Claim

In Drosophila, restricting protein intake during the larval stage promoted adult lifespan extension and durably downregulated Lsp2 expression in early adulthood.

Type CAUSAL · truth-evaluable: yes · status at snapshot: ACTIVE · created seq 14839 · qualifiers {"population":"Drosophila under the study's laboratory dietary and genetic conditions; this is not evidence of the same effect in humans."}

a conjunction joins clauses that may be separately evaluable

Referenced 123 times: checked 2, looked up by assistants 0, viewed 83, shared 38. A count of attention, not evidence.

Topics

Nutrition · 1efd24fe Biology · 1efd24fe

Assessment

Supported

Score: 0.9296 under ledger-default@0.3.0 at snapshot 27745

3 of 4 review checks done · 1 counted · 2 by the author only

3 independent evidence lineages · review checks 1 of 4 · stability LOW

Main unresolved issue: 4 counted evidence items have no independence review; repeats of one origin may be counted as several coverage:48581c4d-2b61-856a-87d9-10ace235094a

Not yet independently audited.Evidence points both ways.This assessment depends heavily on modeling choices.Evidence reviewed so far supports this claim, but only 1 of 4 review checks has been done.A quoted passage from nature.com was not found on the page when Galedra fetched it.

Why?

Strongest counted support: The abstract directly links larval protein restriction with adult lifespan and durable early-adult Lsp2 downregulation in Drosophila. weight 2.000000 evidence

Strongest counted contradiction: A study in Telostylinus angusticollis found larval protein restriction shortened adult lifespan, opposite to the Drosophila result. weight 0.600000 evidence

Suppressed as dependent: The excerpt directly reports adult lifespan promotion and durable early-adult Lsp2 downregulation after larval protein restriction.

Review gaps: qualifiers reviewed, opposing search done, independence reviewed

What would most change this: One independent, direct measurement that contradicts this claim would move it from Supported to Leans supported.

Hide calculation

0.9296 under ledger-default@0.3.0 at snapshot 27745 · state Supported · Review checks: 1 of 4 · stability LOW · 4 sources, 3 independent lineages

Model ledger-default@0.3.0 (the default model, not the answer) · snapshot 27745 · trace sha256:2e8a8412655ff6ffc82f370a2bf2c68a8a96aad7ff760c6eb89c77a6d6a67d16

Last changed at entry seq 16651; nothing logged since has borne on this claim.

How the number was reached

Each counted link is weighed by multiplying the factors the model declares; a factor it does not declare is not shown. Every factor name below links to what that number means.

Link	Working	Weight	Counted as
f74f7e25 support	relevance DIRECT 2.0 × observation MEASUREMENT 1.0 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	2.000000	2.000000
f56fb659 support	relevance DIRECT 2.0 × observation MEASUREMENT 1.0 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	2.000000	0.000000 (dependent strongest only, kept f74f7e25)
157d0cc7 contradict	relevance MODERATE 0.6 × observation MEASUREMENT 1.0 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	0.600000	0.600000
b124ab08 support	relevance DIRECT 2.0 × observation DIRECT_TEXT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.800000	1.800000

prior 0.35 → log-odds -0.619039 + 3.200000 (the counted weights) = 2.580961 → probability 0.9296

Under neighbouring settings of the same model: 0.8349 to 0.9718, a spread of 0.1369.

Half-even rounding, six places for weights and four for the probability. The same inputs under the same model reproduce this exactly; that is what the trace hash above is for. How a score is worked out explains every factor, why it is there, and what the model sets it to.

Your view

Registered views

Nobody has registered a view yet.

Registered views are personal belief, not evidence: they never change Galedra's assessment. Affiliations are self-declared and shown only for groups of 5 or more.

Checked as part of

Statements this claim was broken out of. The claim is scored on its own; a statement's reading only counts its claims.

“In Drosophila, restricting protein intake during the larval stage promoted adult lifespan extension and durably downregulated Lsp2 expression in early...” · 1 claim · 29 September 2026
“A 2026 Nature study in Drosophila linked larval protein restriction to adult lifespan through Lsp2, a storage protein associated with translational capacity.” · 2 claims · 28 September 2026

Evidence for

The abstract directly links larval protein restriction with adult lifespan and durable early-adult Lsp2 downregulation in Drosophila.

From Lsp2 links early-life diet to adult translation and lifespan in Drosophila Read 2026-09-29 Relevance DIRECT Steps 0 Counted

The abstract directly states the intervention and reported outcomes.
The excerpt directly reports adult lifespan promotion and durable early-adult Lsp2 downregulation after larval protein restriction.

From Lsp2 links early-life diet to adult translation and lifespan in Drosophila Read 2026-09-29 Relevance DIRECT Steps 0 Counted

The passage explicitly states both causal intervention outcomes in Drosophila.
The Nature study directly reports that larval protein restriction promotes adult lifespan and durably downregulates Lsp2 in early adulthood.

From Lsp2 links early-life diet to adult translation and lifespan in Drosophila Read 2026-09-29 Relevance DIRECT Steps 0 Counted

Primary research article abstract; independent line of evidence.

