Claim

A multi-ancestry human prefrontal-cortex atlas analyzed 5.6 million nuclei from 1,384 donors and identified genetic regulation for 14,258 genes across eight cell classes and 27 subclasses.

Type QUANTITATIVE · truth-evaluable: yes · status at snapshot: ACTIVE · created seq 18646

26 words; atomic claims are usually under 25a conjunction joins clauses that may be separately evaluablea comma-separated series may list several propositions

Referenced 131 times: checked 1, looked up by assistants 1, viewed 111, shared 18. A count of attention, not evidence.

Topics

Neuroscience · 1efd24fe Biology · 1efd24fe

Assessment

Supported

Score: 0.8581 under ledger-default@0.3.0 at snapshot 27745

2 of 4 review checks done · 1 counted · 1 by the author only

1 independent evidence lineage · review checks 1 of 4 · stability MEDIUM

Main unresolved issue: 6 counted evidence items have no independence review; repeats of one origin may be counted as several coverage:fcaf50f5-e520-8368-8686-6911ddba5235

Not yet independently audited.Evidence reviewed so far supports this claim, but only 1 of 4 review checks has been done.Every quoted passage was confirmed on the page when Galedra fetched it.

Related: NARROWS incoming: Supported

Why?

Strongest counted support: The primary atlas reports 5.6 million nuclei, 1,384 donors, and regulatory signals for 14,258 genes across multiple cell resolutions. weight 1.800000 evidence

Suppressed as dependent: The quoted passage directly reports 5.6 million nuclei, 1,384 donors, 14,258 genes, eight cell classes, and 27 subclasses.

Review gaps: qualifiers reviewed, opposing search done, independence reviewed

What would most change this: One independent, direct measurement that contradicts this claim would move it from Supported to Unresolved.

Hide calculation

0.8581 under ledger-default@0.3.0 at snapshot 27745 · state Supported · Review checks: 1 of 4 · stability MEDIUM · 6 sources, 1 independent lineage

Model ledger-default@0.3.0 (the default model, not the answer) · snapshot 27745 · trace sha256:1f907867b8ce667ba5f0d12ddf623ced681c4bfb780224be15f60c515d0f4ce8

Last changed at entry seq 25462; nothing logged since has borne on this claim.

How the number was reached

Each counted link is weighed by multiplying the factors the model declares; a factor it does not declare is not shown. Every factor name below links to what that number means.

Link	Working	Weight	Counted as
8ca39a76 qualify	relevance DIRECT 2.0 × observation DATASET_RESULT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.800000	0.000000 (non directional)
e56b9961 qualify	relevance DIRECT 2.0 × observation DATASET_RESULT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.800000	0.000000 (non directional)
63aaf9b8 qualify	relevance DIRECT 2.0 × observation DATASET_RESULT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.800000	0.000000 (non directional)
7c5a2b46 support	relevance DIRECT 2.0 × observation DIRECT_TEXT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.800000	0.000000 (dependent strongest only, kept b08d7cbb)
42395c22 qualify	relevance DIRECT 2.0 × observation DIRECT_TEXT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.800000	0.000000 (non directional)
b08d7cbb support	relevance DIRECT 2.0 × observation DATASET_RESULT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.800000	1.800000

prior 0.50 → log-odds 0.000000 + 1.800000 (the counted weights) = 1.800000 → probability 0.8581

Under neighbouring settings of the same model: 0.7790 to 0.9121, a spread of 0.1331.

Half-even rounding, six places for weights and four for the probability. The same inputs under the same model reproduce this exactly; that is what the trace hash above is for. How a score is worked out explains every factor, why it is there, and what the model sets it to.

Your view

Registered views

Nobody has registered a view yet.

Registered views are personal belief, not evidence: they never change Galedra's assessment. Affiliations are self-declared and shown only for groups of 5 or more.

Checked as part of

Statements this claim was broken out of. The claim is scored on its own; a statement's reading only counts its claims.

“A 2026 Nature Genetics study built a multi-ancestry single-nucleus atlas of human prefrontal-cortex genetic regulation and identified cell-type-specific...” · 2 claims · 29 September 2026

Evidence for

The primary atlas reports 5.6 million nuclei, 1,384 donors, and regulatory signals for 14,258 genes across multiple cell resolutions.

