Claim

In the phase II randomized RIO trial of 68 adult men living with HIV who interrupted ART, long-acting 3BNC117-LS and 10-1074-LS delayed viral rebound: median ART restart was 45.4 weeks with antibodies versus 4.6 weeks with placebo, and intact proviruses declined in the antibody arm.

Type QUANTITATIVE · truth-evaluable: yes · status at snapshot: ACTIVE · created seq 16895

45 words; atomic claims are usually under 25a conjunction joins clauses that may be separately evaluablea comma-separated series may list several propositions

Referenced 103 times: checked 2, looked up by assistants 0, viewed 71, shared 30. A count of attention, not evidence.

Topics

Medicine · 1efd24fe Biology · 1efd24fe

Assessment

Supported

Score: 0.9468 under ledger-default@0.3.0 at snapshot 27745

3 of 4 review checks done · 1 counted · 2 by the author only

2 independent evidence lineages · review checks 1 of 4 · stability HIGH

Main unresolved issue: 6 counted evidence items have no independence review; repeats of one origin may be counted as several coverage:48e36fc0-52e3-80ab-8a44-4ad71304f296

Not yet independently audited.Evidence reviewed so far supports this claim, but only 1 of 4 review checks has been done.A quoted passage from 2minutemedicine.com and nature.com was not found on the page when Galedra fetched it.

Why?

Strongest counted support: The RIO trial reported later ART restart and less early rebound in the bNAb arm than the placebo arm. weight 1.800000 evidence

Suppressed as dependent: The passage directly supports delayed rebound and the 45.4 versus 4.6 week ART-restart comparison, but it does not address intact-provirus decline.

Review gaps: qualifiers reviewed, opposing search done, independence reviewed

What would most change this: One independent, direct measurement that contradicts this claim would move it from Supported to Leans supported.

Hide calculation

0.9468 under ledger-default@0.3.0 at snapshot 27745 · state Supported · Review checks: 1 of 4 · stability HIGH · 6 sources, 2 independent lineages

Model ledger-default@0.3.0 (the default model, not the answer) · snapshot 27745 · trace sha256:ea52ddfbbf910e3d5b1786ea4a276bbfd4613c69a701d238233abdbe4bd3ffdd

Last changed at entry seq 26052; nothing logged since has borne on this claim.

How the number was reached

Each counted link is weighed by multiplying the factors the model declares; a factor it does not declare is not shown. Every factor name below links to what that number means.

Link	Working	Weight	Counted as
dd5e8884 support	relevance DIRECT 2.0 × observation DIRECT_TEXT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.800000	0.000000 (dependent strongest only, kept 75fc8f57)
4e48c5be qualify	relevance DIRECT 2.0 × observation EXPERT_ANALYSIS 0.3 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	0.600000	0.000000 (non directional)
75fc8f57 support	relevance DIRECT 2.0 × observation DATASET_RESULT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.800000	1.800000
7d6db54d qualify	relevance DIRECT 2.0 × observation DIRECT_TEXT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.800000	0.000000 (non directional)
2b7de334 support	relevance STRONG 1.2 × observation DIRECT_TEXT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.080000	1.080000
f77e294f qualify	relevance DIRECT 2.0 × observation MEASUREMENT 1.0 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	2.000000	0.000000 (non directional)

prior 0.50 → log-odds 0.000000 + 2.880000 (the counted weights) = 2.880000 → probability 0.9468

Under neighbouring settings of the same model: 0.8825 to 0.9769, a spread of 0.0944.

Half-even rounding, six places for weights and four for the probability. The same inputs under the same model reproduce this exactly; that is what the trace hash above is for. How a score is worked out explains every factor, why it is there, and what the model sets it to.

Your view

Registered views

Nobody has registered a view yet.

Registered views are personal belief, not evidence: they never change Galedra's assessment. Affiliations are self-declared and shown only for groups of 5 or more.

Checked as part of

Statements this claim was broken out of. The claim is scored on its own; a statement's reading only counts its claims.

“In the phase II randomized RIO trial of 68 adult men living with HIV who interrupted ART, long-acting 3BNC117-LS and 10-1074-LS delayed viral rebound: median...” · 1 claim · 29 September 2026
“In the phase II randomized RIO trial of 68 adult men living with HIV who interrupted ART, long-acting 3BNC117-LS and 10-1074-LS delayed viral rebound: median...” · 1 claim · 29 September 2026

Evidence for

The RIO trial reported later ART restart and less early rebound in the bNAb arm than the placebo arm.

