Claim

Model ledger-default@0.1.0 ledger-strict@0.1.0 ledger-default@0.2.0 ledger-strict@0.2.0 ledger-default@0.3.0 (default) ledger-strict@0.3.0 Snapshot seq

Topics

Medicine · 1efd24fe Health · 1efd24fe

Assessment

Why?

Strongest counted support: The study reports lower treatment-failure risk for ARPI than taxane among IMF6-high cases with the stated confidence interval and P value. weight 2.000000 evidence

Suppressed as dependent: The excerpt directly reports the IMF6-high ARPI-versus-taxane hazard ratio, confidence interval, and P value.

Review gaps: qualifiers reviewed, opposing search done, independence reviewed

What would most change this: One independent, direct measurement that contradicts this claim would move it from Supported to Unresolved.

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Checked as part of

Statements this claim was broken out of. The claim is scored on its own; a statement's reading only counts its claims.

• “In a retrospective metastatic prostate-cancer cohort, among cases classified as IMF6-high, androgen-receptor pathway inhibitor treatment was associated with...” · 1 claim · 29 September 2026
• “A 2026 Nature study integrated mutational signatures across prostate-cancer genomes to characterize mutational processes and explore clinical associations.” · 2 claims · 29 September 2026

Evidence for

• The study reports lower treatment-failure risk for ARPI than taxane among IMF6-high cases with the stated confidence interval and P value.

  From Integrated signatures define mutational processes in prostate cancer Read 2026-09-29 Relevance DIRECT Steps 0 Counted

  The passage directly reports the treatment comparison and effect estimate.

• The excerpt directly reports the IMF6-high ARPI-versus-taxane hazard ratio, confidence interval, and P value.

  From Integrated signatures define mutational processes in prostate cancer Read 2026-09-29 Relevance DIRECT Steps 0 Counted

  The passage explicitly states the treatment comparison and effect estimate.

Evidence against

None.

Qualifications

• The treatment association was evaluated in second-line metastatic castration-resistant disease, with pre-enrolment records less complete and no overall TTF difference between therapies.

  From Integrated signatures define mutational processes in prostate cancer Read 2026-09-29 Relevance DIRECT Steps 0 Counted

  Narrows the association to the study's second-line mCRPC setting and notes treatment-history and comparison limitations.

Suppressed as dependent

Evidence	Group	Kept instead
971c88a4		cc8a9f3c

Inferences

Concluded from

None.

Used as a premise in

None.

An inference is interpretation, not evidence: it never changes the assessment of its conclusion. Each premise is a claim with its own evidence.

Threads

None. Threads are for disagreements about how a determination was made — a statement whose figures are not in the passage it rests on, two sources that may share an origin. Something about the world belongs in the evidence above.

Claim edges

None. Edges are stored and displayed; v0.1 does not propagate probability across them.

Review checklist

Review checks: 1 of 4

2 checks by this claim's own author, alongside the independent review above. 1 QUALIFIER CHECK · 1 EVIDENCE VERIFICATION. A check by the person who recorded a claim does not raise its review coverage.

Check	Done	By
qualifiers reviewed	no
opposing search done	no
independence reviewed	no
primary source reviewed	yes	cc8a9f3c, 95208c8e

Summary

Contribution history

seq	event	detail
15009	APPENDED
15010	ACCEPT	AUTOMATIC_AFTER_VALIDATION
15019	LINK_EVIDENCE	by 1efd24fe (accepted)
15023	TASK_RESULT	by 1efd24fe (accepted)
15312	LINK_EVIDENCE	by 1efd24fe (accepted)

Score trace

{
  "claim": "3d5173cc-1aca-84d1-9ee1-41233f2eb2a6",
  "links": [
    {
      "link": "201ffd25-d45a-85e2-a2cc-bf72ad24d942",
      "group": null,
      "reason": "non_directional",
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "7aa4bc7b-8c3f-8167-8bcb-8fe7c4c3f722",
      "direction": "QUALIFY",
      "magnitude": "1.800000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "DIRECT_TEXT",
      "source_type": "SECONDARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "0.000000",
      "interpretive_steps": 0
    },
    {
      "link": "7b18b773-428e-8599-abc3-6a3acc8a9f3c",
      "group": null,
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "8e71d72b-210f-8525-960d-32a4af46f92c",
      "direction": "SUPPORT",
      "magnitude": "2.000000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "MEASUREMENT",
      "source_type": "PRIMARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "2.000000",
      "interpretive_steps": 0
    },
    {
      "kept": "7b18b773-428e-8599-abc3-6a3acc8a9f3c",
      "link": "fcd37bdb-a3dd-84f4-9488-e62495208c8e",
      "group": null,
      "reason": "dependent_strongest_only",
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "80d84592-cc4b-8297-b157-b700971c88a4",
      "direction": "SUPPORT",
      "magnitude": "2.000000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "MEASUREMENT",
      "source_type": "PRIMARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "0.000000",
      "interpretive_steps": 0
    }
  ],
  "model": "ledger-default@0.3.0",
  "prior": "0.50",
  "variants": {
    "spread": "0.1287",
    "permissive": "0.9309",
    "conservative": "0.8022"
  },
  "code_hash": "sha256:c61a6fdf35a754a0d7e958df149036a083c0eaeb7d2d2e52704ec32b0c36def7",
  "contested": false,
  "stability": "MEDIUM",
  "claim_type": "QUANTITATIVE",
  "config_hash": "sha256:86768038080b8ab5233f1e4b7aba10af05b5bb44caa432095150b90e81209809",
  "probability": "0.8808",
  "provisional": true,
  "evidence_sum": "2.000000",
  "snapshot_seq": 15313,
  "prior_log_odds": "0.000000",
  "support_groups": 1,
  "model_dependent": false,
  "review_coverage": "0.25",
  "truth_evaluable": true,
  "assessment_state": "SUPPORTED",
  "review_checklist": {
    "qualifiers_reviewed": {
      "by": [],
      "ok": false
    },
    "opposing_search_done": {
      "by": [],
      "ok": false
    },
    "independence_reviewed": {
      "by": [],
      "ok": false
    },
    "primary_source_reviewed": {
      "by": [
        "7b18b773-428e-8599-abc3-6a3acc8a9f3c",
        "fcd37bdb-a3dd-84f4-9488-e62495208c8e"
      ],
      "ok": true
    }
  },
  "contradict_groups": 0,
  "rounding_boundary": false,
  "posterior_log_odds": "2.000000",
  "not_applicable_reason": null,
  "independence_unreviewed": 3
}