Claim

In a skin-infection model with pathogenic bacteria and fungi, microbial adhesion initiated an early PRR-independent neutrophil-recruitment phase by engaging Piezo1 and promoting leukotriene B4, interleukin-1α, and CXCL1 signaling.

Type CAUSAL · truth-evaluable: yes · status at snapshot: ACTIVE · created seq 20063 · qualifiers {"model":"Skin infection model involving pathogenic bacteria and fungi; the result is preclinical."}

28 words; atomic claims are usually under 25a conjunction joins clauses that may be separately evaluablea comma-separated series may list several propositions

Referenced 116 times: checked 2, looked up by assistants 0, viewed 73, shared 41. A count of attention, not evidence.

Topics

Biology · 1efd24fe Medicine · 1efd24fe

Assessment

Supported

Score: 0.9601 under ledger-default@0.3.0 at snapshot 27745

3 of 4 review checks done · 1 counted · 2 by the author only

2 independent evidence lineages · review checks 1 of 4 · stability LOW

Main unresolved issue: 3 counted evidence items have no independence review; repeats of one origin may be counted as several coverage:6499fa72-25ab-8012-934e-735cee5b6350

Not yet independently audited.This assessment depends heavily on modeling choices.Evidence reviewed so far supports this claim, but only 1 of 4 review checks has been done.Every quoted passage was confirmed on the page when Galedra fetched it.

Why?

Strongest counted support: The abstract directly reports the early PRR-independent, adhesion-triggered Piezo1–LTB4–IL-1α–CXCL1 pathway and neutrophil recruitment. weight 2.000000 evidence

Suppressed as dependent: The excerpt directly reports the pathogenic bacteria/fungi skin-infection model and the early PRR-independent, adhesion-triggered Piezo1–LTB4–IL-1α–CXCL1 pathway that recruits neutrophils.

Review gaps: qualifiers reviewed, opposing search done, independence reviewed

What would most change this: One independent, direct measurement that contradicts this claim would move it from Supported to Leans supported.

Hide calculation

0.9601 under ledger-default@0.3.0 at snapshot 27745 · state Supported · Review checks: 1 of 4 · stability LOW · 3 sources, 2 independent lineages

Model ledger-default@0.3.0 (the default model, not the answer) · snapshot 27745 · trace sha256:4e398156c132b924a059e1952d7ee65ba79c7b86058d8f27d7444c61609d722a

Last changed at entry seq 25736; nothing logged since has borne on this claim.

How the number was reached

Each counted link is weighed by multiplying the factors the model declares; a factor it does not declare is not shown. Every factor name below links to what that number means.

Link	Working	Weight	Counted as
bed0da39 support	relevance DIRECT 2.0 × observation MEASUREMENT 1.0 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	2.000000	2.000000
3a573e32 support	relevance DIRECT 2.0 × observation DIRECT_TEXT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.800000	0.000000 (dependent strongest only, kept bed0da39)
dc49a900 support	relevance DIRECT 2.0 × observation DIRECT_TEXT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.800000	1.800000

prior 0.35 → log-odds -0.619039 + 3.800000 (the counted weights) = 3.180961 → probability 0.9601

Under neighbouring settings of the same model: 0.8850 to 0.9869, a spread of 0.1019.

Half-even rounding, six places for weights and four for the probability. The same inputs under the same model reproduce this exactly; that is what the trace hash above is for. How a score is worked out explains every factor, why it is there, and what the model sets it to.

Your view

Registered views

Nobody has registered a view yet.

Registered views are personal belief, not evidence: they never change Galedra's assessment. Affiliations are self-declared and shown only for groups of 5 or more.

Checked as part of

Statements this claim was broken out of. The claim is scored on its own; a statement's reading only counts its claims.

“In a skin-infection model with pathogenic bacteria and fungi, microbial adhesion initiated an early PRR-independent neutrophil-recruitment phase by engaging...” · 1 claim · 29 September 2026
“In a skin-infection model involving pathogenic bacteria and fungi, microbial adhesion to myeloid cells initiated an early innate-defense phase through...” · 2 claims · 29 September 2026

Evidence for

The abstract directly reports the early PRR-independent, adhesion-triggered Piezo1–LTB4–IL-1α–CXCL1 pathway and neutrophil recruitment.

From Microbial adhesion promotes Piezo1 activation to initiate innate immunity Read 2026-09-29 Relevance DIRECT Steps 0 Counted
A secondary report corroborates that microbial adhesion activates Piezo1 in myeloid cells as an initiating mechanical signal for innate immunity.

From How Microbial Adhesion Switches On Piezo1 to Launch Innate Immunity Read 2026-09-29 Relevance DIRECT Steps 0 Counted
The excerpt directly reports the pathogenic bacteria/fungi skin-infection model and the early PRR-independent, adhesion-triggered Piezo1–LTB4–IL-1α–CXCL1 pathway that recruits neutrophils.

