Claim

In the facial atlas, gene-expression associations with facial traits were strongest in early mesenchymal progenitor cells and became more region restricted over development.

Type OBSERVATIONAL · truth-evaluable: yes · status at snapshot: ACTIVE · created seq 24205 · qualifiers {"population":"Embryonic facial mesenchymal cells"}

a conjunction joins clauses that may be separately evaluable

Referenced 169 times: checked 1, looked up by assistants 0, viewed 125, shared 43. A count of attention, not evidence.

Topics

Medicine · 1efd24fe Biology · 1efd24fe

Assessment

Supported

Score: 0.8581 under ledger-default@0.3.0 at snapshot 27745

2 of 4 review checks done · 1 counted · 1 by the author only

1 independent evidence lineage · review checks 1 of 4 · stability MEDIUM

Main unresolved issue: 3 counted evidence items have no independence review; repeats of one origin may be counted as several coverage:5905a458-d35e-8355-8d54-e9bd5e199669

Not yet independently audited.Evidence reviewed so far supports this claim, but only 1 of 4 review checks has been done.A quoted passage from nature.com was not found on the page when Galedra fetched it.

Why?

Strongest counted support: The abstract places the strongest facial-trait gene-expression associations in early mesenchymal progenitors before regional restriction. weight 1.800000 evidence

Suppressed as dependent: The quoted passage directly reports strongest facial-trait gene-expression associations in early mesenchymal progenitors becoming gradually more region restricted.

Review gaps: qualifiers reviewed, opposing search done, independence reviewed

What would most change this: One independent, direct measurement that contradicts this claim would move it from Supported to Unresolved.

Hide calculation

0.8581 under ledger-default@0.3.0 at snapshot 27745 · state Supported · Review checks: 1 of 4 · stability MEDIUM · 3 sources, 1 independent lineage

Model ledger-default@0.3.0 (the default model, not the answer) · snapshot 27745 · trace sha256:ec65fabb933690421a329e128c747d4f024df7dfe046dc0359ef8d6cdcc3b82d

Last changed at entry seq 25734; nothing logged since has borne on this claim.

How the number was reached

Each counted link is weighed by multiplying the factors the model declares; a factor it does not declare is not shown. Every factor name below links to what that number means.

Link	Working	Weight	Counted as
8b0a626e support	relevance DIRECT 2.0 × observation DIRECT_TEXT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.800000	1.800000
5d10a06b qualify	relevance DIRECT 2.0 × observation DATASET_RESULT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.800000	0.000000 (non directional)
a6a81b27 support	relevance DIRECT 2.0 × observation DIRECT_TEXT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.800000	0.000000 (dependent strongest only, kept 8b0a626e)

prior 0.50 → log-odds 0.000000 + 1.800000 (the counted weights) = 1.800000 → probability 0.8581

Under neighbouring settings of the same model: 0.7790 to 0.9121, a spread of 0.1331.

Half-even rounding, six places for weights and four for the probability. The same inputs under the same model reproduce this exactly; that is what the trace hash above is for. How a score is worked out explains every factor, why it is there, and what the model sets it to.

Your view

Registered views

Nobody has registered a view yet.

Registered views are personal belief, not evidence: they never change Galedra's assessment. Affiliations are self-declared and shown only for groups of 5 or more.

Checked as part of

Statements this claim was broken out of. The claim is scored on its own; a statement's reading only counts its claims.

“A multimodal embryonic facial atlas links cell states, regulatory elements, and peripheral-nerve signaling to human facial variation and craniofacial...” · 3 claims · 29 September 2026

Evidence for

The abstract places the strongest facial-trait gene-expression associations in early mesenchymal progenitors before regional restriction.

From Atlas of cell types and regulatory elements underlying human facial diversity Read 2026-09-29 Relevance DIRECT Steps 0 Counted
The quoted passage directly reports strongest facial-trait gene-expression associations in early mesenchymal progenitors becoming gradually more region restricted.

From Atlas of cell types and regulatory elements underlying human facial diversity Read 2026-09-29 Relevance DIRECT Steps 0 Counted

The excerpt directly matches both developmental parts of the claim.

Evidence against

None.

Qualifications

The result is restricted to embryonic weeks 6–11 and 56 atlas-defined cell states; trait links combine association/inference with mouse validation rather than universal human causal tracing.

From Atlas of cell types and regulatory elements underlying human facial diversity Read 2026-09-29 Relevance DIRECT Steps 0 Counted

Adds developmental range, cell-state scope, assay/inference boundary, and human-versus-mouse translation limitation.

Suppressed as dependent

Evidence	Group	Kept instead
de628800		8b0a626e

Inferences

Concluded from

None.

Used as a premise in

None.

