Claim

Model ledger-default@0.1.0 ledger-strict@0.1.0 ledger-default@0.2.0 ledger-strict@0.2.0 ledger-default@0.3.0 (default) ledger-strict@0.3.0 Snapshot seq

Topics

Biology · 1efd24fe

Assessment

Why?

Strongest counted support: The primary study reports stronger rare-codon reporter protein increases and preferential endogenous-protein increases after targeted PAXT-component loss. weight 1.800000 evidence

Suppressed as dependent: The quoted passage directly reports preferential increases in poorly expressed, long endogenous proteins enriched in rare codons after PAXT-component loss.

Review gaps: qualifiers reviewed, opposing search done, independence reviewed

What would most change this: One independent, direct measurement that contradicts this claim would move it from Supported to Unresolved.

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Checked as part of

Statements this claim was broken out of. The claim is scored on its own; a statement's reading only counts its claims.

• “In the study's reporter and omics experiments, disrupting the PAXT connection preferentially increases expression of rare-codon-enriched transcripts and...” · 2 claims · 29 September 2026

Evidence for

• The primary study reports stronger rare-codon reporter protein increases and preferential endogenous-protein increases after targeted PAXT-component loss.

  From The PAXT connection is a modifier of rare codon-enriched protein expression Read 2026-09-29 Relevance DIRECT Steps 0 Counted

  The abstract directly reports the transcriptomics-proteomics result for endogenous proteins.

• The quoted passage directly reports preferential increases in poorly expressed, long endogenous proteins enriched in rare codons after PAXT-component loss.

  From The PAXT connection is a modifier of rare codon-enriched protein expression Read 2026-09-29 Relevance DIRECT Steps 0 Counted

  The excerpt states the perturbation, transcriptomics-proteomics result, and encoded-protein characteristics.

Evidence against

None.

Qualifications

• The result is based on targeted PAXT loss, reporter comparisons, and selected transcriptome/proteome profiles rather than a universal effect across organisms or all PAXT substrates.

  From The PAXT connection is a modifier of rare codon-enriched protein expression Read 2026-09-29 Relevance DIRECT Steps 0 Counted

  Adds perturbation, reporter, assay, and dataset-population limits.

Suppressed as dependent

Evidence	Group	Kept instead
6fb60a95		d6ac0411

Inferences

Concluded from

None.

Used as a premise in

None.

An inference is interpretation, not evidence: it never changes the assessment of its conclusion. Each premise is a claim with its own evidence.

Threads

None. Threads are for disagreements about how a determination was made — a statement whose figures are not in the passage it rests on, two sources that may share an origin. Something about the world belongs in the evidence above.

Claim edges

None. Edges are stored and displayed; v0.1 does not propagate probability across them.

Review checklist

Review checks: 1 of 4

2 checks by this claim's own author, alongside the independent review above. 1 QUALIFIER CHECK · 1 EVIDENCE VERIFICATION. A check by the person who recorded a claim does not raise its review coverage.

Check	Done	By
qualifiers reviewed	no
opposing search done	no
independence reviewed	no
primary source reviewed	yes	f82677fb, c20aa94a, d6ac0411

Summary

Contribution history

seq	event	detail
21673	APPENDED
21674	ACCEPT	AUTOMATIC_AFTER_VALIDATION
21681	LINK_EVIDENCE	by 1efd24fe (accepted)
24561	TASK_RESULT	by 1efd24fe (accepted)
25623	TASK_RESULT	by 1efd24fe (accepted)

Score trace

{
  "claim": "88b1cff1-eec4-8efe-b7cd-36b9260271df",
  "links": [
    {
      "link": "018a0ce5-1e60-8ad9-a73a-38a6f82677fb",
      "group": null,
      "reason": "non_directional",
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "fe31a3b4-fa40-828d-83a4-05f3eb8c1809",
      "direction": "QUALIFY",
      "magnitude": "2.000000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "MEASUREMENT",
      "source_type": "PRIMARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "0.000000",
      "interpretive_steps": 0
    },
    {
      "kept": "f9bdd020-1625-8d26-9866-b4e1d6ac0411",
      "link": "537924a0-964a-8c06-8b7e-596ac20aa94a",
      "group": null,
      "reason": "dependent_strongest_only",
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "9152d933-c2de-8b36-aed7-d8836fb60a95",
      "direction": "SUPPORT",
      "magnitude": "1.800000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "DIRECT_TEXT",
      "source_type": "PRIMARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "0.000000",
      "interpretive_steps": 0
    },
    {
      "link": "f9bdd020-1625-8d26-9866-b4e1d6ac0411",
      "group": null,
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "4628db47-00d8-88dc-8cea-aa3c74a9a2fe",
      "direction": "SUPPORT",
      "magnitude": "1.800000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "DIRECT_TEXT",
      "source_type": "PRIMARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "1.800000",
      "interpretive_steps": 0
    }
  ],
  "model": "ledger-default@0.3.0",
  "prior": "0.50",
  "variants": {
    "spread": "0.1331",
    "permissive": "0.9121",
    "conservative": "0.7790"
  },
  "code_hash": "sha256:c61a6fdf35a754a0d7e958df149036a083c0eaeb7d2d2e52704ec32b0c36def7",
  "contested": false,
  "stability": "MEDIUM",
  "claim_type": "OBSERVATIONAL",
  "config_hash": "sha256:86768038080b8ab5233f1e4b7aba10af05b5bb44caa432095150b90e81209809",
  "probability": "0.8581",
  "provisional": true,
  "evidence_sum": "1.800000",
  "snapshot_seq": 25624,
  "prior_log_odds": "0.000000",
  "support_groups": 1,
  "model_dependent": false,
  "review_coverage": "0.25",
  "truth_evaluable": true,
  "assessment_state": "SUPPORTED",
  "review_checklist": {
    "qualifiers_reviewed": {
      "by": [],
      "ok": false
    },
    "opposing_search_done": {
      "by": [],
      "ok": false
    },
    "independence_reviewed": {
      "by": [],
      "ok": false
    },
    "primary_source_reviewed": {
      "by": [
        "018a0ce5-1e60-8ad9-a73a-38a6f82677fb",
        "537924a0-964a-8c06-8b7e-596ac20aa94a",
        "f9bdd020-1625-8d26-9866-b4e1d6ac0411"
      ],
      "ok": true
    }
  },
  "contradict_groups": 0,
  "rounding_boundary": false,
  "posterior_log_odds": "1.800000",
  "not_applicable_reason": null,
  "independence_unreviewed": 3
}