Claim

In mouse experiments, loss of GSDMD–TMEM106A protected against lethal sepsis but weakened antibacterial defence, while overexpression had opposite effects.

Type COMPARATIVE · truth-evaluable: yes · status at snapshot: ACTIVE · created seq 21594

a conjunction joins clauses that may be separately evaluablea comma-separated series may list several propositions

Referenced 116 times: checked 2, looked up by assistants 0, viewed 76, shared 38. A count of attention, not evidence.

Topics

Biology · 1efd24fe Health · 1efd24fe

Assessment

Supported

Score: 0.8581 under ledger-default@0.3.0 at snapshot 27745

3 of 4 review checks done · 1 counted · 2 by the author only

1 independent evidence lineage · review checks 1 of 4 · stability MEDIUM

Main unresolved issue: 3 counted evidence items have no independence review; repeats of one origin may be counted as several coverage:447b2486-e4fb-8a41-a5f1-19605ee4e29f

Not yet independently audited.Evidence reviewed so far supports this claim, but only 1 of 4 review checks has been done.Every quoted passage was confirmed on the page when Galedra fetched it.

Why?

Strongest counted support: The primary Nature study reports the reciprocal sepsis and antibacterial-defence outcomes after loss or overexpression. weight 1.800000 evidence

Suppressed as dependent: The supplied passage directly reports reciprocal sepsis lethality and antibacterial-defense effects after loss or overexpression.; The primary study reports reciprocal host-defence and sepsis outcomes after loss or overexpression.

Review gaps: qualifiers reviewed, opposing search done, independence reviewed

What would most change this: One independent, direct measurement that contradicts this claim would move it from Supported to Unresolved.

Hide calculation

0.8581 under ledger-default@0.3.0 at snapshot 27745 · state Supported · Review checks: 1 of 4 · stability MEDIUM · 3 sources, 1 independent lineage

Model ledger-default@0.3.0 (the default model, not the answer) · snapshot 27745 · trace sha256:5f6eb9caf4a896f520c48b1846baa8cd559a711a9002abe81c63733e9b01dea4

Last changed at entry seq 24972; nothing logged since has borne on this claim.

How the number was reached

Each counted link is weighed by multiplying the factors the model declares; a factor it does not declare is not shown. Every factor name below links to what that number means.

Link	Working	Weight	Counted as
2d3fb20b support	relevance DIRECT 2.0 × observation DIRECT_TEXT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.800000	0.000000 (dependent strongest only, kept 522faf7c)
6d1b8fc8 support	relevance DIRECT 2.0 × observation EXPERT_ANALYSIS 0.3 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	0.600000	0.000000 (dependent strongest only, kept 522faf7c)
522faf7c support	relevance DIRECT 2.0 × observation DIRECT_TEXT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.800000	1.800000

prior 0.50 → log-odds 0.000000 + 1.800000 (the counted weights) = 1.800000 → probability 0.8581

Under neighbouring settings of the same model: 0.7790 to 0.9121, a spread of 0.1331.

Half-even rounding, six places for weights and four for the probability. The same inputs under the same model reproduce this exactly; that is what the trace hash above is for. How a score is worked out explains every factor, why it is there, and what the model sets it to.

Your view

Registered views

Nobody has registered a view yet.

Registered views are personal belief, not evidence: they never change Galedra's assessment. Affiliations are self-declared and shown only for groups of 5 or more.

Checked as part of

Statements this claim was broken out of. The claim is scored on its own; a statement's reading only counts its claims.

“In mouse experiments, loss of GSDMD–TMEM106A protected against lethal sepsis but weakened antibacterial defence, while overexpression had opposite effects.” · 1 claim · 29 September 2026
“A primary Nature study investigated regulated chimeric mRNAs and their protein functions during mammalian inflammation and immunity.” · 3 claims · 29 September 2026

Evidence for

The primary study reports reciprocal host-defence and sepsis outcomes after loss or overexpression.

From Functional chimeric mRNAs encode proteins in mammalian immunity Read 2026-09-29 Relevance DIRECT Steps 0 Counted

Primary in vivo comparison.
The primary Nature study reports the reciprocal sepsis and antibacterial-defence outcomes after loss or overexpression.

From Functional chimeric mRNAs encode proteins in mammalian immunity Read 2026-09-29 Relevance DIRECT Steps 0 Counted

Independent attachment of the exact primary-study result.
The supplied passage directly reports reciprocal sepsis lethality and antibacterial-defense effects after loss or overexpression.

