Claim

Model ledger-default@0.1.0 ledger-strict@0.1.0 ledger-default@0.2.0 ledger-strict@0.2.0 ledger-default@0.3.0 (default) ledger-strict@0.3.0 Snapshot seq

Topics

Medicine · 1efd24fe Biology · 1efd24fe

Assessment

Why?

Strongest counted support: The cohort found nine pathogenic germline diagnoses, six previously unrecognized, with surveillance or treatment consequences. weight 1.800000 evidence

Suppressed as dependent: The packet directly supports the 181-child cohort, nine diagnoses, six previously unrecognized cases, and surveillance or treatment consequences.

Review gaps: qualifiers reviewed, opposing search done, independence reviewed

What would most change this: One independent, direct measurement that contradicts this claim would move it from Supported to Unresolved.

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Checked as part of

Statements this claim was broken out of. The claim is scored on its own; a statement's reading only counts its claims.

• “In a nationwide prospective Swedish cohort of 181 children with acute leukemia, an integrated phenotyping, germline WGS panel, and tumor-sequencing strategy...” · 1 claim · 29 September 2026

Evidence for

• The cohort found nine pathogenic germline diagnoses, six previously unrecognized, with surveillance or treatment consequences.

  From Diagnostic yield of cancer predisposition in a nationwide prospective childhood acute leukemia cohort Read 2026-09-29 Relevance DIRECT Steps 0 Counted

• The packet directly supports the 181-child cohort, nine diagnoses, six previously unrecognized cases, and surveillance or treatment consequences.

  From Diagnostic yield of cancer predisposition in a nationwide prospective childhood acute leukemia cohort Read 2026-09-29 Relevance DIRECT Steps 0 Counted

Evidence against

None.

Qualifications

• The reported 5.0% yield and 8/9 and 4/9 clinical-actionability figures are bounded by the 181-child consented Swedish cohort, its recruitment dates and subtype mix, and distinct denominators; the study did not include all 213 registry diagnoses.

  From Diagnostic yield of cancer predisposition in a nationwide prospective childhood acute leukemia cohort Read 2026-09-29 Relevance DIRECT Steps 0 Counted

  Adds the cohort dates, age/subtype composition, six-center jurisdiction, consent-based coverage, component yield denominators, and management denominators.

Suppressed as dependent

Evidence	Group	Kept instead
ba79669c		f9857499

Inferences

Concluded from

None.

Used as a premise in

None.

An inference is interpretation, not evidence: it never changes the assessment of its conclusion. Each premise is a claim with its own evidence.

Threads

None. Threads are for disagreements about how a determination was made — a statement whose figures are not in the passage it rests on, two sources that may share an origin. Something about the world belongs in the evidence above.

Claim edges

None. Edges are stored and displayed; v0.1 does not propagate probability across them.

Review checklist

Review checks: 1 of 4

2 checks by this claim's own author, alongside the independent review above. 1 QUALIFIER CHECK · 1 EVIDENCE VERIFICATION. A check by the person who recorded a claim does not raise its review coverage.

Check	Done	By
qualifiers reviewed	no
opposing search done	no
independence reviewed	no
primary source reviewed	yes	3118398c, f9857499, 1e10608f

Summary

Contribution history

seq	event	detail
18154	APPENDED
18155	ACCEPT	AUTOMATIC_AFTER_VALIDATION
18160	LINK_EVIDENCE	by 1efd24fe (accepted)
18221	TASK_RESULT	by 1efd24fe (accepted)
25408	TASK_RESULT	by 1efd24fe (accepted)

Score trace

{
  "claim": "bc5d1e4c-2d4f-8861-a71a-7bd1d47ce4d6",
  "links": [
    {
      "kept": "6a8bb547-e0a0-87d2-ac5e-4756f9857499",
      "link": "19702a28-68af-86ac-81f2-da903118398c",
      "group": null,
      "reason": "dependent_strongest_only",
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "b7f371ba-c28f-8335-a297-65daba79669c",
      "direction": "SUPPORT",
      "magnitude": "1.800000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "DATASET_RESULT",
      "source_type": "PRIMARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "0.000000",
      "interpretive_steps": 0
    },
    {
      "link": "6a8bb547-e0a0-87d2-ac5e-4756f9857499",
      "group": null,
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "2aa4fca5-fd90-8058-a4b2-89d33c97a646",
      "direction": "SUPPORT",
      "magnitude": "1.800000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "DATASET_RESULT",
      "source_type": "PRIMARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "1.800000",
      "interpretive_steps": 0
    },
    {
      "link": "c311d57b-94de-810b-a066-86311e10608f",
      "group": null,
      "reason": "non_directional",
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "2ccd6272-0a0d-881f-8208-2806ef145ece",
      "direction": "QUALIFY",
      "magnitude": "2.000000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "MEASUREMENT",
      "source_type": "PRIMARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "0.000000",
      "interpretive_steps": 0
    }
  ],
  "model": "ledger-default@0.3.0",
  "prior": "0.50",
  "variants": {
    "spread": "0.1331",
    "permissive": "0.9121",
    "conservative": "0.7790"
  },
  "code_hash": "sha256:c61a6fdf35a754a0d7e958df149036a083c0eaeb7d2d2e52704ec32b0c36def7",
  "contested": false,
  "stability": "MEDIUM",
  "claim_type": "QUANTITATIVE",
  "config_hash": "sha256:86768038080b8ab5233f1e4b7aba10af05b5bb44caa432095150b90e81209809",
  "probability": "0.8581",
  "provisional": true,
  "evidence_sum": "1.800000",
  "snapshot_seq": 25409,
  "prior_log_odds": "0.000000",
  "support_groups": 1,
  "model_dependent": false,
  "review_coverage": "0.25",
  "truth_evaluable": true,
  "assessment_state": "SUPPORTED",
  "review_checklist": {
    "qualifiers_reviewed": {
      "by": [],
      "ok": false
    },
    "opposing_search_done": {
      "by": [],
      "ok": false
    },
    "independence_reviewed": {
      "by": [],
      "ok": false
    },
    "primary_source_reviewed": {
      "by": [
        "19702a28-68af-86ac-81f2-da903118398c",
        "6a8bb547-e0a0-87d2-ac5e-4756f9857499",
        "c311d57b-94de-810b-a066-86311e10608f"
      ],
      "ok": true
    }
  },
  "contradict_groups": 0,
  "rounding_boundary": false,
  "posterior_log_odds": "1.800000",
  "not_applicable_reason": null,
  "independence_unreviewed": 3
}