Evidence item

eGene detection depends on cell-type abundance, and subclass resolution can reduce power because of smaller subclass sample sizes. DIRECT_TEXT

Authenticity UNVERIFIED · extraction UNVERIFIED · independence group none (unreviewed) · created seq 25461

Source: Single-nucleus atlas of cell-type specific genetic regulation in the human brain · locator {} · excerpt hash sha256:f43b3c919685a49218de89ccbedf1ac17d4e61fe4fb7d2caec6b99d571347e23

The number of detected eGenes increases with cell type abundance... Further stratification into 27 cell subclasses enhances cellular resolution but often reduces statistical power relative to class-level analyses because of decreased sample sizes within each subclass.