Claim

Model ledger-default@0.1.0 ledger-strict@0.1.0 ledger-default@0.2.0 ledger-strict@0.2.0 ledger-default@0.3.0 (default) ledger-strict@0.3.0 Snapshot seq

Topics

Biology · 1efd24fe Neuroscience · 1efd24fe

Assessment

Why?

Strongest counted support: The abstract says the data support a yolk-sac origin for meningeal myeloid lineages, including perivascular macrophages. weight 1.800000 evidence

Suppressed as dependent: The excerpt directly states that the atlas supports yolk-sac origin for meningeal myeloid lineages, including perivascular macrophages primed for barrier immunity.

Review gaps: qualifiers reviewed, opposing search done, independence reviewed

What would most change this: One independent, direct measurement that contradicts this claim would move it from Supported to Unresolved.

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Checked as part of

Statements this claim was broken out of. The claim is scored on its own; a statement's reading only counts its claims.

• “A spatially resolved multiomic atlas of human meningeal development maps developmental cell states, regulatory programs, and disease-associated signaling...” · 3 claims · 29 September 2026

Evidence for

• The abstract says the data support a yolk-sac origin for meningeal myeloid lineages, including perivascular macrophages.

  From Spatially resolved multiomics of human meningeal development reveal lineage and disease dynamics Read 2026-09-29 Relevance DIRECT Steps 0 Counted

• The excerpt directly states that the atlas supports yolk-sac origin for meningeal myeloid lineages, including perivascular macrophages primed for barrier immunity.

  From Spatially resolved multiomics of human meningeal development reveal lineage and disease dynamics Read 2026-09-29 Relevance DIRECT Steps 0 Counted

Evidence against

None.

Qualifications

• The dataset abstract limits the atlas to human cranial meninges at 6–21 post-conception weeks and phrases yolk-sac origin as support from multiomic data.

  From Spatially resolved multiomics of human meninges development reveal lineage and disease dynamics – AnnData objects Read 2026-09-29 Relevance DIRECT Steps 0 Counted

  Limits developmental window and distinguishes atlas-based support from direct lineage tracing.

Suppressed as dependent

Evidence	Group	Kept instead
2ae3c741		be431e79

Inferences

Concluded from

None.

Used as a premise in

None.

An inference is interpretation, not evidence: it never changes the assessment of its conclusion. Each premise is a claim with its own evidence.

Threads

None. Threads are for disagreements about how a determination was made — a statement whose figures are not in the passage it rests on, two sources that may share an origin. Something about the world belongs in the evidence above.

Claim edges

From	Relationship	To
aed2f1d4	NARROWS	def9e18a

Review checklist

Review checks: 1 of 4

2 checks by this claim's own author, alongside the independent review above. 1 QUALIFIER CHECK · 1 EVIDENCE VERIFICATION. A check by the person who recorded a claim does not raise its review coverage.

Check	Done	By
qualifiers reviewed	no
opposing search done	no
independence reviewed	no
primary source reviewed	yes	bbfcb539, be431e79, 7b1f3a8f

Summary

Contribution history

seq	event	detail
24148	APPENDED
24149	ACCEPT	AUTOMATIC_AFTER_VALIDATION
24164	LINK_EVIDENCE	by 1efd24fe (accepted)
24649	TASK_RESULT	by 1efd24fe (accepted)
25721	TASK_RESULT	by 1efd24fe (accepted)

Score trace

{
  "claim": "10124bc2-4dc2-89c8-9bf6-0e87def9e18a",
  "links": [
    {
      "link": "48af643f-e001-8b6e-8075-40f7bbfcb539",
      "group": null,
      "reason": "non_directional",
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "5d1ea9d4-ffa1-8427-ac12-fa151ae5ec4e",
      "direction": "QUALIFY",
      "magnitude": "1.800000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "DIRECT_TEXT",
      "source_type": "DATASET",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "0.000000",
      "interpretive_steps": 0
    },
    {
      "link": "6855c55e-6839-8df3-a039-3152be431e79",
      "group": null,
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "1d299495-4b33-877f-b502-a96693a92563",
      "direction": "SUPPORT",
      "magnitude": "1.800000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "DIRECT_TEXT",
      "source_type": "PRIMARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "1.800000",
      "interpretive_steps": 0
    },
    {
      "kept": "6855c55e-6839-8df3-a039-3152be431e79",
      "link": "a2965d12-29e7-8ca2-afd8-2fea7b1f3a8f",
      "group": null,
      "reason": "dependent_strongest_only",
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "4db4d53d-f81b-853c-8ead-9d2e2ae3c741",
      "direction": "SUPPORT",
      "magnitude": "1.800000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "DIRECT_TEXT",
      "source_type": "PRIMARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "0.000000",
      "interpretive_steps": 0
    }
  ],
  "model": "ledger-default@0.3.0",
  "prior": "0.50",
  "variants": {
    "spread": "0.1331",
    "permissive": "0.9121",
    "conservative": "0.7790"
  },
  "code_hash": "sha256:c61a6fdf35a754a0d7e958df149036a083c0eaeb7d2d2e52704ec32b0c36def7",
  "contested": false,
  "stability": "LOW",
  "claim_type": "INTERPRETIVE",
  "config_hash": "sha256:86768038080b8ab5233f1e4b7aba10af05b5bb44caa432095150b90e81209809",
  "probability": "0.8581",
  "provisional": true,
  "evidence_sum": "1.800000",
  "snapshot_seq": 25722,
  "prior_log_odds": "0.000000",
  "support_groups": 1,
  "model_dependent": true,
  "review_coverage": "0.25",
  "truth_evaluable": true,
  "assessment_state": "SUPPORTED",
  "review_checklist": {
    "qualifiers_reviewed": {
      "by": [],
      "ok": false
    },
    "opposing_search_done": {
      "by": [],
      "ok": false
    },
    "independence_reviewed": {
      "by": [],
      "ok": false
    },
    "primary_source_reviewed": {
      "by": [
        "48af643f-e001-8b6e-8075-40f7bbfcb539",
        "6855c55e-6839-8df3-a039-3152be431e79",
        "a2965d12-29e7-8ca2-afd8-2fea7b1f3a8f"
      ],
      "ok": true
    }
  },
  "contradict_groups": 0,
  "rounding_boundary": false,
  "posterior_log_odds": "1.800000",
  "not_applicable_reason": null,
  "independence_unreviewed": 3
}