From Functional chimeric mRNAs encode proteins in mammalian immunity Read 2026-09-29 Relevance DIRECT Steps 0 Counted

The excerpt states both perturbations and their opposing outcomes.

Evidence against

None.

Qualifications

None.

Suppressed as dependent

Evidence	Group	Kept instead
dc701fc4		522faf7c
6a34d157		522faf7c

Inferences

Concluded from

None.

Used as a premise in

None.

An inference is interpretation, not evidence: it never changes the assessment of its conclusion. Each premise is a claim with its own evidence.

Threads

None. Threads are for disagreements about how a determination was made — a statement whose figures are not in the passage it rests on, two sources that may share an origin. Something about the world belongs in the evidence above.

Claim edges

None. Edges are stored and displayed; v0.1 does not propagate probability across them.

Review checklist

Review checks: 1 of 4

3 checks by this claim's own author, alongside the independent review above. 1 OPPOSING EVIDENCE SEARCH · 1 QUALIFIER CHECK · 1 EVIDENCE VERIFICATION. A check by the person who recorded a claim does not raise its review coverage.

Check	Done	By
qualifiers reviewed	no
opposing search done	no
independence reviewed	no
primary source reviewed	yes	2d3fb20b, 6d1b8fc8, 522faf7c

Summary

Supported. The main support is: The primary Nature study reports the reciprocal sepsis and antibacterial-defence outcomes after loss or overexpression. 8987dfcd

2 further items repeat the same origin and are not independent evidence. dc701fc46a34d157

A search for evidence in the opposing direction found none. 067e0ecc

Review checks: 1 of 4. coverage:447b2486-e4fb-8a41-a5f1-19605ee4e29f

Generated by stub-v0.1; every sentence cites graph ids.

Contribution history

seq	event	detail
21594	APPENDED
21595	ACCEPT	AUTOMATIC_AFTER_VALIDATION
21608	LINK_EVIDENCE	by 1efd24fe (accepted)
21638	LINK_EVIDENCE	by 1efd24fe (accepted)
22322	TASK_RESULT	by 1efd24fe (accepted)

Score trace

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  "claim": "447b2486-e4fb-8a41-a5f1-19605ee4e29f",
  "links": [
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      "kept": "d53508e9-2557-8701-a8a3-5d0a522faf7c",
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      "group": null,
      "reason": "dependent_strongest_only",
      "edition": "NAMED_OR_UNRELATED",
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      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
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      "source_type": "PRIMARY_TEXT",
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      "audit_confirmed": false,
      "effective_weight": "0.000000",
      "interpretive_steps": 0
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      "group": null,
      "reason": "dependent_strongest_only",
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      "direction": "SUPPORT",
      "magnitude": "0.600000",
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      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "EXPERT_ANALYSIS",
      "source_type": "PRIMARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "0.000000",
      "interpretive_steps": 0
    },
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      "link": "d53508e9-2557-8701-a8a3-5d0a522faf7c",
      "group": null,
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "096f705d-9cda-8140-a5ca-49408987dfcd",
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      "magnitude": "1.800000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "DIRECT_TEXT",
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  "model": "ledger-default@0.3.0",
  "prior": "0.50",
  "variants": {
    "spread": "0.1331",
    "permissive": "0.9121",
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  },
  "code_hash": "sha256:c61a6fdf35a754a0d7e958df149036a083c0eaeb7d2d2e52704ec32b0c36def7",
  "contested": false,
  "stability": "MEDIUM",
  "claim_type": "COMPARATIVE",
  "config_hash": "sha256:86768038080b8ab5233f1e4b7aba10af05b5bb44caa432095150b90e81209809",
  "probability": "0.8581",
  "provisional": true,
  "evidence_sum": "1.800000",
  "snapshot_seq": 24972,
  "prior_log_odds": "0.000000",
  "support_groups": 1,
  "model_dependent": false,
  "review_coverage": "0.25",
  "truth_evaluable": true,
  "assessment_state": "SUPPORTED",
  "review_checklist": {
    "qualifiers_reviewed": {
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      "ok": false
    },
    "opposing_search_done": {
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      "ok": false
    },
    "independence_reviewed": {
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      "ok": false
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    "primary_source_reviewed": {
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      "ok": true
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  "contradict_groups": 0,
  "rounding_boundary": false,
  "posterior_log_odds": "1.800000",
  "not_applicable_reason": null,
  "independence_unreviewed": 3
}