Claim

In a double-blind pilot randomized trial of opioid-exposed newborns managed with Eat, Sleep, Console, high-calorie versus standard feeds showed no significant differences in weight loss, length of stay, or stool frequency, while breastfeeding at discharge was more frequent with high-calorie feeds.

Type QUANTITATIVE · truth-evaluable: yes · status at snapshot: ACTIVE · created seq 19074

41 words; atomic claims are usually under 25a conjunction joins clauses that may be separately evaluablea comma-separated series may list several propositions

Referenced 159 times: checked 2, looked up by assistants 1, viewed 119, shared 37. A count of attention, not evidence.

Topics

Medicine · 1efd24fe Nutrition · 1efd24fe

Assessment

Supported

Score: 0.9121 under ledger-default@0.3.0 at snapshot 27745

2 of 4 review checks done · 1 counted · 1 by the author only

2 independent evidence lineages · review checks 1 of 4 · stability MEDIUM

Main unresolved issue: 6 counted evidence items have no independence review; repeats of one origin may be counted as several coverage:5bb20686-61fc-8927-9efd-2fcb3a4047e6

Not yet independently audited.Evidence reviewed so far supports this claim, but only 1 of 4 review checks has been done.A quoted passage from nature.com and pmc.ncbi.nlm.nih.gov was not found on the page when Galedra fetched it.

Related: NARROWS incoming: Supported

Why?

Strongest counted support: The pilot found no significant differences in weight loss, length of stay, or stool frequency, while breastfeeding at discharge was more frequent with high-calorie feeds. weight 1.800000 evidence

Suppressed as dependent: The passage directly reports the randomized sample, null weight-loss, length-of-stay, and stool outcomes, and breastfeeding difference.

Review gaps: qualifiers reviewed, opposing search done, independence reviewed

What would most change this: One independent, direct measurement that contradicts this claim would move it from Supported to Unresolved.

Hide calculation

0.9121 under ledger-default@0.3.0 at snapshot 27745 · state Supported · Review checks: 1 of 4 · stability MEDIUM · 6 sources, 2 independent lineages

Model ledger-default@0.3.0 (the default model, not the answer) · snapshot 27745 · trace sha256:34091ab44f1a67d836a4e68772f5e4df5dfea99830663dd2285a4970f54d93b1

Last changed at entry seq 25470; nothing logged since has borne on this claim.

How the number was reached

Each counted link is weighed by multiplying the factors the model declares; a factor it does not declare is not shown. Every factor name below links to what that number means.

Link	Working	Weight	Counted as
75672a05 support	relevance DIRECT 2.0 × observation DATASET_RESULT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.800000	1.800000
577631fa qualify	relevance DIRECT 2.0 × observation DIRECT_TEXT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.800000	0.000000 (non directional)
0c878c85 qualify	relevance DIRECT 2.0 × observation DATASET_RESULT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.800000	0.000000 (non directional)
a76e7879 qualify	relevance DIRECT 2.0 × observation DIRECT_TEXT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.800000	0.000000 (non directional)
4f022064 support	relevance DIRECT 2.0 × observation DIRECT_TEXT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.800000	0.000000 (dependent strongest only, kept 75672a05)
263f5893 support	relevance MODERATE 0.6 × observation DIRECT_TEXT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	0.540000	0.540000

prior 0.50 → log-odds 0.000000 + 2.340000 (the counted weights) = 2.340000 → probability 0.9121

Under neighbouring settings of the same model: 0.8373 to 0.9544, a spread of 0.1171.

Half-even rounding, six places for weights and four for the probability. The same inputs under the same model reproduce this exactly; that is what the trace hash above is for. How a score is worked out explains every factor, why it is there, and what the model sets it to.

Your view

Registered views

Nobody has registered a view yet.

Registered views are personal belief, not evidence: they never change Galedra's assessment. Affiliations are self-declared and shown only for groups of 5 or more.

Checked as part of

Statements this claim was broken out of. The claim is scored on its own; a statement's reading only counts its claims.

“In a double-blind pilot randomized trial of opioid-exposed newborns managed with Eat, Sleep, Console, high-calorie versus standard feeds showed no...” · 1 claim · 29 September 2026
“In a double-blind pilot randomized trial of opioid-exposed newborns managed with Eat, Sleep, Console, high-calorie versus standard feeds showed no...” · 1 claim · 29 September 2026

Evidence for

The pilot found no significant differences in weight loss, length of stay, or stool frequency, while breastfeeding at discharge was more frequent with high-calorie feeds.