From Single-nucleus atlas of cell-type specific genetic regulation in the human brain Read 2026-09-29 Relevance DIRECT Steps 0 Counted

Primary multi-ancestry single-nucleus atlas.
The quoted passage directly reports 5.6 million nuclei, 1,384 donors, 14,258 genes, eight cell classes, and 27 subclasses.

From Single-nucleus atlas of cell-type specific genetic regulation in the human brain Read 2026-09-29 Relevance DIRECT Steps 0 Counted

The excerpt states every quantitative component of the claim.

Evidence against

None.

Qualifications

The dataset is postmortem human dorsolateral prefrontal cortex, with 5.6 million nuclei from 1,384 diverse-ancestry donors and 35.6% non-European ancestry.

From Single-nucleus atlas of cell-type specific genetic regulation in the human brain Read 2026-09-29 Relevance DIRECT Steps 0 Counted

Specifies the exact brain region, postmortem sampling, donor count, and ancestry proportion.
The analyzed 1,384 donors are the QC-passing subset of 1,494 DLPFC donors initially obtained.

From Single-nucleus atlas of cell-type specific genetic regulation in the human brain Read 2026-09-29 Relevance DIRECT Steps 0 Counted

Distinguishes initially obtained donors from the QC-passing analyzed denominator.
eGene detection depends on cell-type abundance, and subclass resolution can reduce power because of smaller subclass sample sizes.

From Single-nucleus atlas of cell-type specific genetic regulation in the human brain Read 2026-09-29 Relevance DIRECT Steps 0 Counted

Limits interpretation of gene-regulation counts across cell classes and subclasses.
The donor cohort spans the full postnatal age range from 0 to 108 years with similar male and female counts.

From Single-nucleus atlas of cell-type specific genetic regulation in the human brain Read 2026-09-29 Relevance DIRECT Steps 0 Counted

Adds the donor age range and sex-balance context.

Suppressed as dependent

Evidence	Group	Kept instead
51441156		b08d7cbb

Inferences

Concluded from

None.

Used as a premise in

None.

An inference is interpretation, not evidence: it never changes the assessment of its conclusion. Each premise is a claim with its own evidence.

Threads

None. Threads are for disagreements about how a determination was made — a statement whose figures are not in the passage it rests on, two sources that may share an origin. Something about the world belongs in the evidence above.

Claim edges

From	Relationship	To
4e15ee2a	NARROWS	ddba5235

Review checklist

Review checks: 1 of 4

2 checks by this claim's own author, alongside the independent review above. 1 QUALIFIER CHECK · 1 EVIDENCE VERIFICATION. A check by the person who recorded a claim does not raise its review coverage.

Check	Done	By
qualifiers reviewed	no
opposing search done	no
independence reviewed	no
primary source reviewed	yes	8ca39a76, e56b9961, 63aaf9b8, 7c5a2b46, 42395c22, b08d7cbb

Summary

Supported. The main support is: The primary atlas reports 5.6 million nuclei, 1,384 donors, and regulatory signals for 14,258 genes across multiple cell resolutions. e8b9fe31

1 further item repeats the same origin and is not independent evidence. 51441156

Qualifier: The dataset is postmortem human dorsolateral prefrontal cortex, with 5.6 million nuclei from 1,384 diverse-ancestry donors and 35.6% non-European ancestry. 7f7f5749

Qualifier: The analyzed 1,384 donors are the QC-passing subset of 1,494 DLPFC donors initially obtained. c5c92afa

Qualifier: The donor cohort spans the full postnatal age range from 0 to 108 years with similar male and female counts. c30d0a57

Qualifier: eGene detection depends on cell-type abundance, and subclass resolution can reduce power because of smaller subclass sample sizes. ef04bf64

Generated by stub-v0.1; every sentence cites graph ids.

Contribution history

seq	event	detail
18646	APPENDED
18647	ACCEPT	AUTOMATIC_AFTER_VALIDATION
18658	LINK_EVIDENCE	by 1efd24fe (accepted)
24469	TASK_RESULT	by 1efd24fe (accepted)
25461	TASK_RESULT	by 1efd24fe (accepted)

Score trace

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