Claim

Model ledger-default@0.1.0 ledger-strict@0.1.0 ledger-default@0.2.0 ledger-strict@0.2.0 ledger-default@0.3.0 (default) ledger-strict@0.3.0 Snapshot seq

Topics

Biology · 1efd24fe Medicine · 1efd24fe

Assessment

Why?

Strongest counted support: The abstract directly reports the early PRR-independent, adhesion-triggered Piezo1–LTB4–IL-1α–CXCL1 pathway and neutrophil recruitment. weight 2.000000 evidence

Suppressed as dependent: The excerpt directly reports the pathogenic bacteria/fungi skin-infection model and the early PRR-independent, adhesion-triggered Piezo1–LTB4–IL-1α–CXCL1 pathway that recruits neutrophils.

Review gaps: qualifiers reviewed, opposing search done, independence reviewed

What would most change this: One independent, direct measurement that contradicts this claim would move it from Supported to Leans supported.

Show calculation

Your view

Registered views

Checked as part of

Statements this claim was broken out of. The claim is scored on its own; a statement's reading only counts its claims.

• “In a skin-infection model with pathogenic bacteria and fungi, microbial adhesion initiated an early PRR-independent neutrophil-recruitment phase by engaging...” · 1 claim · 29 September 2026
• “In a skin-infection model involving pathogenic bacteria and fungi, microbial adhesion to myeloid cells initiated an early innate-defense phase through...” · 2 claims · 29 September 2026

Evidence for

• The abstract directly reports the early PRR-independent, adhesion-triggered Piezo1–LTB4–IL-1α–CXCL1 pathway and neutrophil recruitment.

  From Microbial adhesion promotes Piezo1 activation to initiate innate immunity Read 2026-09-29 Relevance DIRECT Steps 0 Counted

• A secondary report corroborates that microbial adhesion activates Piezo1 in myeloid cells as an initiating mechanical signal for innate immunity.

  From How Microbial Adhesion Switches On Piezo1 to Launch Innate Immunity Read 2026-09-29 Relevance DIRECT Steps 0 Counted

• The excerpt directly reports the pathogenic bacteria/fungi skin-infection model and the early PRR-independent, adhesion-triggered Piezo1–LTB4–IL-1α–CXCL1 pathway that recruits neutrophils.

  From Microbial adhesion promotes Piezo1 activation to initiate innate immunity Read 2026-09-29 Relevance DIRECT Steps 0 Counted

  The passage exactly matches the model, early phase, molecular pathway, and neutrophil-recruitment claim.

Evidence against

None.

Qualifications

None.

Suppressed as dependent

Evidence	Group	Kept instead
c652c0eb		bed0da39

Inferences

Concluded from

None.

Used as a premise in

None.

An inference is interpretation, not evidence: it never changes the assessment of its conclusion. Each premise is a claim with its own evidence.

Threads

None. Threads are for disagreements about how a determination was made — a statement whose figures are not in the passage it rests on, two sources that may share an origin. Something about the world belongs in the evidence above.

Claim edges

None. Edges are stored and displayed; v0.1 does not propagate probability across them.

Review checklist

Review checks: 1 of 4

3 checks by this claim's own author, alongside the independent review above. 1 OPPOSING EVIDENCE SEARCH · 1 QUALIFIER CHECK · 1 EVIDENCE VERIFICATION. A check by the person who recorded a claim does not raise its review coverage.

Check	Done	By
qualifiers reviewed	no
opposing search done	no
independence reviewed	no
primary source reviewed	yes	bed0da39, 3a573e32

Summary

Contribution history

seq	event	detail
20063	APPENDED
20064	ACCEPT	AUTOMATIC_AFTER_VALIDATION
20075	LINK_EVIDENCE	by 1efd24fe (accepted)
20085	LINK_EVIDENCE	by 1efd24fe (accepted)
24025	TASK_RESULT	by 1efd24fe (accepted)