From Microbial adhesion promotes Piezo1 activation to initiate innate immunity Read 2026-09-29 Relevance DIRECT Steps 0 Counted

The passage exactly matches the model, early phase, molecular pathway, and neutrophil-recruitment claim.

Evidence against

None.

Qualifications

None.

Suppressed as dependent

Evidence	Group	Kept instead
c652c0eb		bed0da39

Inferences

Concluded from

None.

Used as a premise in

None.

An inference is interpretation, not evidence: it never changes the assessment of its conclusion. Each premise is a claim with its own evidence.

Threads

None. Threads are for disagreements about how a determination was made — a statement whose figures are not in the passage it rests on, two sources that may share an origin. Something about the world belongs in the evidence above.

Claim edges

None. Edges are stored and displayed; v0.1 does not propagate probability across them.

Review checklist

Review checks: 1 of 4

3 checks by this claim's own author, alongside the independent review above. 1 OPPOSING EVIDENCE SEARCH · 1 QUALIFIER CHECK · 1 EVIDENCE VERIFICATION. A check by the person who recorded a claim does not raise its review coverage.

Check	Done	By
qualifiers reviewed	no
opposing search done	no
independence reviewed	no
primary source reviewed	yes	bed0da39, 3a573e32

Summary

Supported. The main support is: The abstract directly reports the early PRR-independent, adhesion-triggered Piezo1–LTB4–IL-1α–CXCL1 pathway and neutrophil recruitment. 2973c5ef

1 further item repeats the same origin and is not independent evidence. c652c0eb

A search for evidence in the opposing direction found none. 6eb21ed2

Review checks: 1 of 4. coverage:6499fa72-25ab-8012-934e-735cee5b6350

Generated by stub-v0.1; every sentence cites graph ids.

Contribution history

seq	event	detail
20063	APPENDED
20064	ACCEPT	AUTOMATIC_AFTER_VALIDATION
20075	LINK_EVIDENCE	by 1efd24fe (accepted)
20085	LINK_EVIDENCE	by 1efd24fe (accepted)
24025	TASK_RESULT	by 1efd24fe (accepted)

Score trace

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  "claim": "6499fa72-25ab-8012-934e-735cee5b6350",
  "links": [
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      "link": "71dbca60-4ca8-869c-80f6-7987bed0da39",
      "group": null,
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      "direction": "SUPPORT",
      "magnitude": "2.000000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "MEASUREMENT",
      "source_type": "PRIMARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
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      "interpretive_steps": 0
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      "link": "cdc8275d-b187-8eff-a474-2a5f3a573e32",
      "group": null,
      "reason": "dependent_strongest_only",
      "edition": "NAMED_OR_UNRELATED",
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      "direction": "SUPPORT",
      "magnitude": "1.800000",
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      "extraction": "UNVERIFIED",
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      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "0.000000",
      "interpretive_steps": 0
    },
    {
      "link": "eb194dba-d895-80a9-b839-d30adc49a900",
      "group": null,
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "50384027-d568-85bd-86c2-ba93e32aed65",
      "direction": "SUPPORT",
      "magnitude": "1.800000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "DIRECT_TEXT",
      "source_type": "SECONDARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "1.800000",
      "interpretive_steps": 0
    }
  ],
  "model": "ledger-default@0.3.0",
  "prior": "0.35",
  "variants": {
    "spread": "0.1019",
    "permissive": "0.9869",
    "conservative": "0.8850"
  },
  "code_hash": "sha256:c61a6fdf35a754a0d7e958df149036a083c0eaeb7d2d2e52704ec32b0c36def7",
  "contested": false,
  "stability": "LOW",
  "claim_type": "CAUSAL",
  "config_hash": "sha256:86768038080b8ab5233f1e4b7aba10af05b5bb44caa432095150b90e81209809",
  "probability": "0.9601",
  "provisional": true,
  "evidence_sum": "3.800000",
  "snapshot_seq": 25736,
  "prior_log_odds": "-0.619039",
  "support_groups": 2,
  "model_dependent": true,
  "review_coverage": "0.25",
  "truth_evaluable": true,
  "assessment_state": "SUPPORTED",
  "review_checklist": {
    "qualifiers_reviewed": {
      "by": [],
      "ok": false
    },
    "opposing_search_done": {
      "by": [],
      "ok": false
    },
    "independence_reviewed": {
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      "ok": false
    },
    "primary_source_reviewed": {
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      ],
      "ok": true
    }
  },
  "contradict_groups": 0,
  "rounding_boundary": false,
  "posterior_log_odds": "3.180961",
  "not_applicable_reason": null,
  "independence_unreviewed": 3
}