Claim

In macrophage models, TRAM regulates myddosome assembly by dissociating MyD88 from the TLR–TIRAP complex, enabling maturation of receptor-free cytosolic myddosomes and downstream signaling.

Type CAUSAL · truth-evaluable: yes · status at snapshot: ACTIVE · created seq 24249 · qualifiers {"population":"Macrophage models; biochemical, live-cell, and recombinant-protein experiments"}

a comma-separated series may list several propositions

Referenced 179 times: checked 1, looked up by assistants 0, viewed 134, shared 44. A count of attention, not evidence.

Topics

Biology · 1efd24fe Medicine · 1efd24fe

Assessment

Leans supported

Score: 0.6550 under ledger-default@0.3.0 at snapshot 27745

3 of 4 review checks done · 1 counted · 2 by the author only

2 independent evidence lineages · review checks 1 of 4 · stability LOW

Main unresolved issue: 3 counted evidence items have no independence review; repeats of one origin may be counted as several coverage:1a4d891b-cc3d-8967-9e3f-d1ac94edb4c0

Not yet independently audited.Evidence points both ways.This assessment depends heavily on modeling choices.A quoted passage from nature.com was not found on the page when Galedra fetched it.

Why?

Strongest counted support: The abstract reports that TRAM dissociates MyD88 from TLR–TIRAP complexes, enabling receptor-free myddosome maturation and downstream signaling in macrophage models. weight 1.800000 evidence

Strongest counted contradiction: The authors say their data cannot resolve active displacement versus recruitment kinetics, competitive binding, or membrane-environment changes. weight 0.540000 evidence

Suppressed as dependent: The excerpt directly reports in macrophages that TRAM dissociates MyD88 from the TLR–TIRAP complex, enabling receptor-free myddosome maturation and downstream signaling.

Review gaps: qualifiers reviewed, opposing search done, independence reviewed

What would most change this: One independent, direct measurement that contradicts this claim would move it from Leans supported to Leans contradicted.

Hide calculation

0.6550 under ledger-default@0.3.0 at snapshot 27745 · state Leans supported · Review checks: 1 of 4 · stability LOW · 3 sources, 2 independent lineages

Model ledger-default@0.3.0 (the default model, not the answer) · snapshot 27745 · trace sha256:d40872ffe1cdabb33b74a88909f032e18289bdb41828f79a9344a4cb51981776

Last changed at entry seq 25249; nothing logged since has borne on this claim.

How the number was reached

Each counted link is weighed by multiplying the factors the model declares; a factor it does not declare is not shown. Every factor name below links to what that number means.

Link	Working	Weight	Counted as
4e7c99b4 contradict	relevance MODERATE 0.6 × observation DIRECT_TEXT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	0.540000	0.540000
f43cdf1f support	relevance DIRECT 2.0 × observation DIRECT_TEXT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.800000	0.000000 (dependent strongest only, kept f388e6ee)
f388e6ee support	relevance DIRECT 2.0 × observation DIRECT_TEXT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.800000	1.800000

prior 0.35 → log-odds -0.619039 + 1.260000 (the counted weights) = 0.640961 → probability 0.6550

Under neighbouring settings of the same model: 0.5654 to 0.7348, a spread of 0.1694.

Half-even rounding, six places for weights and four for the probability. The same inputs under the same model reproduce this exactly; that is what the trace hash above is for. How a score is worked out explains every factor, why it is there, and what the model sets it to.

Your view

Registered views

Nobody has registered a view yet.

Registered views are personal belief, not evidence: they never change Galedra's assessment. Affiliations are self-declared and shown only for groups of 5 or more.

Checked as part of

Statements this claim was broken out of. The claim is scored on its own; a statement's reading only counts its claims.

“A Nature study identifies TRAM as a regulator of receptor-free myddosome maturation and sustained Toll-like-receptor signaling in macrophage models.” · 3 claims · 29 September 2026

Evidence for

The abstract reports that TRAM dissociates MyD88 from TLR–TIRAP complexes, enabling receptor-free myddosome maturation and downstream signaling in macrophage models.

From TRAM promotes Toll-like-receptor-free myddosome signal transduction Read 2026-09-29 Relevance DIRECT Steps 0 Counted
The excerpt directly reports in macrophages that TRAM dissociates MyD88 from the TLR–TIRAP complex, enabling receptor-free myddosome maturation and downstream signaling.

From TRAM promotes Toll-like-receptor-free myddosome signal transduction Read 2026-09-29 Relevance DIRECT Steps 0 Counted

The passage exactly matches the macrophage model, dissociation mechanism, maturation, and signaling components.

Evidence against

The authors say their data cannot resolve active displacement versus recruitment kinetics, competitive binding, or membrane-environment changes.

From TRAM promotes Toll-like receptor-free myddosome signal transduction: supplementary reviewer response Read 2026-09-29 Relevance MODERATE Steps 0 Counted

The primary study leaves the exact TRAM-mediated dissociation mechanism unresolved.

Qualifications

None.

Suppressed as dependent

Evidence	Group	Kept instead
900c3361		f388e6ee

Inferences

Concluded from

None.

