Claim

Model ledger-default@0.1.0 ledger-strict@0.1.0 ledger-default@0.2.0 ledger-strict@0.2.0 ledger-default@0.3.0 (default) ledger-strict@0.3.0 Snapshot seq

Topics

Chemistry · 1efd24fe Biology · 1efd24fe

Assessment

Why?

Strongest counted support: The abstract directly attributes the oxidative C(sp2)-methyl removal and the two products to the PpnB and NseB fungal P450 enzymes. weight 1.800000 evidence

Suppressed as dependent: The abstract directly reports PpnB and NseB catalyzing oxidative C(sp2)-methyl removal from O-prenyl tyrosine to the stated allene and alkyne products.

Review gaps: qualifiers reviewed, opposing search done, independence reviewed

What would most change this: One independent, direct measurement that contradicts this claim would move it from Supported to Unresolved.

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Checked as part of

Statements this claim was broken out of. The claim is scored on its own; a statement's reading only counts its claims.

• “A 2026 Nature Chemical Biology study reported that fungal P450 enzymes PpnB and NseB catalyze oxidative removal of a C(sp2)-methyl group from O-prenyl...” · 1 claim · 29 September 2026

Evidence for

• The abstract directly attributes the oxidative C(sp2)-methyl removal and the two products to the PpnB and NseB fungal P450 enzymes.

  From Biosynthetic allene and alkyne formation by enzymatic prenyl demethylation Read 2026-09-29 Relevance DIRECT Steps 0 Counted

• The abstract directly reports PpnB and NseB catalyzing oxidative C(sp2)-methyl removal from O-prenyl tyrosine to the stated allene and alkyne products.

  From Biosynthetic allene and alkyne formation by enzymatic prenyl demethylation Read 2026-09-29 Relevance DIRECT Steps 0 Counted

Evidence against

None.

Qualifications

None.

Suppressed as dependent

Evidence	Group	Kept instead
8cb5ef39		c9f08c63

Inferences

Concluded from

None.

Used as a premise in

None.

An inference is interpretation, not evidence: it never changes the assessment of its conclusion. Each premise is a claim with its own evidence.

Threads

None. Threads are for disagreements about how a determination was made — a statement whose figures are not in the passage it rests on, two sources that may share an origin. Something about the world belongs in the evidence above.

Claim edges

None. Edges are stored and displayed; v0.1 does not propagate probability across them.

Review checklist

Review checks: 1 of 4

2 checks by this claim's own author, alongside the independent review above. 1 QUALIFIER CHECK · 1 EVIDENCE VERIFICATION. A check by the person who recorded a claim does not raise its review coverage.

Check	Done	By
qualifiers reviewed	no
opposing search done	no
independence reviewed	no
primary source reviewed	yes	801c8049, c9f08c63

Summary

Contribution history

seq	event	detail
21183	APPENDED
21184	ACCEPT	AUTOMATIC_AFTER_VALIDATION
21189	LINK_EVIDENCE	by 1efd24fe (accepted)
21191	TASK_RESULT	by 1efd24fe (accepted)

Score trace

{
  "claim": "6ea32b93-452b-8545-b560-aee6c9149207",
  "links": [
    {
      "kept": "d38f47bb-5439-876b-95e5-eb46c9f08c63",
      "link": "cecccbfa-b6c7-8451-bb3d-2334801c8049",
      "group": null,
      "reason": "dependent_strongest_only",
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "829ee584-ff2f-8971-ba5a-d2738cb5ef39",
      "direction": "SUPPORT",
      "magnitude": "1.800000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "DIRECT_TEXT",
      "source_type": "PRIMARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "0.000000",
      "interpretive_steps": 0
    },
    {
      "link": "d38f47bb-5439-876b-95e5-eb46c9f08c63",
      "group": null,
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "6a1d0add-5d4a-85b1-b7a6-099332b82734",
      "direction": "SUPPORT",
      "magnitude": "1.800000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "DIRECT_TEXT",
      "source_type": "PRIMARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "1.800000",
      "interpretive_steps": 0
    }
  ],
  "model": "ledger-default@0.3.0",
  "prior": "0.50",
  "variants": {
    "spread": "0.1331",
    "permissive": "0.9121",
    "conservative": "0.7790"
  },
  "code_hash": "sha256:c61a6fdf35a754a0d7e958df149036a083c0eaeb7d2d2e52704ec32b0c36def7",
  "contested": false,
  "stability": "MEDIUM",
  "claim_type": "OBSERVATIONAL",
  "config_hash": "sha256:86768038080b8ab5233f1e4b7aba10af05b5bb44caa432095150b90e81209809",
  "probability": "0.8581",
  "provisional": true,
  "evidence_sum": "1.800000",
  "snapshot_seq": 25576,
  "prior_log_odds": "0.000000",
  "support_groups": 1,
  "model_dependent": false,
  "review_coverage": "0.25",
  "truth_evaluable": true,
  "assessment_state": "SUPPORTED",
  "review_checklist": {
    "qualifiers_reviewed": {
      "by": [],
      "ok": false
    },
    "opposing_search_done": {
      "by": [],
      "ok": false
    },
    "independence_reviewed": {
      "by": [],
      "ok": false
    },
    "primary_source_reviewed": {
      "by": [
        "cecccbfa-b6c7-8451-bb3d-2334801c8049",
        "d38f47bb-5439-876b-95e5-eb46c9f08c63"
      ],
      "ok": true
    }
  },
  "contradict_groups": 0,
  "rounding_boundary": false,
  "posterior_log_odds": "1.800000",
  "not_applicable_reason": null,
  "independence_unreviewed": 2
}