Claim

GPN-Star is a phylogeny-aware genomic language model that uses whole-genome alignments and species trees to model evolutionary relationships.

Type DEFINITIONAL · truth-evaluable: yes · status at snapshot: ACTIVE · created seq 22381

a conjunction joins clauses that may be separately evaluable

Referenced 123 times: checked 2, looked up by assistants 0, viewed 72, shared 49. A count of attention, not evidence.

Topics

Biology · 1efd24fe AI · 1efd24fe

Assessment

Supported

Score: 0.9734 under ledger-default@0.3.0 at snapshot 27745

2 of 4 review checks done · 1 counted · 1 by the author only

2 independent evidence lineages · review checks 1 of 4 · stability HIGH

Main unresolved issue: 3 counted evidence items have no independence review; repeats of one origin may be counted as several coverage:f50dd4be-3f6c-8218-a30a-b087101ba6f4

Not yet independently audited.Evidence reviewed so far supports this claim, but only 1 of 4 review checks has been done.A quoted passage from nature.com was not found on the page when Galedra fetched it.

Why?

Strongest counted support: The main text describes GPN-Star’s transformer architecture as integrating sequence context with evolutionary information from multispecies alignments. weight 1.800000 evidence

Suppressed as dependent: The passage directly defines GPN-Star as a phylogeny-aware genomic language model using whole-genome alignments and species trees.

Review gaps: qualifiers reviewed, opposing search done, independence reviewed

What would most change this: One independent, direct measurement that contradicts this claim would move it from Supported to Supported.

Hide calculation

0.9734 under ledger-default@0.3.0 at snapshot 27745 · state Supported · Review checks: 1 of 4 · stability HIGH · 3 sources, 2 independent lineages

Model ledger-default@0.3.0 (the default model, not the answer) · snapshot 27745 · trace sha256:7c677dd9b63727b86e4b4da0b24f24797cc5b7b1dfac603293156bdf8e6f0a74

Last changed at entry seq 25643; nothing logged since has borne on this claim.

How the number was reached

Each counted link is weighed by multiplying the factors the model declares; a factor it does not declare is not shown. Every factor name below links to what that number means.

Link	Working	Weight	Counted as
896ae688 support	relevance DIRECT 2.0 × observation DIRECT_TEXT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.800000	1.800000
9eae6449 support	relevance DIRECT 2.0 × observation DIRECT_TEXT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.800000	1.800000
109c5930 support	relevance DIRECT 2.0 × observation DIRECT_TEXT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.800000	0.000000 (dependent strongest only, kept 9eae6449)

prior 0.50 → log-odds 0.000000 + 3.600000 (the counted weights) = 3.600000 → probability 0.9734

Under neighbouring settings of the same model: 0.9255 to 0.9908, a spread of 0.0653.

Half-even rounding, six places for weights and four for the probability. The same inputs under the same model reproduce this exactly; that is what the trace hash above is for. How a score is worked out explains every factor, why it is there, and what the model sets it to.

Your view

Registered views

Nobody has registered a view yet.

Registered views are personal belief, not evidence: they never change Galedra's assessment. Affiliations are self-declared and shown only for groups of 5 or more.

Checked as part of

Statements this claim was broken out of. The claim is scored on its own; a statement's reading only counts its claims.

“GPN-Star is a phylogeny-aware genomic language model that uses whole-genome alignments and species trees to model evolutionary relationships.” · 1 claim · 29 September 2026
“The Nature study introduced GPN-Star, a phylogeny-aware genomic language model for predicting genome-wide functional constraints and variant effects.” · 3 claims · 29 September 2026

Evidence for

The primary abstract defines GPN-Star as a phylogeny-aware model using whole-genome alignments and species trees.

From Predicting genome-wide functional constraints with GPN-Star Read 2026-09-29 Relevance DIRECT Steps 0 Counted

Exact abstract definition.
The main text describes GPN-Star’s transformer architecture as integrating sequence context with evolutionary information from multispecies alignments.

From Predicting genome-wide functional constraints with GPN-Star Read 2026-09-29 Relevance DIRECT Steps 0 Counted

Additional primary-text architecture description.
The passage directly defines GPN-Star as a phylogeny-aware genomic language model using whole-genome alignments and species trees.

From Predicting genome-wide functional constraints with GPN-Star Read 2026-09-29 Relevance DIRECT Steps 0 Counted

Evidence against

None.

Qualifications

None.

Suppressed as dependent

Evidence	Group	Kept instead
268a8601		9eae6449

Inferences

Concluded from

None.

Used as a premise in

None.