From Randomized pilot study comparing standard vs high-calorie feeding in infants with Neonatal Opioid Withdrawal Syndrome Read 2026-09-29 Relevance DIRECT Steps 0 Counted
The passage directly reports the randomized sample, null weight-loss, length-of-stay, and stool outcomes, and breastfeeding difference.

From Randomized pilot study comparing standard vs high-calorie feeding in infants with Neonatal Opioid Withdrawal Syndrome Read 2026-09-29 Relevance DIRECT Steps 0 Counted
An independent earlier double-blind randomized feasibility study in methadone-exposed infants likewise found no significant main outcome differences between standard- and high-calorie formula, providing contextual support for the newer pilot's null findings.

From Randomized Clinical Trial of Standard- Versus High-Calorie Formula for Methadone-Exposed Infants: A Feasibility Study Read 2026-09-29 Relevance MODERATE Steps 0 Counted

This is a distinct earlier trial and supports the direction of the newer claim, but it is not a replication of the 2026 ESC-managed cohort.

Evidence against

None.

Qualifications

The double-blind pilot was conducted in Connecticut among methadone- or buprenorphine-exposed infants younger than 48 hours.

From Randomized pilot study comparing standard vs high-calorie feeding in infants with Neonatal Opioid Withdrawal Syndrome Read 2026-09-29 Relevance DIRECT Steps 0 Counted

Adds jurisdiction, exposure definition, and age criterion.
Only 35 of 65 eligible infants were randomized, with 84% adherence and substantial post-discharge attrition.

From Randomized pilot study comparing standard vs high-calorie feeding in infants with Neonatal Opioid Withdrawal Syndrome Read 2026-09-29 Relevance DIRECT Steps 0 Counted

Adds dates, randomized denominator, adherence, and retention limitations.
Enrollment, adherence, and retention were primary outcomes; breastfeeding and stooling were exploratory.

From Randomized pilot study comparing standard vs high-calorie feeding in infants with Neonatal Opioid Withdrawal Syndrome Read 2026-09-29 Relevance DIRECT Steps 0 Counted

Clarifies the pilot's primary and exploratory outcome structure.

Suppressed as dependent

Evidence	Group	Kept instead
ef01ea5a		75672a05

Inferences

Concluded from

None.

Used as a premise in

None.

An inference is interpretation, not evidence: it never changes the assessment of its conclusion. Each premise is a claim with its own evidence.

Threads

None. Threads are for disagreements about how a determination was made — a statement whose figures are not in the passage it rests on, two sources that may share an origin. Something about the world belongs in the evidence above.

Claim edges

From	Relationship	To
36747769	NARROWS	3a4047e6

Review checklist

Review checks: 1 of 4

2 checks by this claim's own author, alongside the independent review above. 1 QUALIFIER CHECK · 1 EVIDENCE VERIFICATION. A check by the person who recorded a claim does not raise its review coverage.

Check	Done	By
qualifiers reviewed	no
opposing search done	no
independence reviewed	no
primary source reviewed	yes	75672a05, 577631fa, 0c878c85, a76e7879, 4f022064, 263f5893

Summary

Supported. The main support is: The pilot found no significant differences in weight loss, length of stay, or stool frequency, while breastfeeding at discharge was more frequent with high-calorie feeds. 411baa97

1 further item repeats the same origin and is not independent evidence. ef01ea5a

Qualifier: The double-blind pilot was conducted in Connecticut among methadone- or buprenorphine-exposed infants younger than 48 hours. 82fd5ef2

Qualifier: Only 35 of 65 eligible infants were randomized, with 84% adherence and substantial post-discharge attrition. 2dc0fb85

Qualifier: Enrollment, adherence, and retention were primary outcomes; breastfeeding and stooling were exploratory. a07f0e4b

A narrower version of this claim is supported. 36747769

Generated by stub-v0.1; every sentence cites graph ids.