Evidence against

A study in Telostylinus angusticollis found larval protein restriction shortened adult lifespan, opposite to the Drosophila result.

From Dietary protein and lifespan across the metamorphic boundary: protein-restricted larvae develop into short-lived adults Read 2026-09-29 Relevance MODERATE Steps 0 Counted

The opposing study uses a different fly species, so it establishes context dependence rather than directly overturning the Drosophila finding.

Qualifications

None.

Suppressed as dependent

Evidence	Group	Kept instead
dbdd61ab		f74f7e25

Inferences

Concluded from

None.

Used as a premise in

None.

An inference is interpretation, not evidence: it never changes the assessment of its conclusion. Each premise is a claim with its own evidence.

Threads

None. Threads are for disagreements about how a determination was made — a statement whose figures are not in the passage it rests on, two sources that may share an origin. Something about the world belongs in the evidence above.

Claim edges

None. Edges are stored and displayed; v0.1 does not propagate probability across them.

Review checklist

Review checks: 1 of 4

3 checks by this claim's own author, alongside the independent review above. 1 OPPOSING EVIDENCE SEARCH · 1 QUALIFIER CHECK · 1 EVIDENCE VERIFICATION. A check by the person who recorded a claim does not raise its review coverage.

Check	Done	By
qualifiers reviewed	no
opposing search done	no
independence reviewed	no
primary source reviewed	yes	f74f7e25, f56fb659, 157d0cc7, b124ab08

Summary

Supported. The main support is: The abstract directly links larval protein restriction with adult lifespan and durable early-adult Lsp2 downregulation in Drosophila. d32ba093

Against that, contradiction: A study in Telostylinus angusticollis found larval protein restriction shortened adult lifespan, opposite to the Drosophila result. 627294fc

1 further item repeats the same origin and is not independent evidence. dbdd61ab

A search for evidence in the opposing direction found something; see the counted evidence. 9f6d699a

Review checks: 1 of 4. coverage:48581c4d-2b61-856a-87d9-10ace235094a

Generated by stub-v0.1; every sentence cites graph ids.

Contribution history

seq	event	detail
14839	APPENDED
14840	ACCEPT	AUTOMATIC_AFTER_VALIDATION
14851	LINK_EVIDENCE	by 1efd24fe (accepted)
14855	TASK_RESULT	by 1efd24fe (accepted)
14873	TASK_RESULT	by 1efd24fe (accepted)
16650	LINK_EVIDENCE	by 1efd24fe (accepted)

Score trace

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  "claim": "48581c4d-2b61-856a-87d9-10ace235094a",
  "links": [
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      "relevance": "DIRECT",
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      "provenance": "INDEPENDENT",
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      "source_type": "PRIMARY_TEXT",
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      "audit_confirmed": false,
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      "kept": "08e109f0-8fcb-8ca4-9b92-781af74f7e25",
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      "group": null,
      "reason": "dependent_strongest_only",
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "03279af8-6771-8730-bd29-b730dbdd61ab",
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      "effective_weight": "0.000000",
      "interpretive_steps": 0
    },
    {
      "link": "9d32f80b-3fdb-814d-a345-bfd1157d0cc7",
      "group": null,
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "679db9e7-466d-87ca-8e02-6b09627294fc",
      "direction": "CONTRADICT",
      "magnitude": "0.600000",
      "relevance": "MODERATE",
      "extraction": "UNVERIFIED",
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      "audit_confirmed": false,
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    },
    {
      "link": "a67cc2f6-06c1-8b31-81bc-f5b1b124ab08",
      "group": null,
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "f32c48de-d880-8bf1-8d44-07678ad6bbe8",
      "direction": "SUPPORT",
      "magnitude": "1.800000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "DIRECT_TEXT",
      "source_type": "PRIMARY_TEXT",
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      "audit_confirmed": false,
      "effective_weight": "1.800000",
      "interpretive_steps": 0
    }
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  "model": "ledger-default@0.3.0",
  "prior": "0.35",
  "variants": {
    "spread": "0.1369",
    "permissive": "0.9718",
    "conservative": "0.8349"
  },
  "code_hash": "sha256:c61a6fdf35a754a0d7e958df149036a083c0eaeb7d2d2e52704ec32b0c36def7",
  "contested": true,
  "stability": "LOW",
  "claim_type": "CAUSAL",
  "config_hash": "sha256:86768038080b8ab5233f1e4b7aba10af05b5bb44caa432095150b90e81209809",
  "probability": "0.9296",
  "provisional": true,
  "evidence_sum": "3.200000",
  "snapshot_seq": 16651,
  "prior_log_odds": "-0.619039",
  "support_groups": 2,
  "model_dependent": true,
  "review_coverage": "0.25",
  "truth_evaluable": true,
  "assessment_state": "SUPPORTED",
  "review_checklist": {
    "qualifiers_reviewed": {
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    },
    "opposing_search_done": {
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    },
    "independence_reviewed": {
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      "ok": false
    },
    "primary_source_reviewed": {
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      ],
      "ok": true
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  "contradict_groups": 1,
  "rounding_boundary": false,
  "posterior_log_odds": "2.580961",
  "not_applicable_reason": null,
  "independence_unreviewed": 4
}