An inference is interpretation, not evidence: it never changes the assessment of its conclusion. Each premise is a claim with its own evidence.

Threads

None. Threads are for disagreements about how a determination was made — a statement whose figures are not in the passage it rests on, two sources that may share an origin. Something about the world belongs in the evidence above.

Claim edges

None. Edges are stored and displayed; v0.1 does not propagate probability across them.

Review checklist

Review checks: 1 of 4

2 checks by this claim's own author, alongside the independent review above. 1 QUALIFIER CHECK · 1 EVIDENCE VERIFICATION. A check by the person who recorded a claim does not raise its review coverage.

Check	Done	By
qualifiers reviewed	no
opposing search done	no
independence reviewed	no
primary source reviewed	yes	896ae688, 9eae6449, 109c5930

Summary

Supported. The main support is: The main text describes GPN-Star’s transformer architecture as integrating sequence context with evolutionary information from multispecies alignments. dbeecd27

1 further item repeats the same origin and is not independent evidence. 268a8601

Review checks: 1 of 4. coverage:f50dd4be-3f6c-8218-a30a-b087101ba6f4

Generated by stub-v0.1; every sentence cites graph ids.

Contribution history

seq	event	detail
22381	APPENDED
22382	ACCEPT	AUTOMATIC_AFTER_VALIDATION
22399	LINK_EVIDENCE	by 1efd24fe (accepted)
22447	LINK_EVIDENCE	by 1efd24fe (accepted)
24584	TASK_RESULT	by 1efd24fe (accepted)

Score trace

{
  "claim": "f50dd4be-3f6c-8218-a30a-b087101ba6f4",
  "links": [
    {
      "link": "0a25f500-e442-8a46-a855-26e8896ae688",
      "group": null,
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "f3c2fa0c-32e1-8cbd-80da-77ccdbeecd27",
      "direction": "SUPPORT",
      "magnitude": "1.800000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "DIRECT_TEXT",
      "source_type": "PRIMARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "1.800000",
      "interpretive_steps": 0
    },
    {
      "link": "4aa03b0f-9cd7-86be-b3a6-63dc9eae6449",
      "group": null,
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "274f4630-dcf4-8dbd-b7e2-915e804268ac",
      "direction": "SUPPORT",
      "magnitude": "1.800000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "DIRECT_TEXT",
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      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "1.800000",
      "interpretive_steps": 0
    },
    {
      "kept": "4aa03b0f-9cd7-86be-b3a6-63dc9eae6449",
      "link": "f5258f9e-ba6e-86f8-b0ae-a4be109c5930",
      "group": null,
      "reason": "dependent_strongest_only",
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "5b884a6d-60ff-85a7-90b3-7da2268a8601",
      "direction": "SUPPORT",
      "magnitude": "1.800000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "DIRECT_TEXT",
      "source_type": "PRIMARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "0.000000",
      "interpretive_steps": 0
    }
  ],
  "model": "ledger-default@0.3.0",
  "prior": "0.50",
  "variants": {
    "spread": "0.0653",
    "permissive": "0.9908",
    "conservative": "0.9255"
  },
  "code_hash": "sha256:c61a6fdf35a754a0d7e958df149036a083c0eaeb7d2d2e52704ec32b0c36def7",
  "contested": false,
  "stability": "HIGH",
  "claim_type": "DEFINITIONAL",
  "config_hash": "sha256:86768038080b8ab5233f1e4b7aba10af05b5bb44caa432095150b90e81209809",
  "probability": "0.9734",
  "provisional": true,
  "evidence_sum": "3.600000",
  "snapshot_seq": 25643,
  "prior_log_odds": "0.000000",
  "support_groups": 2,
  "model_dependent": false,
  "review_coverage": "0.25",
  "truth_evaluable": true,
  "assessment_state": "SUPPORTED",
  "review_checklist": {
    "qualifiers_reviewed": {
      "by": [],
      "ok": false
    },
    "opposing_search_done": {
      "by": [],
      "ok": false
    },
    "independence_reviewed": {
      "by": [],
      "ok": false
    },
    "primary_source_reviewed": {
      "by": [
        "0a25f500-e442-8a46-a855-26e8896ae688",
        "4aa03b0f-9cd7-86be-b3a6-63dc9eae6449",
        "f5258f9e-ba6e-86f8-b0ae-a4be109c5930"
      ],
      "ok": true
    }
  },
  "contradict_groups": 0,
  "rounding_boundary": false,
  "posterior_log_odds": "3.600000",
  "not_applicable_reason": null,
  "independence_unreviewed": 3
}