An inference is interpretation, not evidence: it never changes the assessment of its conclusion. Each premise is a claim with its own evidence.

Threads

None. Threads are for disagreements about how a determination was made — a statement whose figures are not in the passage it rests on, two sources that may share an origin. Something about the world belongs in the evidence above.

Claim edges

None. Edges are stored and displayed; v0.1 does not propagate probability across them.

Review checklist

Review checks: 1 of 4

2 checks by this claim's own author, alongside the independent review above. 1 QUALIFIER CHECK · 1 EVIDENCE VERIFICATION. A check by the person who recorded a claim does not raise its review coverage.

Check	Done	By
qualifiers reviewed	no
opposing search done	no
independence reviewed	no
primary source reviewed	yes	8b0a626e, 5d10a06b, a6a81b27

Summary

Supported. The main support is: The abstract places the strongest facial-trait gene-expression associations in early mesenchymal progenitors before regional restriction. 09cbbb81

1 further item repeats the same origin and is not independent evidence. de628800

Qualifier: The result is restricted to embryonic weeks 6–11 and 56 atlas-defined cell states; trait links combine association/inference with mouse validation rather than universal human causal tracing. 98ddae53

Review checks: 1 of 4. coverage:5905a458-d35e-8355-8d54-e9bd5e199669

Generated by stub-v0.1; every sentence cites graph ids.

Contribution history

seq	event	detail
24205	APPENDED
24206	ACCEPT	AUTOMATIC_AFTER_VALIDATION
24221	LINK_EVIDENCE	by 1efd24fe (accepted)
24657	TASK_RESULT	by 1efd24fe (accepted)
25733	TASK_RESULT	by 1efd24fe (accepted)

Score trace

{
  "claim": "5905a458-d35e-8355-8d54-e9bd5e199669",
  "links": [
    {
      "link": "520c6541-6807-8d64-b93a-11f58b0a626e",
      "group": null,
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "d1058a9f-f182-8628-8f23-461309cbbb81",
      "direction": "SUPPORT",
      "magnitude": "1.800000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "DIRECT_TEXT",
      "source_type": "PRIMARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "1.800000",
      "interpretive_steps": 0
    },
    {
      "link": "55ab4324-4a42-8eba-ba10-b5365d10a06b",
      "group": null,
      "reason": "non_directional",
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "293c49b0-3954-8daf-b5d5-503b98ddae53",
      "direction": "QUALIFY",
      "magnitude": "1.800000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "DATASET_RESULT",
      "source_type": "PRIMARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "0.000000",
      "interpretive_steps": 0
    },
    {
      "kept": "520c6541-6807-8d64-b93a-11f58b0a626e",
      "link": "d31ea9e9-8f34-8e64-8a8f-7cdea6a81b27",
      "group": null,
      "reason": "dependent_strongest_only",
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "3e19327b-06dd-815a-8b21-45dbde628800",
      "direction": "SUPPORT",
      "magnitude": "1.800000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "DIRECT_TEXT",
      "source_type": "PRIMARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "0.000000",
      "interpretive_steps": 0
    }
  ],
  "model": "ledger-default@0.3.0",
  "prior": "0.50",
  "variants": {
    "spread": "0.1331",
    "permissive": "0.9121",
    "conservative": "0.7790"
  },
  "code_hash": "sha256:c61a6fdf35a754a0d7e958df149036a083c0eaeb7d2d2e52704ec32b0c36def7",
  "contested": false,
  "stability": "MEDIUM",
  "claim_type": "OBSERVATIONAL",
  "config_hash": "sha256:86768038080b8ab5233f1e4b7aba10af05b5bb44caa432095150b90e81209809",
  "probability": "0.8581",
  "provisional": true,
  "evidence_sum": "1.800000",
  "snapshot_seq": 25734,
  "prior_log_odds": "0.000000",
  "support_groups": 1,
  "model_dependent": false,
  "review_coverage": "0.25",
  "truth_evaluable": true,
  "assessment_state": "SUPPORTED",
  "review_checklist": {
    "qualifiers_reviewed": {
      "by": [],
      "ok": false
    },
    "opposing_search_done": {
      "by": [],
      "ok": false
    },
    "independence_reviewed": {
      "by": [],
      "ok": false
    },
    "primary_source_reviewed": {
      "by": [
        "520c6541-6807-8d64-b93a-11f58b0a626e",
        "55ab4324-4a42-8eba-ba10-b5365d10a06b",
        "d31ea9e9-8f34-8e64-8a8f-7cdea6a81b27"
      ],
      "ok": true
    }
  },
  "contradict_groups": 0,
  "rounding_boundary": false,
  "posterior_log_odds": "1.800000",
  "not_applicable_reason": null,
  "independence_unreviewed": 3
}