Contribution history

seq	event	detail
19074	APPENDED
19075	ACCEPT	AUTOMATIC_AFTER_VALIDATION
19080	LINK_EVIDENCE	by 1efd24fe (accepted)
19099	TASK_RESULT	by 1efd24fe (accepted)
19173	LINK_EVIDENCE	by 1efd24fe (accepted)
25469	TASK_RESULT	by 1efd24fe (accepted)

Score trace

{
  "claim": "5bb20686-61fc-8927-9efd-2fcb3a4047e6",
  "links": [
    {
      "link": "1155dc3c-3151-8d0c-b9c1-039575672a05",
      "group": null,
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "32f7333e-3b9d-89da-b496-8858411baa97",
      "direction": "SUPPORT",
      "magnitude": "1.800000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "DATASET_RESULT",
      "source_type": "PRIMARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "1.800000",
      "interpretive_steps": 0
    },
    {
      "link": "2dc715b7-d68b-83f8-990a-9656577631fa",
      "group": null,
      "reason": "non_directional",
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "4254c57d-9b45-8a83-a946-f65182fd5ef2",
      "direction": "QUALIFY",
      "magnitude": "1.800000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "DIRECT_TEXT",
      "source_type": "PRIMARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "0.000000",
      "interpretive_steps": 0
    },
    {
      "link": "8ee1add7-63bc-8da1-b5b8-33320c878c85",
      "group": null,
      "reason": "non_directional",
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "20814b5d-1923-8470-92c7-15d82dc0fb85",
      "direction": "QUALIFY",
      "magnitude": "1.800000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "DATASET_RESULT",
      "source_type": "PRIMARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "0.000000",
      "interpretive_steps": 0
    },
    {
      "link": "9c22bd97-ec7a-8439-be89-b14da76e7879",
      "group": null,
      "reason": "non_directional",
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "0f99a19b-28a8-81ab-a011-a6b3a07f0e4b",
      "direction": "QUALIFY",
      "magnitude": "1.800000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "DIRECT_TEXT",
      "source_type": "PRIMARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "0.000000",
      "interpretive_steps": 0
    },
    {
      "kept": "1155dc3c-3151-8d0c-b9c1-039575672a05",
      "link": "ac7f2d4d-05a6-8e0e-8acc-24184f022064",
      "group": null,
      "reason": "dependent_strongest_only",
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "d3219ee6-12eb-89a4-a21e-ccf7ef01ea5a",
      "direction": "SUPPORT",
      "magnitude": "1.800000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "DIRECT_TEXT",
      "source_type": "PRIMARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "0.000000",
      "interpretive_steps": 0
    },
    {
      "link": "e1461068-7697-830b-94bb-349a263f5893",
      "group": null,
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "47760fcb-8cbe-8392-ba34-b9ec4d30aa78",
      "direction": "SUPPORT",
      "magnitude": "0.540000",
      "relevance": "MODERATE",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "DIRECT_TEXT",
      "source_type": "PRIMARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "0.540000",
      "interpretive_steps": 0
    }
  ],
  "model": "ledger-default@0.3.0",
  "prior": "0.50",
  "variants": {
    "spread": "0.1171",
    "permissive": "0.9544",
    "conservative": "0.8373"
  },
  "code_hash": "sha256:c61a6fdf35a754a0d7e958df149036a083c0eaeb7d2d2e52704ec32b0c36def7",
  "contested": false,
  "stability": "MEDIUM",
  "claim_type": "QUANTITATIVE",
  "config_hash": "sha256:86768038080b8ab5233f1e4b7aba10af05b5bb44caa432095150b90e81209809",
  "probability": "0.9121",
  "provisional": true,
  "evidence_sum": "2.340000",
  "snapshot_seq": 25470,
  "prior_log_odds": "0.000000",
  "support_groups": 2,
  "model_dependent": false,
  "review_coverage": "0.25",
  "truth_evaluable": true,
  "assessment_state": "SUPPORTED",
  "review_checklist": {
    "qualifiers_reviewed": {
      "by": [],
      "ok": false
    },
    "opposing_search_done": {
      "by": [],
      "ok": false
    },
    "independence_reviewed": {
      "by": [],
      "ok": false
    },
    "primary_source_reviewed": {
      "by": [
        "1155dc3c-3151-8d0c-b9c1-039575672a05",
        "2dc715b7-d68b-83f8-990a-9656577631fa",
        "8ee1add7-63bc-8da1-b5b8-33320c878c85",
        "9c22bd97-ec7a-8439-be89-b14da76e7879",
        "ac7f2d4d-05a6-8e0e-8acc-24184f022064",
        "e1461068-7697-830b-94bb-349a263f5893"
      ],
      "ok": true
    }
  },
  "contradict_groups": 0,
  "rounding_boundary": false,
  "posterior_log_odds": "2.340000",
  "not_applicable_reason": null,
  "independence_unreviewed": 6
}