From Broadly neutralizing antibodies in adult males living with HIV undergoing analytical treatment interruption: secondary and exploratory outcomes of the phase II randomized controlled RIO trial Read 2026-09-29 Relevance DIRECT Steps 0 Counted
Independent coverage reports the RIO antibody arm’s lower early rebound and much later median ART restart than placebo.

From Use of long-acting broadly neutralizing antibodies may delay HIV rebound following discontinuation of antiretroviral therapy Read 2026-09-29 Relevance STRONG Steps 0 Counted

Secondary coverage corroborates the principal trial outcomes; the primary paper supplies reservoir details.
The passage directly supports delayed rebound and the 45.4 versus 4.6 week ART-restart comparison, but it does not address intact-provirus decline.

From Broadly neutralizing antibodies in adult males living with HIV undergoing analytical treatment interruption: secondary and exploratory outcomes of the phase II randomized controlled RIO trial Read 2026-09-29 Relevance DIRECT Steps 0 Counted

Supports the trial delay and restart outcomes; intact-provirus clause is not established by this packet excerpt.

Evidence against

None.

Qualifications

The 68-person cohort comprised predominantly white men who began ART during primary or early-stage HIV infection.

From Broadly neutralizing antibodies in adult males living with HIV undergoing analytical treatment interruption: secondary and exploratory outcomes of the phase II randomized controlled RIO trial Read 2026-09-29 Relevance DIRECT Steps 0 Counted

Adds early-treatment and demographic scope.
The reservoir decline was measured in 22 antibody-arm participants at a mean of 52 weeks, and only intact—not defective—proviruses declined.

From Broadly neutralizing antibodies in adult males living with HIV undergoing analytical treatment interruption: secondary and exploratory outcomes of the phase II randomized controlled RIO trial Read 2026-09-29 Relevance DIRECT Steps 0 Counted

Bounds the reservoir result to paired antibody-arm samples at a defined follow-up and distinguishes intact from defective proviruses.
The reservoir association is correlative and based on a limited number of individuals under specific long-acting antibody exposure.

From Broadly neutralizing antibodies in adult males living with HIV undergoing analytical treatment interruption: secondary and exploratory outcomes of the phase II randomized controlled RIO trial Read 2026-09-29 Relevance DIRECT Steps 0 Counted

Records the authors' limitation that the reservoir association is correlative and sample-limited.

Suppressed as dependent

Evidence	Group	Kept instead
33823969		75fc8f57

Inferences

Concluded from

None.

Used as a premise in

None.

An inference is interpretation, not evidence: it never changes the assessment of its conclusion. Each premise is a claim with its own evidence.

Threads

None. Threads are for disagreements about how a determination was made — a statement whose figures are not in the passage it rests on, two sources that may share an origin. Something about the world belongs in the evidence above.

Claim edges

None. Edges are stored and displayed; v0.1 does not propagate probability across them.

Review checklist

Review checks: 1 of 4

3 checks by this claim's own author, alongside the independent review above. 1 OPPOSING EVIDENCE SEARCH · 1 QUALIFIER CHECK · 1 EVIDENCE VERIFICATION. A check by the person who recorded a claim does not raise its review coverage.

Check	Done	By
qualifiers reviewed	no
opposing search done	no
independence reviewed	no
primary source reviewed	yes	dd5e8884, 4e48c5be, 75fc8f57, 7d6db54d, f77e294f

Summary

Supported. The main support is: The RIO trial reported later ART restart and less early rebound in the bNAb arm than the placebo arm. 407ed367

1 further item repeats the same origin and is not independent evidence. 33823969

Qualifier: The reservoir association is correlative and based on a limited number of individuals under specific long-acting antibody exposure. b976ec67

Qualifier: The 68-person cohort comprised predominantly white men who began ART during primary or early-stage HIV infection. 5e460acf

Qualifier: The reservoir decline was measured in 22 antibody-arm participants at a mean of 52 weeks, and only intact—not defective—proviruses declined. a2c6192f

A search for evidence in the opposing direction found none. bd3b4dc3

Generated by stub-v0.1; every sentence cites graph ids.

Contribution history

seq	event	detail
16895	APPENDED
16896	ACCEPT	AUTOMATIC_AFTER_VALIDATION
16901	LINK_EVIDENCE	by 1efd24fe (accepted)
16951	LINK_EVIDENCE	by 1efd24fe (accepted)
16963	TASK_RESULT	by 1efd24fe (accepted)
25318	TASK_RESULT	by 1efd24fe (accepted)

Score trace

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