Used as a premise in

None.

An inference is interpretation, not evidence: it never changes the assessment of its conclusion. Each premise is a claim with its own evidence.

Threads

None. Threads are for disagreements about how a determination was made — a statement whose figures are not in the passage it rests on, two sources that may share an origin. Something about the world belongs in the evidence above.

Claim edges

None. Edges are stored and displayed; v0.1 does not propagate probability across them.

Review checklist

Review checks: 1 of 4

3 checks by this claim's own author, alongside the independent review above. 1 OPPOSING EVIDENCE SEARCH · 1 QUALIFIER CHECK · 1 EVIDENCE VERIFICATION. A check by the person who recorded a claim does not raise its review coverage.

Check	Done	By
qualifiers reviewed	no
opposing search done	no
independence reviewed	no
primary source reviewed	yes	4e7c99b4, f43cdf1f, f388e6ee

Summary

Leans supported. The main support is: The abstract reports that TRAM dissociates MyD88 from TLR–TIRAP complexes, enabling receptor-free myddosome maturation and downstream signaling in macrophage models. 97a20d4d

Against that, contradiction: The authors say their data cannot resolve active displacement versus recruitment kinetics, competitive binding, or membrane-environment changes. ba4e12c0

1 further item repeats the same origin and is not independent evidence. 900c3361

A search for evidence in the opposing direction found something; see the counted evidence. 1a27daf2

Review checks: 1 of 4. coverage:1a4d891b-cc3d-8967-9e3f-d1ac94edb4c0

Generated by stub-v0.1; every sentence cites graph ids.

Contribution history

seq	event	detail
24249	APPENDED
24250	ACCEPT	AUTOMATIC_AFTER_VALIDATION
24267	LINK_EVIDENCE	by 1efd24fe (accepted)
24276	TASK_RESULT	by 1efd24fe (accepted)
25248	TASK_RESULT	by 1efd24fe (accepted)

Score trace

{
  "claim": "1a4d891b-cc3d-8967-9e3f-d1ac94edb4c0",
  "links": [
    {
      "link": "0a5042f1-f40a-89d1-91df-ff424e7c99b4",
      "group": null,
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "2d3e134d-eac5-8dd4-a450-5eaeba4e12c0",
      "direction": "CONTRADICT",
      "magnitude": "0.540000",
      "relevance": "MODERATE",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "DIRECT_TEXT",
      "source_type": "PRIMARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "0.540000",
      "interpretive_steps": 0
    },
    {
      "kept": "f7ecb47e-0c63-890c-ba43-88aaf388e6ee",
      "link": "1b94c052-9d8d-89c7-8fb3-3bcdf43cdf1f",
      "group": null,
      "reason": "dependent_strongest_only",
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "4534e9ab-94fe-8e3e-8d18-08b3900c3361",
      "direction": "SUPPORT",
      "magnitude": "1.800000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "DIRECT_TEXT",
      "source_type": "PRIMARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "0.000000",
      "interpretive_steps": 0
    },
    {
      "link": "f7ecb47e-0c63-890c-ba43-88aaf388e6ee",
      "group": null,
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "63be181d-838a-8075-8023-00b297a20d4d",
      "direction": "SUPPORT",
      "magnitude": "1.800000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "DIRECT_TEXT",
      "source_type": "PRIMARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "1.800000",
      "interpretive_steps": 0
    }
  ],
  "model": "ledger-default@0.3.0",
  "prior": "0.35",
  "variants": {
    "spread": "0.1694",
    "permissive": "0.7348",
    "conservative": "0.5654"
  },
  "code_hash": "sha256:c61a6fdf35a754a0d7e958df149036a083c0eaeb7d2d2e52704ec32b0c36def7",
  "contested": true,
  "stability": "LOW",
  "claim_type": "CAUSAL",
  "config_hash": "sha256:86768038080b8ab5233f1e4b7aba10af05b5bb44caa432095150b90e81209809",
  "probability": "0.6550",
  "provisional": true,
  "evidence_sum": "1.260000",
  "snapshot_seq": 25249,
  "prior_log_odds": "-0.619039",
  "support_groups": 1,
  "model_dependent": true,
  "review_coverage": "0.25",
  "truth_evaluable": true,
  "assessment_state": "LEANS_SUPPORTED",
  "review_checklist": {
    "qualifiers_reviewed": {
      "by": [],
      "ok": false
    },
    "opposing_search_done": {
      "by": [],
      "ok": false
    },
    "independence_reviewed": {
      "by": [],
      "ok": false
    },
    "primary_source_reviewed": {
      "by": [
        "0a5042f1-f40a-89d1-91df-ff424e7c99b4",
        "1b94c052-9d8d-89c7-8fb3-3bcdf43cdf1f",
        "f7ecb47e-0c63-890c-ba43-88aaf388e6ee"
      ],
      "ok": true
    }
  },
  "contradict_groups": 1,
  "rounding_boundary": false,
  "posterior_log_odds": "0.640961",
  "not_applicable_reason": null,
  "independence_unreviewed": 3
}