiers reviewed, opposing search done, independence reviewed

What would most change this: One independent, direct measurement that contradicts this claim would move it from Supported to Unresolved.

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Checked as part of

Statements this claim was broken out of. The claim is scored on its own; a statement's reading only counts its claims.

• “A 2026 study characterized IMP-2380 as a NorA efflux inhibitor that potentiated ciprofloxacin against MRSA and revealed its binding mode by cryo-EM.” · 2 claims · 29 September 2026

Evidence for

• The primary study reports a 2.52-angstrom cryo-EM structure of IMP-2380 bound to outward-open NorA.

  From Small-molecule inhibitors block NorA efflux by conformational trapping Read 2026-09-29 Relevance DIRECT Steps 0 Counted

  Primary cryo-EM structural result.

• The quoted passage directly reports the 2.52-angstrom cryo-EM NorA–IMP-2380 structure, outward-open conformation, and occlusion of the cytosolic substrate-binding cavity.

  From Small-molecule inhibitors block NorA efflux by conformational trapping Read 2026-09-29 Relevance DIRECT Steps 0 Counted

  The excerpt states the resolution, complex, conformation, and cavity occlusion.

Evidence against

None.

Qualifications

None.

Suppressed as dependent

Evidence	Group	Kept instead
0398a188		da582635

Inferences

Concluded from

None.

Used as a premise in

None.

An inference is interpretation, not evidence: it never changes the assessment of its conclusion. Each premise is a claim with its own evidence.

Threads

None. Threads are for disagreements about how a determination was made — a statement whose figures are not in the passage it rests on, two sources that may share an origin. Something about the world belongs in the evidence above.

Claim edges

None. Edges are stored and displayed; v0.1 does not propagate probability across them.

Review checklist

Review checks: 1 of 4

2 checks by this claim's own author, alongside the independent review above. 1 QUALIFIER CHECK · 1 EVIDENCE VERIFICATION. A check by the person who recorded a claim does not raise its review coverage.

Check	Done	By
qualifiers reviewed	no
opposing search done	no
independence reviewed	no
primary source reviewed	yes	da582635, 4dfa3fab

Summary

Contribution history

seq	event	detail
18486	APPENDED
18487	ACCEPT	AUTOMATIC_AFTER_VALIDATION
18496	LINK_EVIDENCE	by 1efd24fe (accepted)
24717	TASK_RESULT	by 1efd24fe (accepted)

Score trace

{
  "claim": "5d60e455-d46c-857b-ba95-154befcd59ae",
  "links": [
    {
      "link": "a2727d09-2e8c-8362-9097-016dda582635",
      "group": null,
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "64939c5c-2084-8aa6-8c3f-9d368692d824",
      "direction": "SUPPORT",
      "magnitude": "2.000000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "MEASUREMENT",
      "source_type": "PRIMARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "2.000000",
      "interpretive_steps": 0
    },
    {
      "kept": "a2727d09-2e8c-8362-9097-016dda582635",
      "link": "e0ef37ba-aea5-8ede-9dcc-126f4dfa3fab",
      "group": null,
      "reason": "dependent_strongest_only",
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "bcdce0e7-e8b8-8a63-9446-71060398a188",
      "direction": "SUPPORT",
      "magnitude": "1.800000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "DIRECT_TEXT",
      "source_type": "PRIMARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "0.000000",
      "interpretive_steps": 0
    }
  ],
  "model": "ledger-default@0.3.0",
  "prior": "0.50",
  "variants": {
    "spread": "0.1287",
    "permissive": "0.9309",
    "conservative": "0.8022"
  },
  "code_hash": "sha256:c61a6fdf35a754a0d7e958df149036a083c0eaeb7d2d2e52704ec32b0c36def7",
  "contested": false,
  "stability": "MEDIUM",
  "claim_type": "OBSERVATIONAL",
  "config_hash": "sha256:86768038080b8ab5233f1e4b7aba10af05b5bb44caa432095150b90e81209809",
  "probability": "0.8808",
  "provisional": true,
  "evidence_sum": "2.000000",
  "snapshot_seq": 25892,
  "prior_log_odds": "0.000000",
  "support_groups": 1,
  "model_dependent": false,
  "review_coverage": "0.25",
  "truth_evaluable": true,
  "assessment_state": "SUPPORTED",
  "review_checklist": {
    "qualifiers_reviewed": {
      "by": [],
      "ok": false
    },
    "opposing_search_done": {
      "by": [],
      "ok": false
    },
    "independence_reviewed": {
      "by": [],
      "ok": false
    },
    "primary_source_reviewed": {
      "by": [
        "a2727d09-2e8c-8362-9097-016dda582635",
        "e0ef37ba-aea5-8ede-9dcc-126f4dfa3fab"
      ],
      "ok": true
    }
  },
  "contradict_groups": 0,
  "rounding_boundary": false,
  "posterior_log_odds": "2.000000",
  "not_applicable_reason": null,
  "independence_unreviewed": 2
}