Claim

The yolk-sac-origin statement is atlas-based support from paired single-nuclei RNA/ATAC and spatial data collected across human cranial meningeal development at 6–21 post-conception weeks; it is not presented here as direct lineage tracing across all development.

Type INTERPRETIVE · truth-evaluable: yes · status at snapshot: ACTIVE · created seq 25721

35 words; atomic claims are usually under 25a conjunction joins clauses that may be separately evaluable

Referenced 92 times: checked 0, looked up by assistants 0, viewed 92, shared 0. A count of attention, not evidence.

Topics

Not filed under any topic yet.

Assessment

Supported

Score: 0.8581 under ledger-default@0.3.0 at snapshot 27745

3 of 4 review checks done · 1 counted · 2 by the author only

1 independent evidence lineage · review checks 1 of 4 · stability LOW

Main unresolved issue: 1 counted evidence item has no independence review; repeats of one origin may be counted as several coverage:6836e7f8-243e-8f6b-ad9b-0231aed2f1d4

Not yet independently audited.This assessment depends heavily on modeling choices.Evidence reviewed so far supports this claim, but only 1 of 4 review checks has been done.

Related: NARROWS outgoing: Supported

Why?

Strongest counted support: The human meningeal atlas directly supports a yolk-sac-origin interpretation using paired single-nuclei and spatial data sampled from 17 donors across 6–21 post-conception weeks. weight 1.800000 evidence

Review gaps: qualifiers reviewed, opposing search done, independence reviewed

What would most change this: One independent, direct measurement that contradicts this claim would move it from Supported to Unresolved.

Hide calculation

0.8581 under ledger-default@0.3.0 at snapshot 27745 · state Supported · Review checks: 1 of 4 · stability LOW · 1 source, 1 independent lineage

Model ledger-default@0.3.0 (the default model, not the answer) · snapshot 27745 · trace sha256:3c3aaad873357ed2c0955bde0eecf13111dd332d2fa03bdd2491f598dd3a21b9

Last changed at entry seq 25728; nothing logged since has borne on this claim.

How the number was reached

Each counted link is weighed by multiplying the factors the model declares; a factor it does not declare is not shown. Every factor name below links to what that number means.

Link	Working	Weight	Counted as
d7d85156 support	relevance DIRECT 2.0 × observation DATASET_RESULT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.800000	1.800000

prior 0.50 → log-odds 0.000000 + 1.800000 (the counted weights) = 1.800000 → probability 0.8581

Under neighbouring settings of the same model: 0.7790 to 0.9121, a spread of 0.1331.

Half-even rounding, six places for weights and four for the probability. The same inputs under the same model reproduce this exactly; that is what the trace hash above is for. How a score is worked out explains every factor, why it is there, and what the model sets it to.

Your view

Registered views

Nobody has registered a view yet.

Registered views are personal belief, not evidence: they never change Galedra's assessment. Affiliations are self-declared and shown only for groups of 5 or more.

Evidence for

The human meningeal atlas directly supports a yolk-sac-origin interpretation using paired single-nuclei and spatial data sampled from 17 donors across 6–21 post-conception weeks.

From Spatially resolved multiomics of human meningeal development reveal lineage and disease dynamics Read 2026-09-29 Relevance DIRECT Steps 0 Counted

Independent primary text supports the atlas-based scope and explicitly says the data support yolk-sac origin for meningeal myeloid lineages.

Evidence against

None.

Qualifications

None.

Suppressed as dependent

None.

Inferences

Concluded from

None.

Used as a premise in

None.

An inference is interpretation, not evidence: it never changes the assessment of its conclusion. Each premise is a claim with its own evidence.

Threads

None. Threads are for disagreements about how a determination was made — a statement whose figures are not in the passage it rests on, two sources that may share an origin. Something about the world belongs in the evidence above.

Claim edges

From	Relationship	To
aed2f1d4	NARROWS	def9e18a

Review checklist

Review checks: 1 of 4

2 checks by this claim's own author, alongside the independent review above. 1 OPPOSING EVIDENCE SEARCH · 1 QUALIFIER CHECK. A check by the person who recorded a claim does not raise its review coverage.

Check	Done	By
qualifiers reviewed	no
opposing search done	no
independence reviewed	no
primary source reviewed	yes	d7d85156

Summary

Supported. The main support is: The human meningeal atlas directly supports a yolk-sac-origin interpretation using paired single-nuclei and spatial data sampled from 17 donors across 6–21 post-conception weeks. bca08741

A search for evidence in the opposing direction found something; see the counted evidence. 1d967a07

Review checks: 1 of 4. coverage:6836e7f8-243e-8f6b-ad9b-0231aed2f1d4

Generated by stub-v0.1; every sentence cites graph ids.

Contribution history

seq	event	detail
25721	APPENDED
25722	ACCEPT	AUTOMATIC_AFTER_VALIDATION
25727	TASK_RESULT	by 1efd24fe (accepted)

Score trace

{
  "claim": "6836e7f8-243e-8f6b-ad9b-0231aed2f1d4",
  "links": [
    {
      "link": "4c1e20f6-1a4d-8ef9-886f-997dd7d85156",
      "group": null,
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "2c6a361f-7c12-8b34-add2-673bbca08741",
      "direction": "SUPPORT",
      "magnitude": "1.800000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "DATASET_RESULT",
      "source_type": "PRIMARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "1.800000",
      "interpretive_steps": 0
    }
  ],
  "model": "ledger-default@0.3.0",
  "prior": "0.50",
  "variants": {
    "spread": "0.1331",
    "permissive": "0.9121",
    "conservative": "0.7790"
  },
  "code_hash": "sha256:c61a6fdf35a754a0d7e958df149036a083c0eaeb7d2d2e52704ec32b0c36def7",
  "contested": false,
  "stability": "LOW",
  "claim_type": "INTERPRETIVE",
  "config_hash": "sha256:86768038080b8ab5233f1e4b7aba10af05b5bb44caa432095150b90e81209809",
  "probability": "0.8581",
  "provisional": true,
  "evidence_sum": "1.800000",
  "snapshot_seq": 25728,
  "prior_log_odds": "0.000000",
  "support_groups": 1,
  "model_dependent": true,
  "review_coverage": "0.25",
  "truth_evaluable": true,
  "assessment_state": "SUPPORTED",
  "review_checklist": {
    "qualifiers_reviewed": {
      "by": [],
      "ok": false
    },
    "opposing_search_done": {
      "by": [],
      "ok": false
    },
    "independence_reviewed": {
      "by": [],
      "ok": false
    },
    "primary_source_reviewed": {
      "by": [
        "4c1e20f6-1a4d-8ef9-886f-997dd7d85156"
      ],
      "ok": true
    }
  },
  "contradict_groups": 0,
  "rounding_boundary": false,
  "posterior_log_odds": "1.800000",
  "not_applicable_reason": null,
  "independence_unreviewed": 1
}