Claim

Model ledger-default@0.1.0 ledger-strict@0.1.0 ledger-default@0.2.0 ledger-strict@0.2.0 ledger-default@0.3.0 (default) ledger-strict@0.3.0 Snapshot seq

Topics

Neuroscience · 1efd24fe Biology · 1efd24fe

Assessment

Why?

Strongest counted support: The primary atlas reports 5.6 million nuclei, 1,384 donors, and regulatory signals for 14,258 genes across multiple cell resolutions. weight 1.800000 evidence

Suppressed as dependent: The quoted passage directly reports 5.6 million nuclei, 1,384 donors, 14,258 genes, eight cell classes, and 27 subclasses.

Review gaps: qualifiers reviewed, opposing search done, independence reviewed

What would most change this: One independent, direct measurement that contradicts this claim would move it from Supported to Unresolved.

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Checked as part of

Statements this claim was broken out of. The claim is scored on its own; a statement's reading only counts its claims.

• “A 2026 Nature Genetics study built a multi-ancestry single-nucleus atlas of human prefrontal-cortex genetic regulation and identified cell-type-specific...” · 2 claims · 29 September 2026

Evidence for

• The primary atlas reports 5.6 million nuclei, 1,384 donors, and regulatory signals for 14,258 genes across multiple cell resolutions.

  From Single-nucleus atlas of cell-type specific genetic regulation in the human brain Read 2026-09-29 Relevance DIRECT Steps 0 Counted

  Primary multi-ancestry single-nucleus atlas.

• The quoted passage directly reports 5.6 million nuclei, 1,384 donors, 14,258 genes, eight cell classes, and 27 subclasses.

  From Single-nucleus atlas of cell-type specific genetic regulation in the human brain Read 2026-09-29 Relevance DIRECT Steps 0 Counted

  The excerpt states every quantitative component of the claim.

Evidence against

None.

Qualifications

• The dataset is postmortem human dorsolateral prefrontal cortex, with 5.6 million nuclei from 1,384 diverse-ancestry donors and 35.6% non-European ancestry.

  From Single-nucleus atlas of cell-type specific genetic regulation in the human brain Read 2026-09-29 Relevance DIRECT Steps 0 Counted

  Specifies the exact brain region, postmortem sampling, donor count, and ancestry proportion.

• The analyzed 1,384 donors are the QC-passing subset of 1,494 DLPFC donors initially obtained.

  From Single-nucleus atlas of cell-type specific genetic regulation in the human brain Read 2026-09-29 Relevance DIRECT Steps 0 Counted

  Distinguishes initially obtained donors from the QC-passing analyzed denominator.

• eGene detection depends on cell-type abundance, and subclass resolution can reduce power because of smaller subclass sample sizes.

  From Single-nucleus atlas of cell-type specific genetic regulation in the human brain Read 2026-09-29 Relevance DIRECT Steps 0 Counted

  Limits interpretation of gene-regulation counts across cell classes and subclasses.

• The donor cohort spans the full postnatal age range from 0 to 108 years with similar male and female counts.

  From Single-nucleus atlas of cell-type specific genetic regulation in the human brain Read 2026-09-29 Relevance DIRECT Steps 0 Counted

  Adds the donor age range and sex-balance context.

Suppressed as dependent

Evidence	Group	Kept instead
51441156		b08d7cbb

Inferences

Concluded from

None.

Used as a premise in

None.

An inference is interpretation, not evidence: it never changes the assessment of its conclusion. Each premise is a claim with its own evidence.

Threads

None. Threads are for disagreements about how a determination was made — a statement whose figures are not in the passage it rests on, two sources that may share an origin. Something about the world belongs in the evidence above.

Claim edges

From	Relationship	To
4e15ee2a	NARROWS	ddba5235

Review checklist

Review checks: 1 of 4

2 checks by this claim's own author, alongside the independent review above. 1 QUALIFIER CHECK · 1 EVIDENCE VERIFICATION. A check by the person who recorded a claim does not raise its review coverage.

Check	Done	By
qualifiers reviewed	no
opposing search done	no
independence reviewed	no
primary source reviewed	yes	8ca39a76, e56b9961, 63aaf9b8, 7c5a2b46, 42395c22, b08d7cbb

Summary

Contribution history

seq	event	detail
18646	APPENDED
18647	ACCEPT	AUTOMATIC_AFTER_VALIDATION
18658	LINK_EVIDENCE	by 1efd24fe (accepted)
24469	TASK_RESULT	by 1efd24fe (accepted)
25461	TASK_RESULT	by 1efd24fe (accepted)